ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    facet.materialart.
    Unknown
    Forging future organizational leaders for sustainability science (2019)
    Springer Nature
    Details
    Publication Date: 2019
    Electronic ISSN: 2398-9629
    Topics: Biology
    Published by Springer Nature
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 2
    facet.materialart.
    Unknown
    Protection against malaria by intravenous immunization with a nonreplicating sporozoite vaccine (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-08-10
    Description: Consistent, high-level, vaccine-induced protection against human malaria has only been achieved by inoculation of Plasmodium falciparum (Pf) sporozoites (SPZ) by mosquito bites. We report that the PfSPZ Vaccine--composed of attenuated, aseptic, purified, cryopreserved PfSPZ--was safe and well tolerated when administered four to six times intravenously (IV) to 40 adults. Zero of six subjects receiving five doses and three of nine subjects receiving four doses of 1.35 x 10(5) PfSPZ Vaccine and five of six nonvaccinated controls developed malaria after controlled human malaria infection (P = 0.015 in the five-dose group and P = 0.028 for overall, both versus controls). PfSPZ-specific antibody and T cell responses were dose-dependent. These data indicate that there is a dose-dependent immunological threshold for establishing high-level protection against malaria that can be achieved with IV administration of a vaccine that is safe and meets regulatory standards.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Seder, Robert A -- Chang, Lee-Jah -- Enama, Mary E -- Zephir, Kathryn L -- Sarwar, Uzma N -- Gordon, Ingelise J -- Holman, LaSonji A -- James, Eric R -- Billingsley, Peter F -- Gunasekera, Anusha -- Richman, Adam -- Chakravarty, Sumana -- Manoj, Anita -- Velmurugan, Soundarapandian -- Li, MingLin -- Ruben, Adam J -- Li, Tao -- Eappen, Abraham G -- Stafford, Richard E -- Plummer, Sarah H -- Hendel, Cynthia S -- Novik, Laura -- Costner, Pamela J M -- Mendoza, Floreliz H -- Saunders, Jamie G -- Nason, Martha C -- Richardson, Jason H -- Murphy, Jittawadee -- Davidson, Silas A -- Richie, Thomas L -- Sedegah, Martha -- Sutamihardja, Awalludin -- Fahle, Gary A -- Lyke, Kirsten E -- Laurens, Matthew B -- Roederer, Mario -- Tewari, Kavita -- Epstein, Judith E -- Sim, B Kim Lee -- Ledgerwood, Julie E -- Graham, Barney S -- Hoffman, Stephen L -- VRC 312 Study Team -- 3R44AI055229-06S1/AI/NIAID NIH HHS/ -- 4R44AI055229-08/AI/NIAID NIH HHS/ -- 5R44AI058499-05/AI/NIAID NIH HHS/ -- N01-AI-40096/AI/NIAID NIH HHS/ -- Intramural NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2013 Sep 20;341(6152):1359-65. doi: 10.1126/science.1241800. Epub 2013 Aug 8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852, USA. rseder@mail.nih.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23929949" target="_blank"〉PubMed〈/a〉
    Keywords: Administration, Intravenous ; Adult ; Animals ; Cytokines/immunology ; Female ; Humans ; Immunity, Cellular ; Malaria Vaccines/*administration & dosage/adverse effects/*immunology ; Malaria, Falciparum/*prevention & control ; Male ; Mice ; Plasmodium falciparum/*immunology ; Sporozoites/immunology ; T-Lymphocytes/immunology ; Vaccination/adverse effects/methods
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 3
    Electronic Resource
    Electronic Resource
    Effects of sward structure on the diet selected by guanacos (Lama guanicoe) and sheep (Ovis aries) grazing a perennial ryegrass-dominated sward (1998)
    Oxford BSL : Blackwell Publishing Ltd
    Grass and forage science 53 (1998), S. 0 
    Details
    ISSN: 1365-2494
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: The effect of three different vertical structures of a perennial ryegrass-dominated sward, defined by pseudostem heights (cm) — 1·3 low (L), 2·5 medium (M) and 3·5 high (H) — on the bite depth and selection of plant parts within the grazed horizon of the sward by sheep and guanacos was studied. The bite depth (cm) was similar between sheep and guanacos across the different swards (L, 1·5; M, 3·6; H, 3·8) and was related to pre-grazing sward surface height rather than to pseudostem height. There were differences in diet composition between species that were related to differences in selection for plant parts. Sheep had a higher proportion of green leaf in the diet than did guanacos in L (0·84 vs. 0·71, P 〈 0·05) and M (0·75 vs. 0·59, P 〈 0·05) swards, and possibly selected this plant part in H swards in which the proportion of green leaf in the grazed horizon was low (0·45–0·50). Guanacos had a higher proportion of dead leaf and sheath in the diet than did sheep in L (0·23 vs. 0·09, P 〈 0·05) and M (0·30 vs. 0·18, P 〈 0·05) swards, and possibly selected this plant part on these swards, in which the proportion of green leaf in the grazed horizon was high (0·70–0·95). The proportion of pseudostem in the diet of sheep and guanacos was similar across all swards (0·03) and was generally much lower than that in the grazed horizon (0·01–0·18). Guanacos had a higher proportion of dead stem in the diet than did sheep (0·06 vs. 0·02, P 〈 0·05) across all swards, but the proportion was similar to that in the grazed horizon of each sward.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2494.1998.00099.x
