ISSN:
0009-2940
Keywords:
CC-1065
;
Antitumor antibiotics
;
Zirconocene-induced cyclisation
;
Indolines
;
Chemistry
;
Inorganic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The synthesis of the reduced A-unit 2 (CI) of CC-1065 (1) using a metal-mediated cyclisation is described. Reaction of N-allyl-N-benzylaniline 4b and zirconocene(methyl) chloride with tert-BuLi leads via a zirconocene-stabilized benzyne complex 5 to the 3,4-difunctionalized indoline derivative 7, which was converted in five steps into 2.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/cber.19931261224
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