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  • 1
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    Antibodies to PfSEA-1 block parasite egress from RBCs and protect against malaria infection (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-05-24
    Description: Novel vaccines are urgently needed to reduce the burden of severe malaria. Using a differential whole-proteome screening method, we identified Plasmodium falciparum schizont egress antigen-1 (PfSEA-1), a 244-kilodalton parasite antigen expressed in schizont-infected red blood cells (RBCs). Antibodies to PfSEA-1 decreased parasite replication by arresting schizont rupture, and conditional disruption of PfSEA-1 resulted in a profound parasite replication defect. Vaccination of mice with recombinant Plasmodium berghei PbSEA-1 significantly reduced parasitemia and delayed mortality after lethal challenge with the Plasmodium berghei strain ANKA. Tanzanian children with antibodies to recombinant PfSEA-1A (rPfSEA-1A) did not experience severe malaria, and Kenyan adolescents and adults with antibodies to rPfSEA-1A had significantly lower parasite densities than individuals without these antibodies. By blocking schizont egress, PfSEA-1 may synergize with other vaccines targeting hepatocyte and RBC invasion.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184151/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184151/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Raj, Dipak K -- Nixon, Christian P -- Nixon, Christina E -- Dvorin, Jeffrey D -- DiPetrillo, Christen G -- Pond-Tor, Sunthorn -- Wu, Hai-Wei -- Jolly, Grant -- Pischel, Lauren -- Lu, Ailin -- Michelow, Ian C -- Cheng, Ling -- Conteh, Solomon -- McDonald, Emily A -- Absalon, Sabrina -- Holte, Sarah E -- Friedman, Jennifer F -- Fried, Michal -- Duffy, Patrick E -- Kurtis, Jonathan D -- 1K08AI100997-01A1/AI/NIAID NIH HHS/ -- DP2 AI112219/AI/NIAID NIH HHS/ -- DP2-AI112219/AI/NIAID NIH HHS/ -- K08 AI100997/AI/NIAID NIH HHS/ -- P20GM103421/GM/NIGMS NIH HHS/ -- P30 AI042853/AI/NIAID NIH HHS/ -- P30AI042853/AI/NIAID NIH HHS/ -- R01 AI102907/AI/NIAID NIH HHS/ -- R01-AI076353/AI/NIAID NIH HHS/ -- R01-AI102907/AI/NIAID NIH HHS/ -- R01-AI52059/AI/NIAID NIH HHS/ -- T32-DA013911/DA/NIDA NIH HHS/ -- Intramural NIH HHS/ -- New York, N.Y. -- Science. 2014 May 23;344(6186):871-7. doi: 10.1126/science.1254417.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for International Health Research, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA. ; Division of Infectious Diseases, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA. ; Center for International Health Research, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA. Department of Pediatrics, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA. ; Department of Pathology and Laboratory Medicine, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, RI 02906, USA. ; Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20892, USA. ; Fred Hutchinson Cancer Research Center Program in Biostatistics and Biomathematics, Department of Biostatistics and Global Health, University of Washington, Seattle, WA 98109, USA. ; Center for International Health Research, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA. Department of Pathology and Laboratory Medicine, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, RI 02906, USA. jonathan_kurtis@brown.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24855263" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Animals ; Antibodies, Protozoan/blood/*immunology ; Antigens, Protozoan/*immunology ; Child ; Erythrocytes/*parasitology ; Hepatocytes/immunology/parasitology ; Humans ; Immunoglobulin G/blood/immunology ; Kenya ; Malaria/prevention & control ; Malaria Vaccines/*immunology ; Malaria, Falciparum/*prevention & control ; Mice ; Plasmodium berghei/immunology ; Plasmodium falciparum/*growth & development/immunology ; Protozoan Proteins/*immunology ; Recombinant Proteins/immunology ; Schizonts/*growth & development ; Young Adult
