Publication Date:
1999-01-08
Description:
The charge state of ions produced in electrospray ionization (ESI) was reduced in a controlled manner to yield predominantly singly charged species by exposure of the aerosol to a bipolar ionizing gas. Analysis of the resulting ions on an orthogonal time-of-flight mass spectrometer yielded mass spectra greatly simplified compared with conventional ESI spectra. The decreased spectral complexity afforded by the charge reduction facilitates the analysis of mixtures by ESI mass spectrometry.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Scalf, M -- Westphall, M S -- Krause, J -- Kaufman, S L -- Smith, L M -- 5T32GMO8349/GM/NIGMS NIH HHS/ -- R01HG001808/HG/NHGRI NIH HHS/ -- R01HG00321/HG/NHGRI NIH HHS/ -- New York, N.Y. -- Science. 1999 Jan 8;283(5399):194-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, University of Wisconsin, Madison, WI 53706-1396, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9880246" target="_blank"〉PubMed〈/a〉
Keywords:
Aerosols
;
Cytochrome c Group/analysis
;
Electrochemistry
;
Insulin/analysis
;
*Ions
;
*Mass Spectrometry/instrumentation/methods
;
Oligonucleotides/*analysis
;
Polonium
;
Proteins/*analysis
;
Ubiquitins/analysis
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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