Publication Date:
2002-12-03
Description:
Major histocompatibility complex (mhc)-encoded molecules govern immune responses by presenting antigenic peptides to T cells. The extensive polymorphism of genes encoding these molecules is believed to enhance immune defense by broadening the array of antigenic peptides available for T cell recognition, but direct evidence supporting the importance of this mechanism in combating pathogens is limited. Here we link mhc polymorphism-driven diversification of the cytotoxic T lymphocyte (CTL) repertoire to the generation of high-avidity, protective antiviral T cells and to superior antiviral defense. Thus, much of the beneficial effect of the mhc polymorphism in immune defense may be due to its critical influence on the properties of the selected CTL repertoire.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Messaoudi, Ilhem -- Guevara Patino, Jose A -- Dyall, Ruben -- LeMaoult, Joel -- Nikolich-Zugich, Janko -- CA-86803/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2002 Nov 29;298(5599):1797-800.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Vaccine and Gene Therapy Institute and the Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12459592" target="_blank"〉PubMed〈/a〉
Keywords:
Adoptive Transfer
;
Animals
;
Complementarity Determining Regions
;
Cytotoxicity, Immunologic
;
Female
;
*Genes, MHC Class I
;
H-2 Antigens/genetics/*immunology
;
Herpes Simplex/*immunology
;
Herpesvirus 1, Human/*immunology
;
Immunity, Innate
;
Male
;
Mice
;
Mice, Inbred C57BL
;
Mice, Inbred Strains
;
*Polymorphism, Genetic
;
Receptors, Antigen, T-Cell, alpha-beta/immunology
;
T-Lymphocytes, Cytotoxic/*immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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