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  • 1
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    CLEC5A is critical for dengue-virus-induced lethal disease (2008)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2008-05-23
    Description: Dengue haemorrhagic fever and dengue shock syndrome, the most severe responses to dengue virus (DV) infection, are characterized by plasma leakage (due to increased vascular permeability) and low platelet counts. CLEC5A (C-type lectin domain family 5, member A; also known as myeloid DAP12-associating lectin (MDL-1)) contains a C-type lectin-like fold similar to the natural-killer T-cell C-type lectin domains and associates with a 12-kDa DNAX-activating protein (DAP12) on myeloid cells. Here we show that CLEC5A interacts with the dengue virion directly and thereby brings about DAP12 phosphorylation. The CLEC5A-DV interaction does not result in viral entry but stimulates the release of proinflammatory cytokines. Blockade of CLEC5A-DV interaction suppresses the secretion of proinflammatory cytokines without affecting the release of interferon-alpha, supporting the notion that CLEC5A acts as a signalling receptor for proinflammatory cytokine release. Moreover, anti-CLEC5A monoclonal antibodies inhibit DV-induced plasma leakage, as well as subcutaneous and vital-organ haemorrhaging, and reduce the mortality of DV infection by about 50% in STAT1-deficient mice. Our observation that blockade of CLEC5A-mediated signalling attenuates the production of proinflammatory cytokines by macrophages infected with DV (either alone or complexed with an enhancing antibody) offers a promising strategy for alleviating tissue damage and increasing the survival of patients suffering from dengue haemorrhagic fever and dengue shock syndrome, and possibly even other virus-induced inflammatory diseases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chen, Szu-Ting -- Lin, Yi-Ling -- Huang, Ming-Ting -- Wu, Ming-Fang -- Cheng, Shih-Chin -- Lei, Huan-Yao -- Lee, Chien-Kuo -- Chiou, Tzyy-Wen -- Wong, Chi-Huey -- Hsieh, Shie-Liang -- GM62116/GM/NIGMS NIH HHS/ -- England -- Nature. 2008 May 29;453(7195):672-6. doi: 10.1038/nature07013. Epub 2008 May 21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department and Institute of Microbiology and Immunology, National Yang-Ming University, Taipei 112, Taiwan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18496526" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Cell Adhesion Molecules/genetics/metabolism ; Cell Line ; Dengue Virus/*metabolism/*pathogenicity ; Host-Pathogen Interactions ; Humans ; Interferon-alpha ; Lectins, C-Type/antagonists & inhibitors/genetics/immunology/*metabolism ; Macrophages/virology ; Membrane Proteins/metabolism ; Mice ; Phosphorylation ; Protein Binding ; Receptors, Cell Surface/antagonists & inhibitors/genetics/immunology/*metabolism ; STAT1 Transcription Factor/deficiency/genetics ; Tumor Necrosis Factor-alpha/secretion ; Virus Replication
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 2
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    Effects of composite soil with feldspathic sandstone and sand on soil aggregates and organic carbon (2016)
    Institute of Physics (IOP)
    Details
    Publication Date: 2016-09-28
    Description: The case was to study the effects of soils with different proportions of feldspathic sandstone and sand on soil stability and organic carbon at 0-30 cm soil depth with four different ratios(C1, C2, C3 and C4), They were used to prepare the composite soil in Fu Ping, Shaanxi Province of China, then the soil aggregates distribution, WASR, MWD, GMD, D valueand and organic carbon content were measured and analysed.The results showed : the soil stability of C1, C2 and C3 was better than C4, i.e., the composition could improve the soil stability. With the increasing of the planting years, the contents of soil aggregates with the size 〉0.25 mm and MWD, GMD and SOC increased for each treatment at 0- 30 cm soil depth, which was contrary to D values. WASR of C2 was significantly higher than others (p
    Print ISSN: 1755-1307
    Electronic ISSN: 1755-1315
    Topics: Geography , Geosciences , Physics
    Published by Institute of Physics (IOP)
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  • 3
    Electronic Resource
    Electronic Resource
    Intracellular alkalinization in dexamethasone-induced thymocyte apoptosis (1997)
    Springer
    Apoptosis 2 (1997), S. 304-312 
    Details
    ISSN: 1573-675X
    Keywords: Apoptosis ; intracellular pH ; ion transporter ; thymocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Glucocorticoid can induce apoptosis of thymocytes, but its mechanism is not clear yet. In this study, we reported that dexamethasone-induced apoptosis was associated with intracellular alkalinization. Dexamethasone induced a higher percentage of apoptosis in 138 mM than in 50 mM NaCl, total abrogation of apoptosis was noted in NaCl-depleted culture medium. Highest apoptotic rate was observed in medium with pH 7.2, whereas it was partially and completely inhibited at pH 6.5 and pH 6.0, respectively. Intracellular pH was higher in pre-apoptotic thymocytes than non-apoptotic ones. The Na+ /H+ antiporter inhibitor of 5-(N,N'-dimethyl)-amiloride inhibited the dexamethasone-induced increase in pHi and apoptosis of thymocytes. Glucocorticoid antagonist RU486 also blocked the dexamethasone-induced effect. Furthermore, the apoptosis and increase in intracellular pH induced by dexamethasone were inhibited by cycloheximide, actinomycin D. It seems that intracellular pH is increased during the development of thymocyte apoptosis and inhibiting its increment would retard the rate of progression to cell death.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026441221027
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  • 4
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    Preparation and Performance of a Novel Water-Soluble Cationic Polymer Containing β-Cyclodextrin (2011)
    Wiley
    Details
    Publication Date: 2011-10-07
    Description: Allyl-β-cyclodextrin is utilized to react with dimethyl diallyl ammonium chloride and acrylamide to synthesize a novel water-soluble cationic polymer by redox free-radical polymerization. The optimum polymerization conditions are determined by the single-variable method, while the structure is characterized by Fourier transform infrared and scanning electron microscopy. In rheological experiments the polymer demonstrates superior properties compared to polyacrylamide. Interfacial tension and adsorption experiments prove the excellent performance of the polymer which can effectively decrease the interfacial tension and reduce the surfactant loss caused by stratum absorption in the process of polymer/surfactant flooding, thus indicating the potential application of the polymer for enhancing oil recovery. A novel water-soluble cationic polymer containing β-cyclodextrin was synthesized by redox free-radical polymerization. The new polymer exhibited better rheological properties than polyacrylamide and was able to decrease interfacial tension and effectively reduce the surfactant loss caused by stratum adsorption. These advantages indicate great potential applications in enhancing oil recovery.
    Print ISSN: 0930-7516
    Electronic ISSN: 1521-4125
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Published by Wiley
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  • 5
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    Photocapacitive light sensor based on metal-YMnO3-insulator-semiconductor structures (2016)
    American Institute of Physics (AIP)
    Details
    Publication Date: 2016-02-04
    Description: Technology of light sensors, due to the wide range of applications, is a dynamically developing branch of both science and industry. This work presents concept of photodetectors based on a metal-ferroelectric-insulator-semiconductor, a structure which has not been thoroughly explored in the field of photodetectors. Functionality of the presented light sensor exploits the effects of photocapacitive phenomena, ferroelectric polarization, and charge trapping. This is accomplished by an interplay between polarization alignment, subsequent charge distribution, and charge trapping processes under given illumination condition and gate voltage. Change of capacitance serves as a read out parameter indicating the wavelength and intensity of the illuminating light. The operational principle of the proposed photocapacitive light sensor is demonstrated in terms of capacitance-voltage and capacitance-time characteristics of an Al/YMnO 3 /SiN x /p-Si structure exposed to green, red, and near infrared light. Obtained results are discussed in terms of optical properties of YMnO 3 and SiN x layers contributing to the performance of photodetectors. Presented concept of light sensing might serve as the basis for the development of more advanced photodetectors.
