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  • 1
    Publication Date: 2012-12-20
    Description: The ~3240 Ma Panorama volcanic-hosted massive sulfide (VHMS) district is unusual for its high degree of exposure and low degree of postdepositional modification. In addition to typical seafloor VHMS deposits, this district contains greisen- and vein-hosted Mo-Cu-Zn-Sn mineral occurrences that are contemporaneous with VHMS orebodies and are hosted by the Strelley granite complex, which also drove VHMS circulation. Hence the Panorama district is a natural laboratory to investigate the role of magmatic-hydrothermal fluids in VHMS hydrothermal systems. Regional and proximal high-temperature alteration zones in volcanic rocks underlying the VHMS deposits are dominated by chlorite-quartz ± albite assemblages, with lesser low-temperature sericite-quartz ± K-feldspar assemblages. These assemblages are typical of VHMS hydrothermal systems. In contrast, the alteration assemblages associated with granite-hosted greisens and veins include quartz-topaz-muscovite-fluorite and quartz-muscovite (sericite)-chlorite-ankerite. These vein systems generally do not extend into the overlying volcanic pile. Fluid inclusion and stable isotope studies suggest that the greisens were produced by high-temperature (~590°C), high-salinity (38–56 wt % NaCl equiv) fluids with high densities (〉1.3 g/cm 3 ) and high 18 O (9.3 ± 0.6 ). These fluids are compatible with the measured characteristics of magmatic fluids evolved from the Strelley granite complex. In contrast, fluids in the volcanic pile (including the VHMS ore-forming fluids) were of lower temperature (90°–270°C), lower salinity (5.0–11.2 wt % NaCl equiv), with lower densities (0.88–1.01 g/cm 3 ) and lower 18 O (–0.8 ± 2.6 ). These fluids are compatible with evolved Paleoarchean seawater. Fluids that formed the quartz-chalcopyrite-sphalerite-cassiterite veins, which are present within the granite complex near the contact with the volcanic pile, were intermediate in temperature and isotopic composition between the greisen and volcanic pile fluids (T = 240°–315°C; 18 O = 4.3 ± 1.5 ) and are interpreted to indicate mixing between the two end-member fluids. Evidence of mixing between evolved seawater and magmatic-hydrothermal fluid within the granite complex, together with the lack of evidence for a magmatic component in fluids from the volcanic pile, suggest partitioning of magmatic-hydrothermal from evolved seawater hydrothermal systems in the Panorama VHMS system. This separation is interpreted to result from either the swamping of a relatively small magmatic-hydro-thermal system by evolved seawater or density contrasts precluding movement of magmatic-hydrothermal fluids into the volcanic pile. Variability in the salinity of fluids in the volcanic pile, combined with evidence for mixing of low- and high-salinity fluids in the massive sulfide lens, is interpreted to indicate that phase separation occurred within the Panorama hydrothermal system. Although we consider this phase separation to have most likely occurred at depth within the system, as has been documented in modern VHMS systems, the data do not allow the location of the inferred phase separation to be determined.
    Print ISSN: 0361-0128
    Topics: Geosciences
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  • 2
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1999-11-13
    Description: The factors required for the generation of memory CD4 T cells remain unclear, and whether there is a continuing requirement for antigen stimulation is critical to design of vaccine strategies. CD4 effectors generated in vitro from naive CD4 T cells of mice efficiently gave rise to small resting memory cells after transfer to class II-deficient hosts, indicating no requirement for further antigen or class II recognition.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Swain, S L -- Hu, H -- Huston, G -- New York, N.Y. -- Science. 1999 Nov 12;286(5443):1381-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Biomedical Research Laboratories, Trudeau Institute, 100 Algonquin Avenue, Saranac Lake, NY 12983, USA. sswain@northnet.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10558997" target="_blank"〉PubMed〈/a〉
    Keywords: Adoptive Transfer ; Animals ; Cell Division ; Cytokines/biosynthesis ; Histocompatibility Antigens Class II/*immunology ; Immunization ; *Immunologic Memory ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Receptors, Antigen, T-Cell/immunology ; T-Lymphocyte Subsets/cytology/*immunology ; Th1 Cells/cytology/*immunology ; Th2 Cells/cytology/*immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
    Publication Date: 2017-05-12
    Description: Multiple human diseases ensue from a hereditary or acquired deficiency of iron-transporting protein function that diminishes transmembrane iron flux in distinct sites and directions. Because other iron-transport proteins remain active, labile iron gradients build up across the corresponding protein-deficient membranes. Here we report that a small-molecule natural product, hinokitiol, can harness such gradients to restore iron transport into, within, and/or out of cells. The same compound promotes gut iron absorption in DMT1-deficient rats and ferroportin-deficient mice, as well as hemoglobinization in DMT1- and mitoferrin-deficient zebrafish. These findings illuminate a general mechanistic framework for small molecule–mediated site- and direction-selective restoration of iron transport. They also suggest that small molecules that partially mimic the function of missing protein transporters of iron, and possibly other ions, may have potential in treating human diseases.
    Keywords: Biochemistry
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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