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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 12 (1985), S. 0 
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Gm phenotypes were examined in 90 Swedish IgA-deficient (〈0.05 g/litre of serum IgA) donors and 40 normal first and second degree relatives of six of these donors. The Glm1,2, G3m5 and Km1 frequency in the group of IgA-deficient donors did not differ from that found in the normal population. Among the relatives, HLA and/or Gm identical normal sibs were observed. Anti-IgA antibodies were present in 29 of the IgA-deficient donors and anti-IgG in seven. No association between the two was found. A statistically significant association between the Glm-2 phenotype and the presence of anti-Iga antibodies was observed. When subdivided according to HLA type, a non-random distribution of Gm phenotypes was seen in HLA-B8/DR3 positive individuals with anti-IgA antibodies (HLA-B8/DR3 being the haplotype associated with IgA deficiency). These data suggest an association between IgA deficiency, anti-IgA and the studied Gm allotypes.
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  • 2
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Five patients with T-cell CLL were investigated. At the time of sampling, no therapy had been initiated in four of the patients. Chromosome analysis (Table 1) was performed on peripheral blood lymphocytes after stimulation with a variety of T-cell activators. As the malignant T cells are of clonal ...
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  • 3
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The functional interaction of BAFF and APRIL with TNF receptor superfamily members BAFFR, TACI and BCMA is crucial for development and maintenance of humoral immunity in mice and humans. Using a candidate gene approach, we identified homozygous and heterozygous mutations in TNFRSF13B, encoding ...
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 377 (1981), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: IgA2 allotyping was performed on DNA from 60 IgA-deficient Caucasian individuals. The frequency of A2m(2) was not statistically different from that of normal controls. Two informative families were selected for further studies. In both families, the A2m(2) allotype (derived from the IgA-deficient parent) was inherited by some of the children, as determined by Southern blotting experiments. In all cases the ‘silent’ IgA2m2 gene was re-expressed, as judged by conventional serological allotyping of serum proteins. These data strongly argue against structural gene deletions or mutations as a cause of IgA deficiency.
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Calcified tissue international 2 (1968), S. 12-12 
    ISSN: 1432-0827
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
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  • 7
    ISSN: 1432-0827
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Histologische Magen- und Duodenumschnitte der Maus wurden zur gleichzeitigen Lokalisierung biogener Amine und autoradiographischem Nachweis von injiziertem3H-5-HTP benutzt. Die Radioaktivität war in den enterochromaffinen Zellen lokalisiert und in den Zellen der Magenschleimhaut am höchsten. Fluoreszenz-Intensität und Silberkörnchen-Akkumulation zeigten ein entgegengesetztes Verhalten.
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Calcified tissue international 1 (1967), S. 229-242 
    ISSN: 1432-0827
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Description / Table of Contents: Résumé La répartition de la tétracycline et du45CaCl2, injectés simultanément, a été étudiée dans les dents de rats en voie de développement, à l'aide de la microscopie à fluorescence et de l'autoradiographie. Ces deux substances s'accumulent dans l'émail, mais il existe une grande différence de distribution. La répartition du45Ca confirme la théorie des deux étapes de minéralisation et la tétracycline paraît surtout associée avec la première phase. Peu de temps après l'injection, la tétracycline et le45Ca accumulent dans une zone superficielle de matrice d'émail, venant d'être formée. De plus le45Ca est déposé dans toute l'épaisseur de certaines parties de l'émail: il n'en est pas de même pour la tétracycline. Cette accumulation de45Ca est située de côté occlusal de la zone superficielle. Entre ces deux régions, on note une zone superficielle de fluorescence augmentée et de noircissement autoradiographique. La répartition du45Ca reste identique pendant les quatre jours d'étude. Cependant la distribution de la tétracycline est nettement modifiée. Un jour après l'injection, il y a une augmentation nette de la fluorescence dans toute l'épaisseur de l'émail. Puis elle décroit graduellement, et cette diminution débute au sommet des cuspides, puis progresse du côté cervical. Après quatre jours, la fluorescence s'observe principalement dans les régions cervicales de l'émail.
