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  • 1
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    Angiogenesis-independent endothelial protection of liver: role of VEGFR-1 (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-02-08
    Description: The vascular endothelium was once thought to function primarily in nutrient and oxygen delivery, but recent evidence suggests that it may play a broader role in tissue homeostasis. To explore the role of sinusoidal endothelial cells (LSECs) in the adult liver, we studied the effects of vascular endothelial growth factor (VEGF) receptor activation on mouse hepatocyte growth. Delivery of VEGF-A increased liver mass in mice but did not stimulate growth of hepatocytes in vitro, unless LSECs were also present in the culture. Hepatocyte growth factor (HGF) was identified as one of the LSEC-derived paracrine mediators promoting hepatocyte growth. Selective activation of VEGF receptor-1 (VEGFR-1) stimulated hepatocyte but not endothelial proliferation in vivo and reduced liver damage in mice exposed to a hepatotoxin. Thus, VEGFR-1 agonists may have therapeutic potential for preservation of organ function in certain liver disorders.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉LeCouter, Jennifer -- Moritz, Dirk R -- Li, Bing -- Phillips, Gail Lewis -- Liang, Xiao Huan -- Gerber, Hans-Peter -- Hillan, Kenneth J -- Ferrara, Napoleone -- New York, N.Y. -- Science. 2003 Feb 7;299(5608):890-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Departments of Molecular Oncology, Protein Engineering, and Pathology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12574630" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; CHO Cells ; Carbon Tetrachloride/toxicity ; Cell Division ; Cells, Cultured ; Coculture Techniques ; Cricetinae ; DNA Replication ; Drug-Induced Liver Injury ; Endothelial Growth Factors/genetics/*metabolism/pharmacology ; Endothelium, Vascular/*cytology/physiology ; Gene Expression Regulation ; Growth Substances/genetics/metabolism ; Hepatocyte Growth Factor/genetics/metabolism/pharmacology ; Hepatocytes/cytology/pathology/*physiology ; Humans ; Intercellular Signaling Peptides and Proteins/genetics/*metabolism/pharmacology ; Liver/blood supply/*cytology/pathology/*physiology ; Liver Diseases/metabolism/pathology/prevention & control ; Liver Regeneration ; Lymphokines/genetics/*metabolism/pharmacology ; Mice ; Mice, Nude ; Mitosis ; Mutation ; Necrosis ; Neovascularization, Physiologic ; Paracrine Communication ; RNA, Messenger/genetics/metabolism ; Signal Transduction ; Up-Regulation ; Vascular Endothelial Growth Factor A ; Vascular Endothelial Growth Factor Receptor-1/*metabolism ; Vascular Endothelial Growth Factor Receptor-2/metabolism ; Vascular Endothelial Growth Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
    Electronic Resource
    Electronic Resource
    The Use of Redox Potential to Control Ferric Sulphate Dosing during Phosphate Removal (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Water and environment journal 3 (1989), S. 0 
    Details
    ISSN: 1747-6593
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: In recent years, the Norfolk Broads have been enriched with sewage effluent and runoff from heavily fertilized land. Nitrogen and phosphorus compounds from these sources can cause ecological problems by stimulating increase in algal biomass in the water, so part of Anglian Water's programme of research in Broadland has been to remove phosphate from major sewage effluents discharged to the Rivers Ant and Bure. This is achieved by dosing ferric sulphate to secondary effluent and settling the resultant insoluble complex.At three sites on the River Bure, the performance of timeclock- and redox-based dose control systems was evaluated. Redox control, by restricting dosing when phosphate load was low, increased the efficiency of phosphate removal and produced up to 19 per cent savings in chemical costs. Modifications are described which made the system self-regulating and ensured that savings were not eroded by maintenance costs. The system now operates efficiently and routinely at major sites on the Rivers Ant and Bure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1747-6593.1989.tb01545.x
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  • 3
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    An integrated pan-tropical biomass map using multiple reference datasets (2015)
    Wiley
    Details
    Publication Date: 2015-10-27
    Description: We combined two existing datasets of vegetation aboveground biomass (AGB) (Saatchi et al., 2011; Baccini et al., 2012) into a pan-tropical AGB map at 1-km resolution using an independent reference dataset of field observations and locally-calibrated high-resolution biomass maps, harmonized and upscaled to 14,477 1-km AGB estimates. Our data fusion approach uses bias removal and weighted linear averaging that incorporates and spatializes the biomass patterns indicated by the reference data. The method was applied independently in areas (strata) with homogeneous error patterns of the input (Saatchi and Baccini) maps, which were estimated from the reference data and additional covariates. Based on the fused map, we estimated AGB stock for the tropics (23.4 N – 23.4 S) of 375 Pg dry mass, 9% - 18% lower than the Saatchi and Baccini estimates. The fused map also showed differing spatial patterns of AGB over large areas, with higher AGB density in the dense forest areas in the Congo basin, Eastern Amazon and South-East Asia, and lower values in Central America and in most dry vegetation areas of Africa than either of the input maps. The validation exercise, based on 2,118 estimates from the reference dataset not used in the fusion process, showed that the fused map had a RMSE 15 – 21% lower than that of the input maps and, most importantly, nearly unbiased estimates (mean bias 5 Mg dry mass ha −1 vs. 21 and 28 Mg ha −1 for the input maps). The fusion method can be applied at any scale including the policy-relevant national level, where it can provide improved biomass estimates by integrating existing regional biomass maps as input maps and additional, country-specific reference datasets. This article is protected by copyright. All rights reserved.
    Print ISSN: 1354-1013
    Electronic ISSN: 1365-2486
    Topics: Biology , Energy, Environment Protection, Nuclear Power Engineering , Geography
    Published by Wiley
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  • 4
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    The Mineral Nutrient Levels in Three Norfolk Broads Differing in Trophic Status, and an Annual Mineral Content Budget for One of Them (1977)
    Wiley
    Details
    Publication Date: 1977-07-01
    Print ISSN: 0022-0477
    Electronic ISSN: 1365-2745
    Topics: Biology
    Published by Wiley on behalf of British Ecological Society.
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  • 5
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    Ecology of European Rivers. (1986)
    Wiley
    Details
    Publication Date: 1986-03-01
    Print ISSN: 0022-0477
    Electronic ISSN: 1365-2745
    Topics: Biology
    Published by Wiley on behalf of British Ecological Society.
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