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Exploring the influence of vent location and eruption style on tephra fall hazard from the Okataina Volcanic Centre, New Zealand (2015)
    Springer Berlin Heidelberg
    Details
    Publication Date: 2021-06-25
    Description: Uncertainties in modelling volcanic hazards are often amplified in geographically large systems and in volcanoes which have a diverse eruption history that comprises variable eruption compositions and styles from different vent locations. The large ~ 700 km2 Okataina Volcanic Centre (OVC) is a large silicic caldera complex in a geodynamic region of New Zealand which has displayed a range of eruption styles and compositions over its current phase of activity (26 ka - present), including one basaltic maar-forming eruption, one basaltic Plinian eruption, and nine rhyolitic Plinian eruptions. All three of these eruption styles have occurred within the past 3.5 ky, and any of these styles could occur in the event of a future eruption. The location of a future eruption is also unknown. Future vents could potentially open in one of three different possible areas of the OVC: the Tarawera linear vent zone (LVZ) (5 eruptions over the past 26 ky), the Haroharo LVZ (5 eruptions over the past 26 ky), or outside of these LVZs (1 eruption over the past 26 ky). A future rhyolitic or basaltic Plinian eruption from the OVC is likely to generate widespread tephra fall in loads that will cause significant disruption and socio- economic impacts throughout the surrounding region. Past OVC tephra studies have focused on evaluating hazard from a rhyolitic Plinian eruption at select vent locations in the OVC's Tarawera LVZ. Here, we expand upon these past studies by evaluating tephra hazard for all possible OVC eruption vent areas and for both rhyolitic and basaltic Plinian eruption styles, and exploring how these parameters influence tephra hazard forecasts. Probabilistic volcanic hazard model BET_VH and advection-diffusion tephra hazard model TEPHRA2 were used to assess the hazard of accumulating ≥ 10 kg m-2 of tephra from both basaltic Plinian and rhyolitic Plinian eruption styles, occurring from within the Tarawera LVZ, the Haroharo LVZ, and other potential vent areas within the caldera. We present the results of these analyses as a first-order tephra hazard assessment for the entire OVC. Our results highlight the importance of considering all the potential vent locations of a volcanic system, in order to capture the full eruption catalogue in analyses (e.g., 11 eruptions over 26 ky for the OVC, versus only 5 eruptions over 26 ky for the Tarawera LVZ), as well as the full potential distribution of tephra hazard. Although the Tarawera LVZ has been prominently discussed in studies of OVC hazard because of is recent activity (1886 and ~1315 AD), we find that, in the event of future eruption, the likelihood of a vent opening within the Haroharo LVZ (last eruption 5.6 ka) is equivalent (〈 1% difference) to that for the Tarawera LVZ (31.8% compared to 32.5%). We also find that an eruption from within the Haroharo LVZ presents a relatively higher hazard to several localities, such as the town of Kawerau, where the average absolute probability of accumulating ≥ 10 kg m-2 of tephra is 1.3 times greater than for an eruption from within the Tarawera LVZ. While the absolute probabilities of accumulating ≥ 10 kg m-2 of tephra in the next one year from a basaltic Plinian eruption are on average 7.2 times lower than for a rhyolitic Plinian eruption throughout the surrounding region, our results suggest that the hazard posed by a basaltic Plinian eruption does contribute to the overall OVC tephra hazard, raising absolute probabilities for the entire OVC by an order of 0.14, which may have implications when considering sensitive decision-making thresholds.