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Body size dimorphism and sexual segregation in polygynous ungulates: an experimental test with Soay sheep (1999)
    Springer
    Oecologia 120 (1999), S. 258-267 
    Details
    ISSN: 1432-1939
    Keywords: Key words Allometry ; Patch selection ; Bite size ; Incisor breadth ; Intake
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Sexual segregation in Soay sheep (Ovis aries) was investigated using an experimental approach in order to test the sexual dimorphism-body size hypothesis. Two corollaries of the sexual dimorphism-body size hypothesis were tested: (1) in dimorphic species males, the larger sex, have relatively smaller bite sizes on short swards because of the scaling of incisor arcade with body weight, and (2) they move off earlier to feed on taller but poorer-quality swards when such swards are patchily distributed on a scale which enables the spatial segregation of individuals. Patch choice between sexes was estimated using a matrix of grass patches which differed in both quality and biomass of grass on offer (HQ: high-quality-low-biomass; LQ: low-quality-high-biomass). Sex differences in patch choice and grazing behaviour were tested in short-term preference trials. Incisor breadth showed no significant difference between sexes. On the other hand, muzzle width was dimorphic, with females having a narrower muzzle than males. Bite size was significantly different between the sexes, being smaller in females than in males, although it was not significantly different between sward types. Females had a higher bite rate than males and the bite rate was higher in the HQ sward type than the LQ sward type. When the effect of body mass was removed, no sex differences in muzzle size, bite size or bite rate were found. The intake rate did not differ between the sexes or between sward types. Whilst both sexes preferred the HQ sward type, females spent a significantly longer time feeding on the LQ sward type than did males. The difference detected between the sexes in patch choice was not consistent directly with the sexual dimorphism-body size hypothesis. Alternative explanations based on sex differences in foraging behaviour in relation to body mass sexual dimorphism are discussed to explain the result.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004420050856
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    The herbivores’ dilemma: trade-offs between nutrition and parasitism in foraging decisions (2000)
    Springer
    Oecologia 124 (2000), S. 242-251 
    Details
    ISSN: 1432-1939
    Keywords: Key words Grazing ; Diet selection ; Parasitism ; Sheep ; Feeding motivation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  An experiment was carried out using a trade-off framework to determine the rules of sward selection, in relation to gastrointestinal parasite dispersion, used by mammalian herbivores, and the effect of level of feeding motivation and parasitic status on these rules. Twenty-four sheep divided into four animal treatment groups resulting from two levels of feeding motivation (high and moderate) and two parasitic states (parasitised with Ostertagia circumcincta and non-parasitised) were presented with pairs of experimental swards which varied in N content (high and low), sward height (tall and short) and level of contamination with faeces and thus parasites (contaminated and non-contaminated). The selection for tall swards outweighed both the selection for N-rich swards and the avoidance of faecal contaminated swards. The selection for N-rich swards could not completely overcome faecal avoidance. Parasitism in animals with a moderate feeding motivation reduced their bite rates and grazing depths, thereby probably reducing the rate of ingestion of parasitic larvae. In contrast, highly feeding-motivated animals (including those parasitised) increased their bite rates and grazing depths, thereby increasing the rate of ingestion of parasites. The inclusion of parasite distributions, both in the environment and within herbivore host populations, is likely to advance optimal foraging theory by enhancing its predictive power.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004420000367
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Resource partitioning by ungulates on the Isle of Rhum (1989)
    Springer
    Oecologia 79 (1989), S. 383-389 
    Details
    ISSN: 1432-1939
    Keywords: Ungulate ; Seasonality ; Habitat use ; Competition ; Feeding strategies ; Resource partitioning
