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  • 1
    Electronic Resource
    Electronic Resource
    Effect of heterogeneity on the lag time in one-dimensional diffusion (1988)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 89 (1988), S. 2278-2280 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: A new general equation has been developed for the lag time for a dilute diffusant permeating through a one-dimensional membrane in which both diffusivity D and partition coefficient K are dependent on position. The lag time is given by tL=∫h0K(x)[∫x0 R(y)dy][∫hxR(y)dy] ×dx/ ∫h0R(x)dx, where h is the membrane thickness and R(x)=1/[D(x)K(x)]. Formulas derived from this equation include those for: lag time in the presence of an electrical potential gradient; lag time in a multilaminar periodic membrane; and an upper bound for lag time given by tL 〈(h2/ 4Deff), where Deff is the effective diffusivity as deduced from steady-state partitioning and permeability measurements. The lag time is shown to be independent of the direction of diffusion. A computational technique is presented in which the equation for tL is rearranged to a system of two differential equations, which are readily solvable by numerical integration, even when the system has discontinuities in D and K which would increase the difficulty of evaluating the double integral directly.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.455070
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  • 2
    Electronic Resource
    Electronic Resource
    Public Opinion: Sense Vs. Sensibility (1987)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 5 (1987), S. 14-14 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] On Halloween, the U.S. Congress Office of Technology Assessment (OTA), in collaboration with the polling outfit of Louis Harris and Associates, began sampling public attitudes about biotechnology. The effort is part of a major OTA study, due later this year and intended to give Congress a better ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0187-14
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  • 3
    Electronic Resource
    Electronic Resource
    This Workshop Works (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 871-871 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] What starts off Japanese, emerges half-Canadian, promises to become Latino, and resides in Baltimore? Nova Scotia sushi with summer salsa on a soft roll? An international thriller in which Yokohama detectives join force with Mounties to ferret out South American drug smugglers operating out of the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0989-871
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  • 4
    Electronic Resource
    Electronic Resource
    Democrats prioritize pricing, generics and drug safety (2007)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 25 (2007), S. 150-151 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] With Democrats reclaiming majorities in both the House of Representatives and Senate as of last November, the changing political dynamics in Washington present the biotech industry with “new and significant challenges and, hopefully, some new opportunities,” says Jim Greenwood, ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0207-150
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  • 5
    Electronic Resource
    Electronic Resource
    Conflicting signals on US accelerated approvals (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 1027-1028 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Since London-based AstraZeneca disclosed results last December from a phase 3 study showing its cancer drug Iressa (gefitinib) did not produce a significant survival advantage over placebo, it's become the poster child for companies with accelerated approval whiplash.... In June, the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0905-1027
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  • 6
    Electronic Resource
    Electronic Resource
    BIO reaches adolescence (2006)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 381-383 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] With the appointment in January 2005 of former US Representative James Greenwood, a Pennsylvania Republican, as its president, the Biotechnology Industry Organization (BIO) in Washington, DC, charted a new course, installing a cadre of Washington insiders in key staff positions (Box 1). After 15 ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0406-381
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  • 7
    Electronic Resource
    Electronic Resource
    The business of developing antibacterials (2006)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 1521-1528 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] For developers of antibacterial products, this century began very much on the wrong foot. The number of pharmaceutical companies chasing antibiotics continued to drop, few genuinely new antibiotics reached the clinic and investors remained lukewarm toward startups in this sector. But, despite ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt1206-1521
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  • 8
    Electronic Resource
    Electronic Resource
    Lawsuits anticipated on generic biologicals front (2003)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 21 (2003), S. 721-722 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Late in April, the Biotechnology Industry Organization (BIO; Washington, DC, USA) submitted a citizen's petition to the US Food and Drug Administration (FDA; Rockville, MD, USA), requesting an open public discussion of agency policy regarding “follow-on” biologics—that is, ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0703-721
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  • 9
    Electronic Resource
    Electronic Resource
    NAS issues mixed message on unintended effects of GM food (2004)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 22 (2004), S. 1062-1062 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] A report released on July 28 by a 13-member committee of the Institute of Medicine within the National Academy of Sciences (NAS) in Washington, DC, proposes to extend voluntary testing to all new foods that have been modified, regardless of the technique used to create the modification. Although ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0904-1062
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  • 10
    Electronic Resource
    Electronic Resource
    Biotech consulting, investing by NIH scientists curbed (2005)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 23 (2005), S. 274-274 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] National Institutes of Health (NIH) director Elias Zerhouni announced sweeping reforms early in February that will halt consulting arrangements by NIH scientists and severely restrict investments by them in biotechnology and other companies developing and making therapeutic and diagnostic products. ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0305-274
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