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  • 1
    Publication Date: 2018
    Description: 〈p〉To explore the developmental reorganization of the three-dimensional genome of the brain in the context of neuropsychiatric disease, we monitored chromosomal conformations in differentiating neural progenitor cells. Neuronal and glial differentiation was associated with widespread developmental remodeling of the chromosomal contact map and included interactions anchored in common variant sequences that confer heritable risk for schizophrenia. We describe cell type–specific chromosomal connectomes composed of schizophrenia risk variants and their distal targets, which altogether show enrichment for genes that regulate neuronal connectivity and chromatin remodeling, and evidence for coordinated transcriptional regulation and proteomic interaction of the participating genes. Developmentally regulated chromosomal conformation changes at schizophrenia-relevant sequences disproportionally occurred in neurons, highlighting the existence of cell type–specific disease risk vulnerabilities in spatial genome organization.〈/p〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
    Publication Date: 2016-08-21
    Description: Pickup ion detection at Titan is challenging because ion cyclotron waves are rarely detected in the vicinity of the moon. In this work, signatures left by freshly produced pick up heavy ions ( m / q ∼ 16 to m / q ∼ 28) as detected in the plasma data by the CAPS/IMS instrument on-board Cassini are analyzed. In order to discern whether these correspond to ions of exospheric origin, one of the flybys during which the reported signatures were observed is investigated in detail. For this purpose, ion composition data from time of flight measurements and test particle simulations to constrain the ions' origin are used. After being validated, the detection method is applied to all the flybys for which the CAPS/IMS instrument gathered valid data, constraining the region around the moon where the signatures are observed. The results reveal an escape region located in the anti-Saturn direction as expected from the nominal corotation electric field direction. These findings provide new constraints for the area of freshly produced pickup ion escape, giving an approximate escape rate of .
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 3
    Publication Date: 2016-06-08
    Description: For most Cassini passes through the inner magnetosphere of Saturn, the hot-electron population (〉 few hundred eV) largely disappears inside of some cut-off L-shell. Anode-and-actuation-angle averages of hot-electron fluxes observed by the Cassini Electron Spectrometer (ELS) are binned into 0.1-R s bins in dipole L to explore the properties of this cutoff distance. The cut-off L-shell is quite variable from pass to pass (on time scales as short as 10-20 h). At energies of 5797 eV, 2054 eV, and 728 eV, 90% of the inner boundary values lie between L ~ 4.7 and 8.4, with a median near L = 6.2, consistent with the range of L values over which discrete interchange injections have been observed, thus strengthening the case that the interchange process is responsible for delivering the bulk of the hot electrons seen in the inner magnetosphere. The occurrence distribution of the inner boundary is more sharply peaked on the night side than at other local times. There is no apparent dependence of the depth of penetration on large-scale solar wind properties. It appears likely that internal processes (magnetic stress on mass-loaded flux tubes) are dominating the injection of hot electrons into the inner magnetosphere.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 4
    Publication Date: 2011-02-24
    Description: Earlier studies of Saturn's inner ionic radiation belts revealed that their content was surprisingly constant while their evolution appeared decoupled from dynamics of the Saturnian magnetosphere. Saturn's icy moons in combination with the neutral gas and dust that surround the planet seem to effectively restrict radial transport of energetic ions and are responsible for all these unusual characteristics. A possible process through which MeV ions may be populating the regions between the icy moons is cosmic ray albedo neutron decay (CRAND). While some circumstantial evidence suggests that this process actually occurs, the concept of CRAND has only been applied to the proton energy spectrum above ∼10 MeV; the source of ions below 10 MeV is not yet obvious. Additional hints about the nature of this source are now becoming evident by monitoring Saturn's radiation belts about half a solar cycle (from the declining phase of the solar maximum to solar minimum). Using Cassini's magnetosphere imaging instrument and low-energy magnetospheric measurement system (MIMI/LEMMS) data from June 2004 to June 2010, we detect a weak intensification of the trapped proton component that probably originates from CRAND (〉10 MeV). This anticipated enhancement, due to the solar cycle modulation of the galactic cosmic ray influx at Saturn, is closely followed by ions in the 1–10 MeV range. This observation sets constraints on the nature of those ions' source: this source should be connected (directly or indirectly) to the access of galactic cosmic rays in the Saturnian system. We also find evidence indicating that the ionic belts experience short-term variability following the occurrence of solar energetic particle events at Saturn's distance, probably associated with coronal mass ejections that propagate in the heliosphere. LEMMS data contain clear evidence of Earth-like Forbush decreases following such events. These decreases may explain the lack of an (expected) ionic belt intensification between 2004 and 2006.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 5
    Publication Date: 2013-02-05