    Print ISSN: 0003-6951
    Electronic ISSN: 1077-3118
    Topics: Physics
    Published by American Institute of Physics (AIP)
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  • 6
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    Description and evaluation of nuclear masses based on residual proton-neutron interactions (2011)
    American Physical Society (APS)
    Details
    Publication Date: 2011-09-13
    Description: Author(s): G. J. Fu, Y. Lei, H. Jiang, Y. M. Zhao, B. Sun, and A. Arima In this paper we study the residual proton-neutron interactions and make use of the systematics of these interactions to describe experimental data of nuclear masses and to predict some of the unknown masses. The odd-even effect staggering of the residual proton-neutron interaction between the last ... [Phys. Rev. C 84, 034311] Published Mon Sep 12, 2011
    Keywords: Nuclear Structure
    Print ISSN: 0556-2813
    Electronic ISSN: 1089-490X
    Topics: Physics
    Published by American Physical Society (APS)
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  • 7
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    Comment on “Pair-truncated shell-model analysis of nuclei around mass 130” (2013)
    American Physical Society (APS)
    Details
    Publication Date: 2013-03-07
    Description: Author(s): Y. Lei, H. Jiang, and Y. M. Zhao Higashiyama and Yoshinaga [ Phys. Rev. C 83 034321 (2011) ] neglected all previous studies of nuclei in the same region using the same approach (nucleon-pair-approximation calculations), the same Hamiltonian, and similar parameters. Their claim of the pair-truncated shell model as a “new approach” a... [Phys. Rev. C 87, 039801] Published Wed Mar 06, 2013
    Keywords: Nuclear Structure
    Print ISSN: 0556-2813
    Electronic ISSN: 1089-490X
    Topics: Physics
    Published by American Physical Society (APS)
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  • 8
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    IL-24 inhibits the growth of hepatoma cells in vivo (2005)
    Springer Nature
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    Publication Date: 2005-06-16
    Print ISSN: 1466-4879
    Electronic ISSN: 1476-5470
    Topics: Biology , Medicine
    Published by Springer Nature
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  • 9
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    TLR2-dependent selective autophagy regulates NF-κB lysosomal degradation in hepatoma-derived M2 macrophage differentiation (2012)
    Springer Nature
    Details
    Publication Date: 2012-11-23
    Print ISSN: 1350-9047
    Electronic ISSN: 1476-5403
    Topics: Biology , Medicine
    Published by Springer Nature
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  • 10
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    Post-evaluation of a ground source heat pump system for residential space heating in Shanghai China (2017)
    Institute of Physics (IOP)
    Details
    Publication Date: 2017-11-10
    Description: Residents of Southern China are increasingly concerned about the space heating in winter. The chief aim of the present work is to find a cost-effective way for residential space heating in Shanghai, one of the biggest city in south China. Economic and energy efficiency of three residential space heating ways, including ground source heat pump (GSHP), air source heat pump (ASHP) and wall-hung gas boiler (WHGB), are assessed based on Long-term measured data. The results show that the heat consumption of the building is 120 kWh/m 2 /y during the heating season, and the seasonal energy efficiency ratio (SEER) of the GSHP, ASHP and WHGB systems are 3.27, 2.30, 0.88 respectively. Compared to ASHP and WHGB, energy savings of GSHP during the heating season are 6.2 kgce/(m 2 .y) and 2.2 kgce/(m 2 .y), and the payback period of GSHP are 13.3 and 7.6 years respectively. The sensitivity analysis of various factors that affect the payback period is carried out, and...
    Print ISSN: 1755-1307
    Electronic ISSN: 1755-1315
    Topics: Geography , Geosciences , Physics
    Published by Institute of Physics (IOP)
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