Publication Date:
2012-04-14
Description:
During animal development, several planar cell polarity (PCP) pathways control tissue shape by coordinating collective cell behavior. Here, we characterize by means of multiscale imaging epithelium morphogenesis in the Drosophila dorsal thorax and show how the Fat/Dachsous/Four-jointed PCP pathway controls morphogenesis. We found that the proto-cadherin Dachsous is polarized within a domain of its tissue-wide expression gradient. Furthermore, Dachsous polarizes the myosin Dachs, which in turn promotes anisotropy of junction tension. By combining physical modeling with quantitative image analyses, we determined that this tension anisotropy defines the pattern of local tissue contraction that contributes to shaping the epithelium mainly via oriented cell rearrangements. Our results establish how tissue planar polarization coordinates the local changes of cell mechanical properties to control tissue morphogenesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bosveld, Floris -- Bonnet, Isabelle -- Guirao, Boris -- Tlili, Sham -- Wang, Zhimin -- Petitalot, Ambre -- Marchand, Raphael -- Bardet, Pierre-Luc -- Marcq, Philippe -- Graner, Francois -- Bellaiche, Yohanns -- New York, N.Y. -- Science. 2012 May 11;336(6082):724-7. doi: 10.1126/science.1221071. Epub 2012 Apr 12.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Polarity, Division and Morphogenesis Team, Institut Curie, CNRS UMR 3215, INSERM U934, 26 Rue d'Ulm, 75248 Paris Cedex 05, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22499807" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Anisotropy
;
Cadherins/genetics/*metabolism
;
Cell Adhesion Molecules/genetics/*metabolism
;
*Cell Polarity
;
Cell Shape
;
Drosophila Proteins/genetics/*metabolism
;
Drosophila melanogaster/cytology/genetics/*growth & development/metabolism
;
Epithelial Cells/cytology/metabolism
;
Intercellular Junctions/metabolism/physiology
;
Membrane Glycoproteins/genetics/*metabolism
;
Metamorphosis, Biological
;
Models, Biological
;
*Morphogenesis
;
Myosins/metabolism
;
Pupa/growth & development/metabolism
;
Recombinant Fusion Proteins/metabolism
;
Signal Transduction
;
Thorax/cytology/growth & development/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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