Publication Date:
2006-08-05
Description:
We present a safe and convenient cross-coupling strategy for the large-scale synthesis of biaryls, commercially important structures often found in biologically active molecules. In contrast to traditional cross-couplings, which require the prior preparation of organometallic reagents, we use a copper catalyst to generate the carbon nucleophiles in situ, via decarboxylation of easily accessible arylcarboxylic acid salts. The scope and potential economic impact of the reaction are demonstrated by the synthesis of 26 biaryls, one of which is an intermediate in the large-scale production of the agricultural fungicide Boscalid.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goossen, Lukas J -- Deng, Guojun -- Levy, Laura M -- New York, N.Y. -- Science. 2006 Aug 4;313(5787):662-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut fur Organische Chemie, Technische Universitat Kaiserslautern, Erwin-Schrodinger-Strasse, Building 54, D-67663 Kaiserslautern, Germany. goossen@chemie.uni-kl.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16888137" target="_blank"〉PubMed〈/a〉
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink