ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    facet.materialart.
    Unknown
    Microstructural view of burrowing with a bioinspired digging robot (2015)
    American Physical Society (APS)
    Details
    Publication Date: 2015-10-23
    Description: Author(s): K. N. Nordstrom, D. S. Dorsch, W. Losert, and A. G. Winter, V RoboClam is a burrowing technology inspired by Ensis directus , the Atlantic razor clam. Atlantic razor clams should only be strong enough to dig a few centimeters into the soil, yet they burrow to over 70 cm. The animal uses a clever trick to achieve this: by contracting its body, it agitates and lo… [Phys. Rev. E 92, 042204] Published Thu Oct 22, 2015
    Keywords: Granular Materials
    Print ISSN: 1539-3755
    Electronic ISSN: 1550-2376
    Topics: Physics
    Published by American Physical Society (APS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 2
    facet.materialart.
    Unknown
    3D plausible orbital stability close to asteroid (216) Kleopatra (2015)
    Oxford University Press
    Details
    Publication Date: 2015-07-16
    Description: Recent data processing showed the existence of a difference that can reach 25 per cent for the dimensions of asteroid (216) Kleopatra between the radar observations and the light curves. We rebuild the shape of (216) Kleopatra from these new data applying a correction's factor of the size of 1.15 and estimate certain physical features by using the polyhedral model method. In our computations, we use a code that avoids singularities from the line integrals of a homogeneous arbitrary shaped polyhedral source. Then, we find the location of the equilibrium points through the pseudo-potential energy and zero-velocity curves. The behaviour of the zero-velocity curves differ substantially if we apply a scale size of 1.15 relative to the original shape of (216) Kleopatra. Taking the rotation of asteroid (216) Kleopatra into consideration, the aim of this work is to analyse the stability against impact and the dynamics of numerical simulations of 3D initially equatorial and polar orbits near the body. As results, we show that the minimum radii are more suited for the stability against impact. We find also that the minimum radius for direct, equatorial circular orbits that cannot impact with (216) Kleopatra surface is 300 km and the lower limit on radius for polar circular orbits is 240 km. Stable orbits occur at 280 km for equatorial circular orbits despite significant perturbations of its orbit. Moreover, as the orbits suffer less perturbations due to the irregular gravitational potential of (216) Kleopatra in the elliptic case, the most significant result of the analysis is that stable orbits exist at a periapsis radius of 250 km for initial eccentricities e i  = 0.2 in both cases. Finally, the polar orbits with eccentricities ranging between 0.1 and 0.2 appear to be more stable.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
    Published by Oxford University Press
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 3
    facet.materialart.
    Unknown
    Stonin 2-mediated synaptotagmin sorting [Neuroscience] (2013)
    National Academy of Sciences
    Details
    Publication Date: 2013-02-06
    Description: Neurotransmission depends on the exocytic fusion of synaptic vesicles (SVs) and their subsequent reformation either by clathrin-mediated endocytosis or budding from bulk endosomes. How synapses are able to rapidly recycle SVs to maintain SV pool size, yet preserve their compositional identity, is poorly understood. We demonstrate that deletion of the...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 4
    facet.materialart.
    Unknown
    Ionization and excitation in collisions between antiprotons and H(1s) atoms studied with Sturmian bases (2011)
    American Physical Society (APS)
    Details
    Publication Date: 2011-02-15
    Description: Author(s): Thomas G. Winter Coupled two-center as well as one-center Sturmian cross sections have been determined for ionization and excitation in p̄-H(1s) collisions at p̄ energies from 1 to 16 000 keV, following the author’s recent work for p-H(1s) collisions [Phys. Rev. A 80, 032701 (2009)]. Basis convergence is studie... [Phys. Rev. A 83, 022709] Published Mon Feb 14, 2011
    Keywords: Atomic and molecular collisions and interactions
    Print ISSN: 1050-2947
    Electronic ISSN: 1094-1622
    Topics: Physics
    Published by American Physical Society (APS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 5
    facet.materialart.