    Description: Published
    Description: 38
    Description: 3V. Dinamiche e scenari eruttivi
    Description: JCR Journal
    Description: restricted
    Keywords: PVHA ; Okataina Volcanic Centre ; BET_VH ; TEPHRA2 ; volcanic hazard ; 04. Solid Earth::04.08. Volcanology::04.08.08. Volcanic risk
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 3
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    Towards real-time eruption forecasting in the Auckland Volcanic Field: application of BET_EF during the New Zealand National Disaster Exercise ‘Ruaumoko’ (2010)
    Details
    Publication Date: 2021-06-25
    Description: The Auckland Volcanic Field (AVF) is a young basaltic field that lies beneath the urban area of Auckland, New Zealand’s largest city. Over the past 250,000 years the AVF has produced at least 49 basaltic centers; the last eruption was only 600 years ago. In recognition of the high risk associated with a possible future eruption in Auckland, the New Zealand government ran Exercise Ruaumoko in March 2008, a test of New Zealand’s nation-wide preparedness for responding to a major disaster resulting from a volcanic eruption in Auckland City. The exercise scenario was developed in secret, and covered the period of precursory activity up until the eruption. During Exercise Ruaumoko we adapted a recently developed statistical code for eruption forecasting, namely BET_EF (Bayesian Event Tree for Eruption Forecasting), to independently track the unrest evolution and to forecast the most likely onset time, location and style of the initial phase of the simulated eruption. The code was set up before the start of the exercise by entering reliable information on the past history of the AVF as well as the monitoring signals expected in the event of magmatic unrest and an impending eruption. The average probabilities calculated by BET_EF during Exercise Ruaumoko corresponded well to the probabilities subjectively (and independently) estimated by the advising scientists (differences of few percentage units), and provided a sound forecast of the timing (before the event, the eruption probability reached 90%) and location of the eruption. This application of BET_EF to a volcanic field that has experienced no historical activity and for which otherwise limited prior information is available shows its versatility and potential usefulness as a tool to aid decision-making for a wide range of volcano types. Our near real-time application of BET_EF during Exercise Ruaumoko highlighted its potential to clarify and possibly optimize decision-making procedures in a future AVF eruption crisis, and as a rational starting point for discussions in a scientific advisory group. It also stimulated valuable scientific discussion around how a future AVF eruption might progress, and highlighted areas of future volcanological research that would reduce epistemic uncertainties through the development of better input models.
    Description: Published
    Description: 185–204
    Description: 4.3. TTC - Scenari di pericolosità vulcanica
    Description: JCR Journal
    Description: reserved
    Keywords: Auckland Volcanic Field ; Eruption forecasting ; Bayesian Event Tree ; Ruaumoko ; Disaster exercise ; 04. Solid Earth::04.08. Volcanology::04.08.08. Volcanic risk
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 4
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    Combining long- and short-term probabilistic volcanic hazard assessment with cost-benefit analysis to support decision making in a volcanic crisis from the Auckland Volcanic Field, New Zealand (2011)
    Springer Berlin Heidelberg
    Details
    Publication Date: 2021-06-25
    Description: By using BET_VH, we propose a quantitative probabilistic hazard assessment for base surge impact in Auckland, New Zealand. Base surges resulting from phreatomagmatic eruptions are among the most dangerous phenomena likely to be associated with the initial phase of a future eruption in the Auckland Volcanic Field. The assessment is done both in the long-term and in a specific short-term case study, i.e. the simulated pre-eruptive unrest episode during Exercise Ruaumoko, a national civil defence exercise. The most important factors to account for are the uncertainties in the vent location (expected for a volcanic field) and in the run-out distance of base surges. Here, we propose a statistical model of base surge run-out distance based on deposits from past eruptions in Auckland and in analogous volcanoes. We then combine our hazard assessment with an analysis of the costs and benefits of evacuating people (on a 1km x 1km cell grid). In addition to stressing the practical importance of a cost-benefit analysis in creating a bridge between volcanologists and decision makers, our study highlights some important points. First, in the Exercise Ruaumoko application, the evacuation call seems to be required as soon as the unrest phase is clear; additionally, the evacuation area is much larger than what is recommended in the current Contingency Plan. Secondly, the evacuation area changes in size with time, due to a reduction in the uncertainty in the vent location and increase in the probability of eruption. It is the tradeoff between these two factors that dictates which cells must be evacuated, and when, thus determining the ultimate size and shape of the area to be evacuated.
