Publication Date:
2008-05-10
Description:
In the bacterium Escherichia coli, the Min proteins oscillate between the cell poles to select the cell center as division site. This dynamic pattern has been proposed to arise by self-organization of these proteins, and several models have suggested a reaction-diffusion type mechanism. Here, we found that the Min proteins spontaneously formed planar surface waves on a flat membrane in vitro. The formation and maintenance of these patterns, which extended for hundreds of micrometers, required adenosine 5'-triphosphate (ATP), and they persisted for hours. We present a reaction-diffusion model of the MinD and MinE dynamics that accounts for our experimental observations and also captures the in vivo oscillations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Loose, Martin -- Fischer-Friedrich, Elisabeth -- Ries, Jonas -- Kruse, Karsten -- Schwille, Petra -- New York, N.Y. -- Science. 2008 May 9;320(5877):789-92. doi: 10.1126/science.1154413.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Biotechnologisches Zentrum der Technischen Universitat Dresden, Tatzberg 47-51, 01307 Dresden, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18467587" target="_blank"〉PubMed〈/a〉
Keywords:
Adenosine Triphosphatases/*physiology
;
Adenosine Triphosphate/physiology
;
Bacterial Proteins
;
Cell Cycle Proteins/*physiology
;
Cell Division/*physiology
;
Cell-Free System
;
Cytoskeletal Proteins
;
Diffusion
;
Escherichia coli/*physiology
;
Escherichia coli Proteins/*physiology
;
Models, Biological
;
Oscillometry
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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