    Unknown
    Water, Vol. 11, Pages 1195: Energy Reduction and Uniformity of Low-Pressure Online Drip Irrigation Emitters in Field Tests (2019)
    MDPI
    In: Water
    Details
    Publication Date: 2019
    Description: A promising way of addressing the issue of growing water scarcity is through wider use of drip irrigation, which delivers water and fertilizer to crops in a slow, targeted manner, and has been shown to increase yields and water use efficiency. Yet, drip irrigation system adoption is low, primarily due to the high capital cost of the pressurized piping network and the pump, and operating energy cost. Lowering the water pressure needed for drip emitters to deliver water can reduce both capital and operating costs of drip systems. Here we present the results from field trials of new pressure-compensating online drip emitters that operate with a minimum compensating inlet pressure of 15 kPa (0.15 bar), in comparison to typical commercial emitters with minimum pressures of 50–100 kPa (0.5–1.0 bar). The field trials were carried out on nine farms in Morocco and Jordan over the course of one irrigation season with freshwater and treated wastewater. Low-pressure emitters are shown to reduce hydraulic energy per unit volume of water delivered by 43% on average compared to commercial emitters, without significantly sacrificing water emission uniformity (low-pressure emitters show uniformities of 81–91%, compared to 87–96% for commercial emitters). This energy reduction could lead to savings of 22–31% in the capital cost of a pump and emitters and the energy cost for a typical drip irrigation system. Thus, the low-pressure online emitters can be used as substitutes to commercial emitters that require higher water pressures, leading to reduced environmental impact and lower system costs.
    Electronic ISSN: 2073-4441
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Published by MDPI
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 6
    facet.materialart.
    Unknown
    3D stability orbits close to 433 Eros using an effective polyhedral model method (2014)
    Oxford University Press
    Details
    Publication Date: 2014-02-15
    Description: One of the techniques used in the past decade to determine the shape with a good accuracy and estimate certain physical features (volume, mass, moments of inertia) of asteroids is the polyhedral model method. We rebuild the shape of the asteroid 433 Eros using data from 1998 December observations of the probe Near-Earth-Asteroid-Rendezvous-Shoemaker . In our computations, we use a code that avoids singularities from the line integrals of a homogeneous arbitrary shaped polyhedral source. This code evaluates the gravitational potential function and its first- and second-order derivatives. Taking the rotation of asteroid 433 Eros into consideration, the aim of this work is to analyse the dynamics of numerical simulations of 3D initially equatorial orbits near the body. We find that the minimum radius for direct, equatorial circular orbits that cannot impact with the Eros surface is 36 km and the minimum radius for stable orbits is 31 km despite significant perturbations of its orbit. Moreover, as the orbits suffer less perturbations due to the irregular gravitational potential of Eros in the elliptic case, the most significant result of the analysis is that stable orbits exist at a periapsis radius of 29 km for initial eccentricities e i ≤ 0.2.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
    Published by Oxford University Press
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 7
    facet.materialart.
    Unknown
    Reshaping human antibodies: grafting an antilysozyme activity (1988)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1988-03-25
    Description: The production of therapeutic human monoclonal antibodies by hybridoma technology has proved difficult, and this has prompted the "humanizing" of mouse monoclonal antibodies by recombinant DNA techniques. It was shown previously that the binding site for a small hapten could be grafted from the heavy-chain variable domain of a mouse antibody to that of a human myeloma protein by transplanting the hypervariable loops. It is now shown that a large binding site for a protein antigen (lysozyme) can also be transplanted from mouse to human heavy chain. The success of such constructions may be facilitated by an induced-fit mechanism.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Verhoeyen, M -- Milstein, C -- Winter, G -- New York, N.Y. -- Science. 1988 Mar 25;239(4847):1534-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Medical Research Council Laboratory of Molecular Biology, Cambridge, England.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2451287" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Antibodies, Monoclonal/genetics/immunology ; Base Sequence ; Binding Sites, Antibody ; Binding, Competitive ; Cloning, Molecular ; DNA, Recombinant ; Epitopes/immunology ; Humans ; Immunoglobulin G/genetics/immunology ; Immunoglobulin Variable Region/genetics ; Mice ; Molecular Sequence Data ; Muramidase/*immunology ; Plasmids ; Recombinant Proteins ; Transfection
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 8
    facet.materialart.
