ISSN:
1432-1211
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Genomic DNA from a large panel of inbred strains of mice were hybridized sequentially with 15 Vα, 2 Vδ, 1 Cα, and 1 Cδ probes. Most of the Vα probes detected a high degree of plymorphism and have allowed the definition of five mouse T-cell receptor α (Tcr α) haplotypes. One of these haplotypes (Tcr α e ) appears to arise from a recombination between theTcr α b andTcr α a haplotypes, the latter being the most frequently found in the conventional inbred strains. This recombination event clearly indicates that the members of at least 11 Vα subfamilies are not closely linked but highly interspersed with one another on chromosome 14.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02421537
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