Publication Date:
2000-01-15
Description:
The memory consolidation hypothesis proposed 100 years ago by Muller and Pilzecker continues to guide memory research. The hypothesis that new memories consolidate slowly over time has stimulated studies revealing the hormonal and neural influences regulating memory consolidation, as well as molecular and cellular mechanisms. This review examines the progress made over the century in understanding the time-dependent processes that create our lasting memories.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McGaugh, J L -- MH12526/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2000 Jan 14;287(5451):248-51.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉the Center for the Neurobiology of Learning and Memory and the Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA 92697, USA. jlmcgaug@uci.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10634773" target="_blank"〉PubMed〈/a〉
Keywords:
Amnesia, Retrograde/physiopathology
;
Amygdala/*physiology
;
Animals
;
Brain/*physiology
;
Emotions
;
Hippocampus/physiology
;
Humans
;
Long-Term Potentiation
;
Memory/*physiology
;
Memory, Short-Term/physiology
;
Protein Kinases/metabolism
;
Receptors, Adrenergic, beta/physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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