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  • 1
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    Potent analgesic effects of GDNF in neuropathic pain states (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-10-06
    Description: Neuropathic pain arises as a debilitating consequence of nerve injury. The etiology of such pain is poorly understood, and existing treatment is largely ineffective. We demonstrate here that glial cell line-derived neurotrophic factor (GDNF) both prevented and reversed sensory abnormalities that developed in neuropathic pain models, without affecting pain-related behavior in normal animals. GDNF reduces ectopic discharges within sensory neurons after nerve injury. This may arise as a consequence of the reversal by GDNF of the injury-induced plasticity of several sodium channel subunits. Together these findings provide a rational basis for the use of GDNF as a therapeutic treatment for neuropathic pain states.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Boucher, T J -- Okuse, K -- Bennett, D L -- Munson, J B -- Wood, J N -- McMahon, S B -- New York, N.Y. -- Science. 2000 Oct 6;290(5489):124-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre for Neuroscience Research, King's College London, London SE1 7EH, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11021795" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials/drug effects ; Analgesics, Non-Narcotic/pharmacology/*therapeutic use ; Animals ; Ganglia, Spinal/physiopathology ; Glial Cell Line-Derived Neurotrophic Factor ; Hot Temperature ; Hyperalgesia/*drug therapy ; Ligation ; Nerve Fibers/drug effects/physiology ; Nerve Fibers, Myelinated/drug effects/physiology ; *Nerve Growth Factors ; Nerve Tissue Proteins/pharmacology/*therapeutic use ; Neural Conduction/drug effects ; Neurons, Afferent/drug effects/physiology ; Pain/*drug therapy ; Pain Threshold/drug effects ; Peripheral Nervous System Diseases/*physiopathology ; Rats ; Reverse Transcriptase Polymerase Chain Reaction ; Sciatic Nerve ; Sodium Channels/genetics/metabolism ; Spinal Nerves ; Touch
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    PAPER CURRENT
  • 2
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    Preliminary Solar Sail Design and Fabrication Assessment: Spinning Sail Blade, Square Sail Sheet (1977)
    In:  CASI
    Details
    Publication Date: 2019-06-27
    Description: The designs and fabrication methods, equipment, facilities, economics, and schedules, for the square sail sheet alternate are evaluated. The baseline for the spinning sail blade design and related fabrication issues are assessed.
    Keywords: LAUNCH VEHICLES AND SPACE VEHICLES
    Type: NASA-CR-155591
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 3
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    The effect of configuration on strength, durability, and handle of Kevlar fabric-based materials (1977)
    In:  CASI
    Details
    Publication Date: 2019-06-27
    Description: Five Kevlar based laminates and three Kevlar based coated materials were designed, hand made, and tested against comparative conventional Dacron based materials for strength, peel, tear, puncture, creases, and handle. Emphasis was placed on evaluating geometric orientation of constituents, use of elastomeric film in place of high modulus films, and the use of flying thread loom bias reinforcement of Kevlar yarns. Whereas, the performance of the Kevlar laminates was severely degraded by crease effects, significant gains in overall performance factors were shown for the coated Kevlar materials.
    Keywords: STRUCTURAL MECHANICS
    Type: NASA-CR-2738
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 4
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    Investigation of Kevlar fabric-based materials for use with inflatable structures (1977)
    In:  CASI
    Details
    Publication Date: 2019-06-27
    Description: Design, manufacture and testing of laminated and coated composite materials incorporating a structural matrix of Kevlar are reported. The practicality of using Kevlar in aerostat materials is demonstrated, and data are provided on practical weaves, lamination and coating particulars, rigidity, strength, weight, elastic coefficients, abrasion resistance, crease effects, peel strength, blocking tendencies, helium permeability, and fabrication techniques. Properties of the Kevlar-based materials are compared with conventional Dacron-reinforced counterparts. A comprehensive test and qualification program is discussed, and considerable quantitative biaxial tensile and shear test data are provided.
    Keywords: STRUCTURAL MECHANICS
    Type: NASA-CR-2724
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 5
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    Investigation of Kevlar fabric based materials for use with inflatable structures (1974)
    In:  CASI
    Details
    Publication Date: 2019-06-27
    Description: Design, manufacture and testing of laminated and coated composite materials incorporating a structural matrix of Kevlar are reported in detail. The practicality of using Kevlar in aerostat materials is demonstrated and data are provided on practical weaves, lamination and coating particulars, rigidity, strength, weight, elastic coefficients, abrasion resistance, crease effects, peel strength, blocking tendencies, helium permeability, and fabrication techniques. Properties of the Kevlar based materials are compared with conventional, Dacron reinforced counterparts. A comprehensive test and qualification program is discussed and quantitative biaxial tensile and shear test data are provided. The investigation shows that single ply laminates of Kevlar and plastic films offer significant strength to weight improvements, are less permeable than two ply coated materials, but have a lower flex life.
    Keywords: MATERIALS, NONMETALLIC
    Type: NASA-CR-132411
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 6
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    Preliminary Solar Sail Design and Fabrication Assessment: Spinning Sail Blade, Square Sail Sheet (1977)
    In:  CASI
    Details
    Publication Date: 2019-08-14
    Description: Blade design aspects most affecting producibility and means of measurement and control of length, scallop, fullness and straightness requirements and tolerances were extensively considered. Alternate designs of the panel seams and edge reinforcing members are believed to offer advantages of seam integrity, producibility, reliability, cost and weight. Approaches to and requirements for highly specialized metalizing methods, processes and equipment were studied and identified. Alternate methods of sail blade fabrication and related special machinery, tooling, fixtures and trade offs were examined. A preferred and recommended approach is also described. Quality control plans, inspection procedures, flow charts and special test equipment associated with the preferred manufacturing method were analyzed and are discussed.
    Keywords: SPACECRAFT DESIGN, TESTING AND PERFORMANCE
    Type: NASA-CR-157334
    Format: application/pdf
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    NASA TECHNICAL REPORTS
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