    Unknown
    NOD1 and NOD2 signalling links ER stress with inflammation (2016)
    Springer Nature
    In: Nature
    Details
    Publication Date: 2016-04-21
    Description: NOD1 and NOD2 signalling links ER stress with inflammation Nature 532, 7599 (2016). doi:10.1038/nature17631 Authors: A. Marijke Keestra-Gounder, Mariana X. Byndloss, Núbia Seyffert, Briana M. Young, Alfredo Chávez-Arroyo, April Y. Tsai, Stephanie A. Cevallos, Maria G. Winter, Oanh H. Pham, Connor R. Tiffany, Maarten F. de Jong, Tobias Kerrinnes, Resmi Ravindran, Paul A. Luciw, Stephen J. McSorley, Andreas J. Bäumler & Renée M. Tsolis Endoplasmic reticulum (ER) stress is a major contributor to inflammatory diseases, such as Crohn disease and type 2 diabetes. ER stress induces the unfolded protein response, which involves activation of three transmembrane receptors, ATF6, PERK and IRE1α. Once activated, IRE1α recruits TRAF2 to the ER membrane to initiate inflammatory responses via the NF-κB pathway. Inflammation is commonly triggered when pattern recognition receptors (PRRs), such as Toll-like receptors or nucleotide-binding oligomerization domain (NOD)-like receptors, detect tissue damage or microbial infection. However, it is not clear which PRRs have a major role in inducing inflammation during ER stress. Here we show that NOD1 and NOD2, two members of the NOD-like receptor family of PRRs, are important mediators of ER-stress-induced inflammation in mouse and human cells. The ER stress inducers thapsigargin and dithiothreitol trigger production of the pro-inflammatory cytokine IL-6 in a NOD1/2-dependent fashion. Inflammation and IL-6 production triggered by infection with Brucella abortus, which induces ER stress by injecting the type IV secretion system effector protein VceC into host cells, is TRAF2, NOD1/2 and RIP2-dependent and can be reduced by treatment with the ER stress inhibitor tauroursodeoxycholate or an IRE1α kinase inhibitor. The association of NOD1 and NOD2 with pro-inflammatory responses induced by the IRE1α/TRAF2 signalling pathway provides a novel link between innate immunity and ER-stress-induced inflammation.
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Springer Nature
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 9
    facet.materialart.
    Unknown
    Structure of the human histamine H1 receptor complex with doxepin (2011)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2011-06-24
    Description: The biogenic amine histamine is an important pharmacological mediator involved in pathophysiological processes such as allergies and inflammations. Histamine H(1) receptor (H(1)R) antagonists are very effective drugs alleviating the symptoms of allergic reactions. Here we show the crystal structure of the H(1)R complex with doxepin, a first-generation H(1)R antagonist. Doxepin sits deep in the ligand-binding pocket and directly interacts with Trp 428(6.48), a highly conserved key residue in G-protein-coupled-receptor activation. This well-conserved pocket with mostly hydrophobic nature contributes to the low selectivity of the first-generation compounds. The pocket is associated with an anion-binding region occupied by a phosphate ion. Docking of various second-generation H(1)R antagonists reveals that the unique carboxyl group present in this class of compounds interacts with Lys 191(5.39) and/or Lys 179(ECL2), both of which form part of the anion-binding region. This region is not conserved in other aminergic receptors, demonstrating how minor differences in receptors lead to pronounced selectivity differences with small molecules. Our study sheds light on the molecular basis of H(1)R antagonist specificity against H(1)R.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131495/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131495/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shimamura, Tatsuro -- Shiroishi, Mitsunori -- Weyand, Simone -- Tsujimoto, Hirokazu -- Winter, Graeme -- Katritch, Vsevolod -- Abagyan, Ruben -- Cherezov, Vadim -- Liu, Wei -- Han, Gye Won -- Kobayashi, Takuya -- Stevens, Raymond C -- Iwata, So -- 062164/ Z/00/Z/Wellcome Trust/United Kingdom -- BB/G023425/1/Biotechnology and Biological Sciences Research Council/United Kingdom -- P50 GM073197/GM/NIGMS NIH HHS/ -- P50 GM073197-07/GM/NIGMS NIH HHS/ -- R01 GM071872/GM/NIGMS NIH HHS/ -- R01 GM071872-02/GM/NIGMS NIH HHS/ -- R01 GM071872-08/GM/NIGMS NIH HHS/ -- R01 GM089857/GM/NIGMS NIH HHS/ -- U54 GM094618/GM/NIGMS NIH HHS/ -- U54 GM094618-01/GM/NIGMS NIH HHS/ -- England -- Nature. 