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary This paper describes the seasonal changes in vegetation community use by red deer, cattle, goats and ponies on the Isle of Rhum, Scotland. During the winter, when food resources were of low abundance and digestibility, the ungulates showed extensive resource partitioning. During the summer, when resource availability and digestibility was high, the grazing species, red deer, cattle and ponies congregated on the vegetation communities which contained high biomasses of a high quality resource, mesotrophic graminoids and forbs. Goats, with a digestive system adapted to dealing with browse, foraged primarily on the communities dominated by dwarf shrubs. The patterns of resource use in this group of ungulates are discussed in relation to competition; species had relatively exclusive esource use during periods of low food availability during tye winter and had a high degree of resource use overlap when food was abundant during the summer. This suggests that there was little competition for food during the summer and that exploitative competition for the high quality foods led to resource partitioning during the winter. Senarios are described which predict the pattern of resource use between two species (one competitively superior to the other on the preferred resource) utilizing mutually or exclusively preferred resources. A model developed by Illius and Gordon (1987), based on the allometry of metabolic requirements and bite size, is used to provide a mechanistic explanation for the observation that the red deer were able to exploit the high quality plant communities during the winter, whereas the cattle moved off to feed on poorer quality communities at this time.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00384318
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Comparative nutrient extraction from forages by grazing bovids and equids: a test of the nutritional model of equid/bovid competition and coexistence (1990)
    Springer
    Oecologia 84 (1990), S. 411-418 
    Details
    ISSN: 1432-1939
    Keywords: Ruminant ; Hind-gut fermenter ; Intake ; Digestion ; Competition
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Ruminants are unevenly distributed across the range of body sizes observed in herbivorous mammals; among extant East African species they predominate, in numbers and species richness, in the medium body sizes (10–600 kg). The small and the large species are all hind-gut fermenters. Some medium-sized hind-gut fermenters, equid perissodactyls, coexist with the grazing ruminants, principally bovid artiodactyls, in grassland ecosystems. These patterns have been explained by two complementary models based on differences between the digestive physiology of ruminants and hind-gut fermenters. The Demment and Van Soest (1985) model accounts for the absence of ruminants among the small and large species, while the Bell/Janis/Foose model accounts both for the predominance of ruminants, and their co-existence with equids among the medium-sized species (Bell 1971; Janis 1976; Foose 1982). The latter model assumes that the rumen is competitively superior to the hind-gut system on medium quality forages, and that hind-gut fermenters persist because of their ability to eat more, and thus to extract more nutrients per day from high fibre, low quality forages. Data presented here demonstrate that compared to similarly sized grazing ruminants (bovids), hind-gut fermenters (equids) have higher rates of food intake which more than compensate for their lesser ability to digest plant material. As a consequence equids extract more nutrients per day than bovids not only from low quality foods, but from the whole range of forages eaten by animals of this size. Neither of the current nutritional models, nor refinements of them satisfactorily explain the preponderance of the bovids among medium-sized ungulates; alternative hypotheses are presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00329768
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Modelling the nutritional ecology of ungulate herbivores: evolution of body size and competitive interactions (1992)
    Springer
    Oecologia 89 (1992), S. 428-434 
    Details
    ISSN: 1432-1939
    Keywords: Ruminant ; Hindgut fermenter ; Nutritional ecology ; Evolution ; Body size
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary A simulation model is used to quantify relationships between diet quality, digestive processes and body weight in ungulate herbivores. Retention time of food in the digestive tract is shown by regression to scale with W0.27, and to be longer in ruminants than in hindgut fermenters. Allometric relationships between whole gut mean retention time (MRT, h) and weight (W) were: MRT=9.4 W0.255 (r 2=0.80) for hindgut fermenters and MRT=15.3 W0.251 (r 2=0.76) in ruminants. Longer retention of ingesta by large-bodied ruminants and hindgut fermenters increases digestive efficiency relative to small animals and permits them to survive on lower-quality foods. Compared with ruminants, hindgut fermenters' faster throughput is an advantage which outweighs their lower digestive efficiency, particularly on poor quality foods, provided that food resources are not limiting. This suggests that the predominance of ruminants in the middle range of body weights results from their more efficient use of scarce resources under conditions of resource depletion. Considering only physical limitations on intake, the model shows that the allometric coefficient which scales energy intake to body mass is 0.88 in ruminants and 0.82 in hindgut fermenters. The advantages of large body size are countered by disadvantages where food quantity is limited, and we suggest that the upper limit to ungulate body size is determined by the ability to extract nutrients from feeding niches during the nadir of the seasonal cycle of resource quality and abundance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00317422
