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  • 1
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    Atomic structure of adenosine deaminase complexed with a transition-state analog: understanding catalysis and immunodeficiency mutations (1991)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1991-05-31
    Description: The crystal structure of a murine adenosine deaminase complexed with 6-hydroxyl-1,6-dihydropurine ribonucleoside, a nearly ideal transition-state analog, has been determined and refined at 2.4 angstrom resolution. The structure is folded as an eight-stranded parallel alpha/beta barrel with a deep pocket at the beta-barrel COOH-terminal end wherein the inhibitor and a zinc are bound and completely sequestered. The presence of the zinc cofactor and the precise structure of the bound analog were not previously known. The 6R isomer of the analog is very tightly held in place by the coordination of the 6-hydroxyl to the zinc and the formation of nine hydrogen bonds. On the basis of the structure of the complex a stereoselective addition-elimination or SN2 mechanism of the enzyme is proposed with the zinc atom and the Glu and Asp residues playing key roles. A molecular explanation of a hereditary disease caused by several point mutations of an enzyme is also presented.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wilson, D K -- Rudolph, F B -- Quiocho, F A -- CA14030/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1991 May 31;252(5010):1278-84.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1925539" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Deaminase/*chemistry/deficiency/metabolism ; Amino Acid Sequence ; Animals ; Binding Sites ; Catalysis ; Crystallization ; Immunologic Deficiency Syndromes/*enzymology/genetics ; Mice ; Models, Molecular ; Molecular Structure ; Mutation ; Protein Conformation ; Purine Nucleosides/chemistry/*metabolism ; Ribonucleosides/chemistry/*metabolism ; Zinc/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
    Electronic Resource
    Electronic Resource
    Diffusion in a multicomponent inhomogeneous system with moving boundaries. I. Swelling at constant volume (1979)
    New York : Wiley-Blackwell
    Journal of Polymer Science: Polymer Physics Edition 17 (1979), S. 1709-1718 
    Details
    ISSN: 0098-1273
    Keywords: Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: A medium B contains a substance C which can diffuse. This mixture of B and C is brought into contact with a medium A which itself can diffuse into B. Now C diffuses through a swollen layer of A and B into A. The present study examines mathematically this process which, among other things, could serve as a model for migration in a system consisting of plastic packaging (polymer plus an additive) and the contents of the package. It is assumed that medium A (contents) with a constant diffusion coefficient diffuses into medium B (plastics) and that the diffusion of substance C (additive) in the pure B and into A can also be described by constant diffusion coefficients. The diffusion coefficient of substance C in the zone of mixed A and B is taken to be dependent on the concentration of A in B. Partition coefficients are assumed to exist at all interfaces between the media. The general equations of this coupled diffusion process are solved explicitly. The solutions are discussed and illustrated by several special cases. Furthermore, the total amount of C in A is calculated as a function of the diffusion coefficients of the partition coefficients of time, and of the concentration of A in B.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1979.180171007
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Diffusion in a multicomponent inhomogeneous multiphase system with moving boundaries. II. Increasing or decreasing volume (swelling or drying) (1980)
    New York : Wiley-Blackwell
    Journal of Polymer Science: Polymer Physics Edition 18 (1980), S. 2323-2336 
    Details
    ISSN: 0098-1273
    Keywords: Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The mathematical solution of the following problem is given. Simultaneously with diffusion-controlled mixing of two phases (e.g., gel formation), a third substance diffuses from one of the two pure phases into the other and through the inhomogeneous mixing phase which expands at a rate proportional to the square root of the time. The phases may change their volumes.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1980.180181202
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    Paper (German National Licenses)
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  • 4
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    Production of isoamyl acetate in ackA-pta and/or ldh mutants of Escherichia coli with overexpression of yeast ATF2 (2004)
    Springer
    Details
    Publication Date: 2004-02-01
    Print ISSN: 0175-7598
    Electronic ISSN: 1432-0614
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Published by Springer
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