ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    facet.materialart.
    Unknown
    Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic (2009)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2009-06-12
    Description: In March and early April 2009, a new swine-origin influenza A (H1N1) virus (S-OIV) emerged in Mexico and the United States. During the first few weeks of surveillance, the virus spread worldwide to 30 countries (as of May 11) by human-to-human transmission, causing the World Health Organization to raise its pandemic alert to level 5 of 6. This virus has the potential to develop into the first influenza pandemic of the twenty-first century. Here we use evolutionary analysis to estimate the timescale of the origins and the early development of the S-OIV epidemic. We show that it was derived from several viruses circulating in swine, and that the initial transmission to humans occurred several months before recognition of the outbreak. A phylogenetic estimate of the gaps in genetic surveillance indicates a long period of unsampled ancestry before the S-OIV outbreak, suggesting that the reassortment of swine lineages may have occurred years before emergence in humans, and that the multiple genetic ancestry of S-OIV is not indicative of an artificial origin. Furthermore, the unsampled history of the epidemic means that the nature and location of the genetically closest swine viruses reveal little about the immediate origin of the epidemic, despite the fact that we included a panel of closely related and previously unpublished swine influenza isolates. Our results highlight the need for systematic surveillance of influenza in swine, and provide evidence that the mixing of new genetic elements in swine can result in the emergence of viruses with pandemic potential in humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, Gavin J D -- Vijaykrishna, Dhanasekaran -- Bahl, Justin -- Lycett, Samantha J -- Worobey, Michael -- Pybus, Oliver G -- Ma, Siu Kit -- Cheung, Chung Lam -- Raghwani, Jayna -- Bhatt, Samir -- Peiris, J S Malik -- Guan, Yi -- Rambaut, Andrew -- BB/E009670/1/Biotechnology and Biological Sciences Research Council/United Kingdom -- HHSN266200700005C/PHS HHS/ -- Biotechnology and Biological Sciences Research Council/United Kingdom -- England -- Nature. 2009 Jun 25;459(7250):1122-5. doi: 10.1038/nature08182.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉State Key Laboratory of Emerging Infectious Diseases & Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19516283" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Disease Outbreaks ; *Evolution, Molecular ; Genome, Viral/*genetics ; Humans ; Influenza A Virus, H1N1 Subtype/classification/*genetics ; *Influenza, Human/epidemiology/virology ; Molecular Sequence Data ; Orthomyxoviridae Infections/epidemiology/veterinary/virology ; Phylogeny ; Reassortant Viruses/classification/*genetics ; Swine ; Swine Diseases/*virology ; Time Factors
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 2
    facet.materialart.
    Unknown
    Long-term evolution and transmission dynamics of swine influenza A virus (2011)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2011-05-27
    Description: Swine influenza A viruses (SwIV) cause significant economic losses in animal husbandry as well as instances of human disease and occasionally give rise to human pandemics, including that caused by the H1N1/2009 virus. The lack of systematic and longitudinal influenza surveillance in pigs has hampered attempts to reconstruct the origins of this pandemic. Most existing swine data were derived from opportunistic samples collected from diseased pigs in disparate geographical regions, not from prospective studies in defined locations, hence the evolutionary and transmission dynamics of SwIV are poorly understood. Here we quantify the epidemiological, genetic and antigenic dynamics of SwIV in Hong Kong using a data set of more than 650 SwIV isolates and more than 800 swine sera from 12 years of systematic surveillance in this region, supplemented with data stretching back 34 years. Intercontinental virus movement has led to reassortment and lineage replacement, creating an antigenically and genetically diverse virus population whose dynamics are quantitatively different from those previously observed for human influenza viruses. Our findings indicate that increased antigenic drift is associated with reassortment events and offer insights into the emergence of influenza viruses with epidemic potential in swine and humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vijaykrishna, Dhanasekaran -- Smith, Gavin J D -- Pybus, Oliver G -- Zhu, Huachen -- Bhatt, Samir -- Poon, Leo L M -- Riley, Steven -- Bahl, Justin -- Ma, Siu K -- Cheung, Chung L -- Perera, Ranawaka A P M -- Chen, Honglin -- Shortridge, Kennedy F -- Webby, Richard J -- Webster, Robert G -- Guan, Yi -- Peiris, J S Malik -- HHSN26600700005C/PHS HHS/ -- MC_G0902096/Medical Research Council/United Kingdom -- England -- Nature. 