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Mild Conditioned Food Aversions Developed by Sheep Towards Flavors Associated with Plant Secondary Compounds (1997)
    Springer
    Journal of chemical ecology 23 (1997), S. 727-746 
    Details
    ISSN: 1573-1561
    Keywords: Conditioned flavor aversions ; condensed tannins ; intake ; oxalic acid ; plant secondary compounds ; sheep ; toxins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The objectives of the experiment were to test whether sheep develop conditioned flavor aversions (CFAs) towards a food flavor associated with the administration of a plant secondary compound, and providing that such CFAs develop, to determine how long they persist. For experimental purposes, two natural secondary compounds were used—quebracho (mainly condensed tannins) and oxalic acid—at doses previously known to produce negative postingestive consequences in sheep. The experiment consisted of four conditioning periods (each eight days long) during which the novel flavored foods (flavored hay) were offered concurrently with oral administration by gavage of the secondary compounds. In the conditioning period four groups of sheep (N = 6 each) were arranged such that each group received different flavored feeds (orange and aniseed) for two-day sequential periods. One flavor was paired with one of the model secondary compounds. Between the two sets of two days and after the second two-day period there was a period of two “rest” days, to avoid residual physiological effects of secondary compound administration. The intakes of flavored hay were recorded during each conditioning day and the effects of the secondary compounds were quantified in rumen (for volatile fatty acids and ammonia concentrations) and blood samples (for plasma calcium levels). At the end of each conditioning period, the preference for the two flavors was measured by a two-choice short-term preference test (20 min each); the persistence of the CFAs was similarly measured at 0, 10, 30 and 60 days after the completion of the conditioning with two-choice longterm preference tests (3 hr each). Results of the experiment indicated that quebracho administration did not lead to development of CFAs at the level administered. This does not necessarily reflect the sheep's inability to develop CFAs towards tannins but may reflect possible trade-offs between the ingestion of nutrients and secondary compound concentration that might have been imposed on the sheep in this experiment. In other words, it might reflect the increased familiarization with the hay (i.e., increase in its intake and hence of nutrients), which overcame the negative effects of quebracho administration. However, oxalic acid caused CFA in sheep: hay intake tended to be reduced during the days that the secondary compound was administered, and importantly the secondary compound associated flavored hay was partially avoided during the two-choice preference tests. The latter avoidance was not affected by time (consistent across conditioning periods). This CFA persisted for up to 60 days after the completion of conditioning in the absence of intervening oxalic acid exposure. Thus, sheep were able to form CFAs towards a flavor associated with the administration of a naturally occurring organic plant secondary compound.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/B:JOEC.0000006407.68081.26
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    facet.materialart.
    Unknown
    A proof of concept for structure-based vaccine design targeting RSV in humans (2019)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2019
    Description: 〈p〉Technologies that define the atomic-level structure of neutralization-sensitive epitopes on viral surface proteins are transforming vaccinology and guiding new vaccine development approaches. Previously, iterative rounds of protein engineering were performed to preserve the prefusion conformation of the respiratory syncytial virus (RSV) fusion (F) glycoprotein, resulting in a stabilized subunit vaccine candidate (DS-Cav1), which showed promising results in mice and macaques. Here, phase I human immunogenicity data reveal a more than 10-fold boost in neutralizing activity in serum from antibodies targeting prefusion-specific surfaces of RSV F. These findings represent a clinical proof of concept for structure-based vaccine design, suggest that development of a successful RSV vaccine will be feasible, and portend an era of precision vaccinology.〈/p〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...