Publication Date:
1999-07-20
Description:
The molecular basis of adaptation is a major focus of evolutionary biology, yet the dynamic process of adaptation has been explored only piecemeal. Experimental evolution of two bacteriophage lines under strong selection led to over a dozen nucleotide changes genomewide in each replicate. At least 96 percent of the amino acid substitutions appeared to be adaptive, and half the changes in one line also occurred in the other. However, the order of these changes differed between replicates, and parallel substitutions did not reflect the changes with the largest beneficial effects or indicate a common trajectory of adaptation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wichman, H A -- Badgett, M R -- Scott, L A -- Boulianne, C M -- Bull, J J -- GM57755/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1999 Jul 16;285(5426):422-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Sciences, University of Idaho, Moscow, ID 83844, USA. hwichman@uidaho.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10411508" target="_blank"〉PubMed〈/a〉
Keywords:
*Adaptation, Physiological
;
Amino Acid Substitution
;
Bacteriophage phi X 174/*genetics/*physiology
;
*Evolution, Molecular
;
*Genome, Viral
;
Genotype
;
Mutation
;
Salmonella typhimurium/*virology
;
Selection, Genetic
;
Sequence Deletion
;
Temperature
;
Viral Plaque Assay
;
Viral Proteins/chemistry/genetics
;
Virus Replication
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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