2011 May 26;473(7348):519-22. doi: 10.1038/nature10004.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉State Key Laboratory of Emerging Infectious Diseases & Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, China.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21614079" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Birds/virology ; *Evolution, Molecular ; Female ; Hong Kong/epidemiology ; Humans ; Influenza A Virus, H1N1 Subtype/classification/genetics/isolation & ; purification/*physiology ; Influenza in Birds/transmission/virology ; Influenza, Human/epidemiology/transmission/virology ; Male ; Molecular Epidemiology ; Molecular Sequence Data ; Orthomyxoviridae Infections/epidemiology/transmission/*veterinary/virology ; Phylogeny ; Population Surveillance ; Reassortant Viruses/genetics/immunology/isolation & purification/physiology ; Swine/blood/*virology ; Swine Diseases/blood/epidemiology/*transmission/*virology ; Zoonoses/epidemiology/transmission/*virology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 3
    facet.materialart.
    Unknown
    Dengue subgenomic RNA binds TRIM25 to inhibit interferon expression for epidemiological fitness (2015)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2015-07-04
    Description: The global spread of dengue virus (DENV) infections has increased viral genetic diversity, some of which appears associated with greater epidemic potential. The mechanisms governing viral fitness in epidemiological settings, however, remain poorly defined. We identified a determinant of fitness in a foreign dominant (PR-2B) DENV serotype 2 (DENV-2) clade, which emerged during the 1994 epidemic in Puerto Rico and replaced an endemic (PR-1) DENV-2 clade. The PR-2B DENV-2 produced increased levels of subgenomic flavivirus RNA (sfRNA) relative to genomic RNA during replication. PR-2B sfRNA showed sequence-dependent binding to and prevention of tripartite motif 25 (TRIM25) deubiquitylation, which is critical for sustained and amplified retinoic acid-inducible gene 1 (RIG-I)-induced type I interferon expression. Our findings demonstrate a distinctive viral RNA-host protein interaction to evade the innate immune response for increased epidemiological fitness.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Manokaran, Gayathri -- Finol, Esteban -- Wang, Chunling -- Gunaratne, Jayantha -- Bahl, Justin -- Ong, Eugenia Z -- Tan, Hwee Cheng -- Sessions, October M -- Ward, Alex M -- Gubler, Duane J -- Harris, Eva -- Garcia-Blanco, Mariano A -- Ooi, Eng Eong -- R01 AI089526/AI/NIAID NIH HHS/ -- R01 GM087405/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2015 Oct 9;350(6257):217-21. doi: 10.1126/science.aab3369. Epub 2015 Jul 2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Program in Emerging Infectious Diseases, Duke-National University of Singapore Graduate Medical School, Singapore. Defence Medical and Environmental Research Institute, DSO National Laboratories, Singapore. Yong Loo Lin School of Medicine, National University of Singapore, Singapore. ; Program in Emerging Infectious Diseases, Duke-National University of Singapore Graduate Medical School, Singapore. Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Swiss Tropical and Public Health Institute, Universitat Basel, Switzerland. ; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, CA, USA. ; Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Institute of Molecular and Cell Biology, Singapore. ; Center for Infectious Diseases, The University of Texas School of Public Health, Houston, TX, USA. ; Program in Emerging Infectious Diseases, Duke-National University of Singapore Graduate Medical School, Singapore. ; Program in Emerging Infectious Diseases, Duke-National University of Singapore Graduate Medical School, Singapore. Department of Biochemistry and Molecular Biology, The University of Texas Medical Branch, Galveston, TX, USA. Department of Molecular Genetics and Microbiology and Center for RNA Biology, Duke University, Durham, NC, USA. ; Program in Emerging Infectious Diseases, Duke-National University of Singapore Graduate Medical School, Singapore. Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Saw Swee Hock School of Public Health, National University of Singapore, Singapore. Singapore-Massachusetts Institute of Technology Alliance in Research and Technology Infectious Disease Interdisciplinary Research Group, Singapore. engeong.ooi@duke-nus.edu.sg.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26138103" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biodiversity ; Cercopithecus aethiops ; DEAD-box RNA Helicases/metabolism ; Dengue/epidemiology/*immunology/*virology ; Dengue Virus/genetics/*physiology ; Humans ; *Immunity, Innate ; Interferon Type I/antagonists & inhibitors/genetics/*immunology ; Puerto Rico/epidemiology ; RNA, Viral/genetics/*metabolism ; Transcription Factors/*metabolism ; Ubiquitin-Protein Ligases/*metabolism ; Ubiquitination ; Vero Cells ; *Virus Replication
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 4
    Electronic Resource
    Electronic Resource
    The Pharmacology of Carnitine (1987)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Pharmacology 27 (1987), S. 257-277 
    Details
    ISSN: 0362-1642
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.pa.27.040187.001353
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Phosphatidylcholine molecular species formed by lysophosphatidylcholine acyltransferase from soya bean microsomes
    Amsterdam : Elsevier
    Phytochemistry 35 (1994), S. 1171-1175 
    Details
    ISSN: 0031-9422
    Keywords: Glycine max ; Leguminosae ; lysophosphatidylcholine acyltransferase ; microsomes ; phosphatidylcholine molecular species. ; soya bean
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0031-9422(00)94816-7
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Phosphatidylcholine molecular species formed by lysophosphatidylcholine acyltransferase from soya bean microsomes
    Amsterdam : Elsevier
    Phytochemistry 35 (1994), S. 1171-1175 
    Details
    ISSN: 0031-9422
    Keywords: Glycine max ; Leguminosae ; lysophosphatidylcholine acyltransferase ; microsomes ; phosphatidylcholine molecular species. ; soya bean
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0031-9422(00)94816-7
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Technische Mitteilungen (1935)
    Springer
    Naturwissenschaften 23 (1935), S. 562-566 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01495556
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Chlorophyll mutations in mungbean (Vigna radiata (L.) Wilczek) (1982)
    Springer
    Theoretical and applied genetics 63 (1982), S. 23-26 
    Details
    ISSN: 1432-2242
    Keywords: Vigna radiata ; Chlorophyll mutations ; EMS ; Gamma radiation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Chlorophyll mutations in two varieties (‘ML-5’ and ‘K-851’) of mungbean (Vigna radiata (L.) Wilczek) were studied severally and in combination following treatment with gamma rays and EMS. Frequencies, spectra and inheritance patterns are reported and discussed. Genotypic differences were observed with regard to frequency and spectrum. Combined treatments produced higher mutation frequencies than individual treatments. Albina and xantha appeared more frequently, relative to other chlorophyll mutations. Inheritance of albina, chlorina, xantha and virescens types in different generations revealed that each of them was monogenically controlled and was recessive in nature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00303485
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    facet.materialart.
    Unknown
    Thyroid hormone regulates expression of a transfected human alpha-myosin heavy-chain fusion gene in fetal rat heart cells. (1990)
    National Academy of Sciences
    Details
    Publication Date: 1990-01-01
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 10
    facet.materialart.
    Unknown
    Thyroid hormone regulates expression of a transfected alpha-myosin heavy-chain fusion gene in fetal heart cells. (1987)
    National Academy of Sciences
    Details
    Publication Date: 1987-05-01
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...