    Description: Published
    Description: 705-723
    Description: 4.3. TTC - Scenari di pericolosità vulcanica
    Description: JCR Journal
    Description: reserved
    Keywords: Auckland Volcanic Field ; Base surge ; Bayesian event tree ; Volcanic hazard ; Cost benefit analysis ; 04. Solid Earth::04.08. Volcanology::04.08.08. Volcanic risk
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 5
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    Towards real-time eruption forecasting in the Auckland Volcanic Field: application of BET_EF during the New Zealand National Disaster Exercise ‘Ruaumoko’ (2010)
    Details
    Publication Date: 2017-04-04
    Description: The Auckland Volcanic Field (AVF) is a young basaltic field that lies beneath the urban area of Auckland, New Zealand’s largest city. Over the past 250,000 years the AVF has produced at least 49 basaltic centers; the last eruption was only 600 years ago. In recognition of the high risk associated with a possible future eruption in Auckland, the New Zealand government ran Exercise Ruaumoko in March 2008, a test of New Zealand’s nation-wide preparedness for responding to a major disaster resulting from a volcanic eruption in Auckland City. The exercise scenario was developed in secret, and covered the period of precursory activity up until the eruption. During Exercise Ruaumoko we adapted a recently developed statistical code for eruption forecasting, namely BET_EF (Bayesian Event Tree for Eruption Forecasting), to independently track the unrest evolution and to forecast the most likely onset time, location and style of the initial phase of the simulated eruption. The code was set up before the start of the exercise by entering reliable information on the past history of the AVF as well as the monitoring signals expected in the event of magmatic unrest and an impending eruption. The average probabilities calculated by BET_EF during Exercise Ruaumoko corresponded well to the probabilities subjectively (and independently) estimated by the advising scientists (differences of few percentage units), and provided a sound forecast of the timing (before the event, the eruption probability reached 90%) and location of the eruption. This application of BET_EF to a volcanic field that has experienced no historical activity and for which otherwise limited prior information is available shows its versatility and potential usefulness as a tool to aid decision-making for a wide range of volcano types. Our near real-time application of BET_EF during Exercise Ruaumoko highlighted its potential to clarify and possibly optimize decision-making procedures in a future AVF eruption crisis, and as a rational starting point for discussions in a scientific advisory group. It also stimulated valuable scientific discussion around how a future AVF eruption might progress, and highlighted areas of future volcanological research that would reduce epistemic uncertainties through the development of better input models.
    Description: In press
    Description: 4.3. TTC - Scenari di pericolosità vulcanica
    Description: JCR Journal
    Description: reserved
    Keywords: Auckland Volcanic Field ; Eruption forecasting ; Bayesian Event Tree ; Ruaumoko ; Disaster exercise ; 04. Solid Earth::04.08. Volcanology::04.08.08. Volcanic risk
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 6
    Electronic Resource
    Electronic Resource
    Laser photolysis of HNO3 at 222 nm: Direct determination of the primary quantum yield of OH (1986)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 84 (1986), S. 6662-6667 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: A method has been developed and used in the direct determination of the primary quantum yield of OH in the laser photolysis of nitric acid at 222 nm. The amount of laser light absorbed was determined with a calibrated disk calorimeter. The amount of OH produced was determined by absorption spectroscopy using the resonance line at 308.3 nm and a published value of its line strength. The primary quantum yield of OH at 296 K was found to be 0.89±0.08 (95% confidence interval) with an uncertainty of +17%, −8% due to potential systematic errors. Within the experimental uncertainty, this result is consistent with a previous determination of a quantum yield of unity for the other product of photolysis, NO2.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.450719
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  • 7
    Electronic Resource
    Electronic Resource
    Isolation of the sodium 589.0-nm line by a voigt effect filter
    Amsterdam : Elsevier
    Analytica Chimica Acta 116 (1980), S. 365-374 
    Details
    ISSN: 0003-2670
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0003-2670(01)95217-1
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  • 8
    Electronic Resource
    Electronic Resource
    A sub-micron BiCMOS technology for telecommunications
    Amsterdam : Elsevier
    Microelectronic Engineering 15 (1991), S. 513-516 
    Details
    ISSN: 0167-9317
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Electrical Engineering, Measurement and Control Technology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-9317(91)90273-G
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  • 9
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    Organic−Inorganic Hybrid Membranes: Solving the Trade-off Phenomenon Between Permeation Flux and Selectivity in Pervaporation (2009)
    American Chemical Society
    Details
    Publication Date: 2009-04-15
    Print ISSN: 0888-5885
    Electronic ISSN: 1520-5045
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Published by American Chemical Society
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  • 10
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    Excimer lasers in cardiovascular surgery: Ablation products and photoacoustic spectrum of the arterial wall (1986)
    American Institute of Physics
    Details
    Publication Date: 1986-03-31
    Print ISSN: 0003-6951
    Electronic ISSN: 1077-3118
    Topics: Physics
    Published by American Institute of Physics
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