Publication Date:
2000-01-22
Description:
Stunned myocardium is a syndrome of reversible contractile failure that frequently complicates coronary artery disease. Cardiac excitation is uncoupled from contraction at the level of the myofilaments. Selective proteolysis of the thin filament protein troponin I has been correlated with stunned myocardium. Here, transgenic mice expressing the major degradation product of troponin I (TnI1-193) in the heart were found to develop ventricular dilatation, diminished contractility, and reduced myofilament calcium responsiveness, recapitulating the phenotype of stunned myocardium. Proteolysis of troponin I also occurs in ischemic human cardiac muscle. Thus, troponin I proteolysis underlies the pathogenesis of a common acquired form of heart failure.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Murphy, A M -- Kogler, H -- Georgakopoulos, D -- McDonough, J L -- Kass, D A -- Van Eyk, J E -- Marban, E -- HL 44065/HL/NHLBI NIH HHS/ -- HL 63038/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 2000 Jan 21;287(5452):488-91.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pediatrics, Johns Hopkins University School of Medicine, Ross Building 1144, 720 Rutland Avenue, Baltimore, MD 21205, USA. murphy@jhmi.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10642551" target="_blank"〉PubMed〈/a〉
Keywords:
Actin Cytoskeleton/metabolism
;
Adrenergic beta-Agonists/pharmacology
;
Animals
;
Calcium/metabolism
;
Cardiomegaly/pathology
;
Dilatation, Pathologic
;
*Disease Models, Animal
;
Heart Rate
;
Heart Ventricles/pathology
;
Humans
;
Isoproterenol/pharmacology
;
Mice
;
Mice, Inbred C57BL
;
*Mice, Transgenic
;
Myocardial Contraction
;
Myocardial Stunning/*metabolism/pathology/physiopathology
;
Myocardium/*metabolism/pathology
;
Myofibrils/metabolism
;
Troponin I/genetics/*metabolism
;
Ventricular Function, Left
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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