ISSN:
1573-4919
Keywords:
calmodulin
;
myelin basic protein
;
MBP
;
myristoylated alanine-rich C-kinase substrate
;
MARCKS
;
myelination
;
signal transduction
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
Notes:
Abstract Myelin basic protein (MBP) and myristoylated alanine-rich C-kinase substrate (MARCKS) are similar in terms of having extended conformations regulated by their environment (i.e., solubilised or lipid-associated), N-terminal modifications, a dual nature of interactions with lipids, binding to actin and Ca2+-calmodulin, and being substrates for different kinds of protein kinases. The further sequence similarities of segments of MBP with lipid effector regions of MARCKS, and numerous reports in the literature, support the thesis that some developmental isoform of MBP functions in signal transduction.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1007176216360
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