2011 Jun 22;475(7354):65-70. doi: 10.1038/nature10236.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Human Receptor Crystallography Project, ERATO, Japan Science and Technology Agency, Kyoto 606-8501, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21697825" target="_blank"〉PubMed〈/a〉
    Keywords: Binding Sites ; Crystallography, X-Ray ; Doxepin/chemistry/*metabolism ; Histamine Antagonists/chemistry/*metabolism ; Humans ; Hydrophobic and Hydrophilic Interactions ; Isomerism ; Ligands ; Models, Molecular ; Phosphates/chemistry/metabolism ; Protein Binding ; Protein Conformation ; Receptors, Adrenergic, beta-2/chemistry ; Receptors, Dopamine D3/chemistry ; Receptors, Histamine H1/*chemistry/*metabolism ; Substrate Specificity
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 10
    facet.materialart.
    Unknown
    Manipulation of small Rho GTPases is a pathogen-induced process detected by NOD1 (2013)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2013-04-02
    Description: Our innate immune system distinguishes microbes from self by detecting conserved pathogen-associated molecular patterns. However, these are produced by all microbes, regardless of their pathogenic potential. To distinguish virulent microbes from those with lower disease-causing potential the innate immune system detects conserved pathogen-induced processes, such as the presence of microbial products in the host cytosol, by mechanisms that are not fully resolved. Here we show that NOD1 senses cytosolic microbial products by monitoring the activation state of small Rho GTPases. Activation of RAC1 and CDC42 by bacterial delivery or ectopic expression of SopE, a virulence factor of the enteric pathogen Salmonella, triggered the NOD1 signalling pathway, with consequent RIP2 (also known as RIPK2)-mediated induction of NF-kappaB-dependent inflammatory responses. Similarly, activation of the NOD1 signalling pathway by peptidoglycan required RAC1 activity. Furthermore, constitutively active forms of RAC1, CDC42 and RHOA activated the NOD1 signalling pathway. Our data identify the activation of small Rho GTPases as a pathogen-induced process sensed through the NOD1 signalling pathway.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625479/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625479/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Keestra, A Marijke -- Winter, Maria G -- Auburger, Josef J -- Frassle, Simon P -- Xavier, Mariana N -- Winter, Sebastian E -- Kim, Anita -- Poon, Victor -- Ravesloot, Marietta M -- Waldenmaier, Julian F T -- Tsolis, Renee M -- Eigenheer, Richard A -- Baumler, Andreas J -- AI044170/AI/NIAID NIH HHS/ -- AI076246/AI/NIAID NIH HHS/ -- R01 AI044170/AI/NIAID NIH HHS/ -- R01 AI076246/AI/NIAID NIH HHS/ -- England -- Nature. 2013 Apr 11;496(7444):233-7. doi: 10.1038/nature12025. Epub 2013 Mar 31.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, One Shields Avenue, Davis, California 95616, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23542589" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bacterial Proteins/metabolism ; Cytosol/metabolism ; Female ; HEK293 Cells ; HSP90 Heat-Shock Proteins/metabolism ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; NF-kappa B/metabolism ; Nod1 Signaling Adaptor Protein/*metabolism ; Nod2 Signaling Adaptor Protein/metabolism ; Peptidoglycan/metabolism ; Receptor-Interacting Protein Serine-Threonine Kinase 2/metabolism ; Salmonella typhimurium/genetics/*metabolism/*pathogenicity ; Signal Transduction ; Virulence Factors/metabolism ; cdc42 GTP-Binding Protein/metabolism ; rac1 GTP-Binding Protein/metabolism ; rho GTP-Binding Proteins/*metabolism ; rhoA GTP-Binding Protein/metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...