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  • 1
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    Synaptic dysfunction in depression: potential therapeutic targets (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-10-09
    Description: Basic and clinical studies demonstrate that depression is associated with reduced size of brain regions that regulate mood and cognition, including the prefrontal cortex and the hippocampus, and decreased neuronal synapses in these areas. Antidepressants can block or reverse these neuronal deficits, although typical antidepressants have limited efficacy and delayed response times of weeks to months. A notable recent discovery shows that ketamine, a N-methyl-D-aspartate receptor antagonist, produces rapid (within hours) antidepressant responses in patients who are resistant to typical antidepressants. Basic studies show that ketamine rapidly induces synaptogenesis and reverses the synaptic deficits caused by chronic stress. These findings highlight the central importance of homeostatic control of mood circuit connections and form the basis of a synaptogenic hypothesis of depression and treatment response.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424898/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424898/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Duman, Ronald S -- Aghajanian, George K -- R01 MH093897/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2012 Oct 5;338(6103):68-72. doi: 10.1126/science.1222939.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT 06508, USA. ronald.duman@yale.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23042884" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antidepressive Agents/*administration & dosage ; Atrophy/pathology ; Behavior/drug effects ; Depressive Disorder, Major/*drug therapy/pathology/*physiopathology ; Homeostasis/drug effects ; Humans ; Mice ; Neurons/pathology ; Stress, Psychological/pathology/physiopathology ; Synapses/*drug effects/pathology/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Molecular and cellular basis of addiction (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-10-06
    Description: Drug addiction results from adaptations in specific brain neurons caused by repeated exposure to a drug of abuse. These adaptations combine to produce the complex behaviors that define an addicted state. Progress is being made in identifying such time-dependent, drug-induced adaptations and relating them to specific behavioral features of addiction. Current research needs to understand the types of adaptations that underlie the particularly long-lived aspects of addiction, such as drug craving and relapse, and to identify specific genes that contribute to individual differences in vulnerability to addiction. Understanding the molecular and cellular basis of addictive states will lead to major changes in how addiction is viewed and ultimately treated.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nestler, E J -- Aghajanian, G K -- New York, N.Y. -- Science. 1997 Oct 3;278(5335):58-63.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, 34 Park Street, New Haven, CT 06508, USA. eric.nestler@qm.yale.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9311927" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Physiological ; Animals ; Brain/*drug effects/metabolism ; Cyclic AMP/metabolism ; Down-Regulation ; GTP-Binding Proteins/metabolism ; Humans ; Receptors, Neurotransmitter/metabolism ; Street Drugs/*pharmacology ; Substance-Related Disorders/*metabolism ; Synaptic Transmission ; Up-Regulation
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Tricyclic antidepressants: long-term treatment increases responsivity of rat forebrain neurons to serotonin (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-22
    Description: Long-term treatment of rats with clinically effective tricyclic antidepressant drugs induced a selective increase in the inhibitory response of forebrain neurons to serotonin applied by microiontophoresis. Long-term administration of some related drugs which lack antidepressant efficacy failed to induce such a change. The enhanced response to serotonin induced by the clinically active tricyclic drugs took 1 to 2 weeks to develop, a time course which correlates with the delayed onset of therapeutic effects in humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉de Montigny, C -- Aghajanian, G K -- New York, N.Y. -- Science. 1978 Dec 22;202(4374):1303-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/725608" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials/drug effects ; Animals ; Antidepressive Agents, Tricyclic/*pharmacology ; Decerebrate State ; Drug Synergism ; Geniculate Bodies/*drug effects ; Hippocampus/*drug effects ; Male ; Neural Inhibition/drug effects ; Norepinephrine/pharmacology ; Pyramidal Tracts/drug effects ; Rats ; Receptors, Serotonin/*drug effects ; Serotonin/*pharmacology ; gamma-Aminobutyric Acid/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    alpha 2-adrenoceptor-mediated hyperpolarization of locus coeruleus neurons: intracellular studies in vivo (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-03-12
    Description: Intracellular recordings in vivo from noradrenergic neurons in the rat locus coeruleus showed that membrane potential was hyperpolarized by the administration of clonidine (an alpha 2-adrenoceptor agonist) or after a burst of spikes evoked by intracellular pulses; both types of hyperpolarization were associated with a decrease in membrane input resistance, and both could be blocked by the alpha 2-adrenoceptor antagonist piperoxane. These results suggest that a hyperpolarization of membrane potential mediated by an alpha 2-adrenoceptor underlies both clonidine- and activation-induced inhibition of locus coeruleus cell firing.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Aghajanian, G K -- VanderMaelen, C P -- MH-14276/MH/NIMH NIH HHS/ -- MH-14459/MH/NIMH NIH HHS/ -- MH-17871/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1982 Mar 12;215(4538):1394-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6278591" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Clonidine/pharmacology ; Locus Coeruleus/*physiology ; Male ; Membrane Potentials/drug effects ; Piperoxan/pharmacology ; Rats ; Receptors, Adrenergic/*physiology ; Receptors, Adrenergic, alpha/*physiology ; Sympathetic Nervous System/*physiology ; Synaptic Transmission/drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
    Electronic Resource
    Electronic Resource
    Electrophysiology of the Central Serotonin System: Receptor Subtypes and Transducer Mechanisms (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 600 (1990), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1990.tb16875.x
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    LSD and CNS Transmission (1972)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Pharmacology 12 (1972), S. 157-168 
    Details
    ISSN: 0362-1642
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.pa.12.040172.001105
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  • 7
    Electronic Resource
    Electronic Resource
    Stimulation of pontine reticular formation suppresses firing of serotonergic neurones in the dorsal raphe (1976)
    [s.l.] : Nature Publishing Group
    Nature 264 (1976), S. 365-368 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Evidence from lesion1?3 and stimulation4?5 studies suggests that the PRF is important in the generation of rapid eye movement (REM) or desynchronised sleep (DS). Hobson et al.6?8 have found that cells in the PRF selectively increased their firing just before the onset of DS and maintained their ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/264365a0
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  • 8
    Electronic Resource
    Electronic Resource
    An osmiophilic substance in brain synaptic vesicles not associated with catecholamine content (1968)
    Springer
    Cellular and molecular life sciences 24 (1968), S. 1225-1227 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Nach Fixierung durch Glutaraldehyddurchströmung und Behandlung mit OsO4 bei 60°C während 30 min erhält man im Rattenhirn elektronendichte Niederschläge innerhalb der kleinen synaptischen Vesikel. Amin-Entleerungsversuche und autoradiographische Untersuchungen haben gezeigt, dass diese Niederschläge nicht mit dem Katecholamingehalt des Gehirns zusammenhängen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02146636
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  • 9
    Electronic Resource
    Electronic Resource
    Modulation of a transient outward current in serotonergic neurones by α 1 -adrenoceptors (1985)
    [s.l.] : Nature Publishing Group
    Nature 315 (1985), S. 501-503 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Rat serotonergic dorsal raphe neurones, investigated in voltage-clamp conditions (see Fig. 1 legend), exhibited an early transient outward current with the characteristics of /A as originally described in molluscan neurones3'4. This current could be evoked by depolarizations from holding potentials ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/315501a0
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  • 10
    Electronic Resource
    Electronic Resource
    Intracellular studies showing modulation of facial motoneurone excitability by serotonin (1980)
    [s.l.] : Nature Publishing Group
    Nature 287 (1980), S. 346-347 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Figure 1 illustrates the changes which occurred in a rat facial motoneurone with the iontophoretic administration of a relatively low dose (+25 nA ejection current) of serotonin. Within 32 s, the resting potential shifted from -68 mV to -63.5 mV (Fig. 16), input resistance increased by 32% from an ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/287346a0
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