Publication Date:
2001-06-16
Description:
The alpha subunit of a prototypical heterotrimeric GTP-binding protein (G protein), which is encoded by a single gene (GPA1) in Arabidopsis, is a modulator of plant cell proliferation. gpa1 null mutants have reduced cell division in aerial tissues throughout development. Inducible overexpression of GPA1 in Arabidopsis confers inducible ectopic cell division. GPA1 overexpression in synchronized BY-2 cells causes premature advance of the nuclear cycle and the premature appearance of a division wall. Results from loss of function and ectopic expression and activation of GPA1 indicate that this subunit is a positive modulator of cell division in plants.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ullah, H -- Chen, J G -- Young, J C -- Im, K H -- Sussman, M R -- Jones, A M -- New York, N.Y. -- Science. 2001 Jun 15;292(5524):2066-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11408654" target="_blank"〉PubMed〈/a〉
Keywords:
2,4-Dichlorophenoxyacetic Acid/pharmacology
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Alleles
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Arabidopsis/*cytology/genetics/growth & development/*metabolism
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*Arabidopsis Proteins
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Cell Size
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*GTP-Binding Protein alpha Subunits
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Genes, Plant
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Genes, Reporter
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Glucuronidase/analysis/genetics
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Guanosine Triphosphate/metabolism
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Heterotrimeric GTP-Binding Proteins/chemistry/genetics/*metabolism
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Indoleacetic Acids/pharmacology
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Light
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MAP Kinase Signaling System
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Morphogenesis
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Mutation
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Peptides/pharmacology
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Phenotype
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Plant Leaves/cytology/growth & development
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Plants, Toxic
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Protein Subunits
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Recombinant Proteins/metabolism
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Signal Transduction
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Tobacco
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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