    Abstract: Zusammenfassung Mittels Fluoreszenzmikroskopie und Autoradiographie wurde die Verteilung von Tetracyclin und gleichzeitig injiziertem Ca45Cl4 bei im Wachstum stehenden Rattenzähnen studiert. Beide Substanzen sammelten sich im gebildeten Zahnschmelz an, zeigten aber große Unterschiede in ihrer Verteilung. Die Verteilung von Ca45 ist im Einklang mit der Theorie von zwei Mineralisationsstufen; Tetracyclin scheint größtenteils mit der ersten Stufe verbunden zu sein Kurz nach der Injektion waren beide, Tetracyclin und Ca45 in einer oberflächlichen Zone der frischgebildeten Schmelzmatrix angereichert. Außerdem wurde Ca45 durch die ganze Dicke der anderen Schmelzschichten aufgenommen, ohne entsprechende Tetracyclinanreicherung. Diese Ca45-Aufnahme wurde an den Okklusionsstellen der oberflächlichen Zone lokalisiert. Zwischen beiden Flächen entstand eine oberflächliche Zone mit erhöhter Fluoreszenz und autoradiographischer Schwärzung. Die Ca45-Verteilung im übrigen Zahnschmelz blieb während der 4tägigen Untersuchungszeit unverändert. Dagegen war die Tetracyclin verteilung zeitlich merklich verändert. Ein Tag nach der Injektion entstand eine starke Fluoreszenzzunahme in der ganzen Schmelzschicht. Danach nahm sie graduell ab. Das Verschwinden scheint an den Spitzen der Zhanhöcker zu beginnen und gegen den Zahnhals fortzuschreiten. Nach 4 Tagen wurde die Fluoreszenz vorwiegend im Schmelz der Zahnhalspartie sichtbar.
    Notes: Abstract The distribution of tetracycline and simultaneously injected45CaCl2 has been studied in the developing teeth of rats by means of fluorescence microscopy and autoradiography. Both substances accumulated in the developing enamel, but there were great differences in their distributions. The distribution of45Ca supports the theory of two stages in the mineralization and tetracycline seemed mainly to be associated with the primary stage. Shortly after injection, both tetracycline and45Ca accumulated in a superficial zone in newly-deposited enamel matrix. In addition,45Ca was taken up throughout the wole thickness of other areas of the enamel with no corresponding accumulation of tetracycline. This uptake of45Ca was localized occlusally of the superficial zone. Between these two areas there was a superficial zone of increased fluorescence and autoradiographic blackening. The distribution of45Ca in the enamel remained unchanged during the four days of investigation. The distribution of tetracycline, however, was markedly changed with time. One day after injection there was a considerable increase in fluorescence in the whole thickness of the enamel. It then gradually decreased, and the extinction seemed to start at the tips of the cusps and proceed cervically. After four days fluorescence could be seen mainly in the cervical parts of the enamel.
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  • 10
    ISSN: 1573-4838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Cylindrical implants, made of a dense yttria-partially-stabilized zirconia/hydroxyapatite composite and a dense pure hydroxyapatite ceramic, were implanted in the mandibular bone of two beagles and the femurs of eight rabbits. Some of the cylindrical implant surfaces were drilled with a laser beam to create 200×200 μm2 dimples. The bone ingrowth and the effect of bone in the dimples on the retention of the implant in bone were studied. The histological evaluation revealed that new bone was formed in close apposition to the composite surface both in the dogs and the rabbits. The dimpled spaces of the composite were filled with the newly formed bone. The composite with dimpled surface resulted in a higher bone-bonding strength than that of the composite with a smooth surface. The bone-bonding strength was even higher than that of pure hydroxyapatite. This study showed that the laser beam drilling technique was a good machining method to produce an implant with defined surface macrostructure. The combination of bioactivity and mechanical retention in the implant material resulted in a more stable implant.
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