    Description: [1]  We report on the evolution of auroral structures based on two 3-hour sequences of Saturn's northern hemisphere obtained with the UVIS instrument on board Cassini and we discuss their possible association with injections in the magnetosphere of Saturn.Simultaneously with the UV auroral structures we observe Energetic Neutral Atom (ENA) enhancements which are indicative of a rotating heated plasma region possibly related to magnetospheric injections. We examine the possibility that the UV auroral structures reported here are triggered by energetic particle injections by investigating a) the evolution of the longitudinal extent of an injection and b) its energy density, properties that change with time due to dispersion and ion/electron losses. We simulate the auroral counterpart of an injection considering that the precipitating energy flux could be provided to the ionosphere by pitch angle diffusion and electron scattering by whistler-mode waves. We compare the brightness and size evolution ofthe simulated ionospheric signature with the observed values and we demonstrate that the UV auroral structure behaves as an auroral signature of an injection. This comparative study defines characteristics of the injections such as the spectral index and the electron energy range as well as the magnetospheric corotation rate. Additionally, based on the simultaneous ENA-UV emissions we discuss the possibility that pitch angle diffusion and electron scattering may not be the only mechanism responsible for the observed auroral emissions. Field aligned currents driven by the pressure gradients along the boundaries of the injected hot plasma cloud could be also considered to play a role on how injections create auroral emissions at Saturn.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 6
    Publication Date: 2015-09-29
    Description: We report observations of auroral spirals at Saturn propagating from midnight to noon via dawn, based on Cassini/UVIS measurements. The aurora during that sequence is observed for the first time to consist of detached features swirling as they propagate from dawn to early afternoon. The features have a diameter of ∼6000 km in the ionosphere, which would correspond to 12 to 15 R S -wide plasma regions in the magnetosphere. Simultaneous ENA enhancements are observed, however, they do not show a clear spiral form. We estimate the velocity of the UV auroral features to decrease from 85% of rigid corotation (28°/h) near the equatorward edge to 68% of rigid corotation (22°/h) in the poleward edge. We discuss two posible scenarios which could explain the generation of the auroral spirals. Firstly, we suggest that the auroral spirals could be related to large dynamic hot populations which create regions with strong velocity gradients. Alternatively, a less possible theory could be that the auroral spirals are related to field line deformation from the magnetosphere to the ionosphere, similar to the scenario proposed to explain auroral spirals at Earth. Such field line twist can happen for a configuration where the magnetospheric source region is located between a pair of plasma flow vortices.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 7
    Publication Date: 2015-09-29
    Description: Radiation belts of MeV protons have been observed just outward of Saturn's main rings. During the final stages of the mission, the Cassini spacecraft will pass through the gap between the main rings and the planet. Based on how the known radiation belts of Saturn are formed, it is expected that MeV protons will be present in this gap and also bounce through the tenuous D-ring right outside the gap. At least one model has suggested that the intensity of MeV protons near the planet could be much larger than in the known belts. We model this inner radiation belt using a technique developed earlier to understand Saturn's known radiation belts. We find that the inner belt is very different from the outer belts in the sense that its intensity is limited by the densities of the D-ring and Saturn's upper atmosphere, not by radial diffusion and satellite absorption. The atmospheric density is relatively well constrained by EUV occultations. Based on that we predict an intensity in the gap region that is well below that of the known belts. It is more difficult to do the same for the region magnetically connected to the D-ring since its density is poorly constrained. We find that the intensity in this region can be comparable to the known belts. Such intensities pose no hazard to the mission since Cassini would only experience these fluxes on timescales of minutes, but might affect scientific measurements by decreasing the signal-to-contamination ratio of instruments.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 8
    Publication Date: 2016-02-03
    Description: The magnetospheric cusps are important sites of the coupling of a magnetosphere with the solar wind. The combination of both ground- and space-based observations at Earth have enabled considerable progress to be made in understanding the terrestrial cusp and its role in the coupling of the magnetosphere to the solar wind via the polar magnetosphere. Voyager 2 fully explored Neptune's cusp in 1989 but highly inclined orbits of the Cassini spacecraft at Saturn present the most recent opportunity to repeatedly studying the polar magnetosphere of a rapidly rotating planet. In this paper we discuss observations made by Cassini during two passes through Saturn's southern polar magnetosphere. Our main findings are that i) Cassini directly encounters the southern polar cusp with evidence for the entry of magnetosheath plasma into the cusp via magnetopause reconnection, ii) magnetopause reconnection and entry of plasma into the cusp can occur over a range of solar wind conditions, and iii) double cusp morphologies are consistent with the position of the cusp oscillating in phase with Saturn's global magnetospheric periodicities.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 9
    Publication Date: 2012-09-12
    Description: Observations of the radial locations of satellite absorption microsignatures in energetic particle data at Saturn have suggested the existence of an average convection pattern, fixed in local time, that is superimposed on the dominant near-corotation of the inner magnetosphere. Such a pattern should have additional observational consequences, and we use several different Cassini data sets to test these expectations. These include day/night asymmetries in the A-ring absorption signature of high-energy particles and total electron density, day/night asymmetries in plasma ion and electron temperatures, and day/night asymmetries in energetic-particle phase-space densities. For L 〉 4, the observations are found to be consistent with expectations based on the suggested convective drifts in a global noon-to-midnight electric field, such that particles drift outward on the dawn side of the magnetosphere and inward on the dusk side, resulting in drift orbits with an outward offset toward noon. The different data sets yield similar estimates of the required radial offsets, ∼0.5–1 Rs in the region inside L = 10. The corresponding convection electric field appears to decrease with increasing radial distance, from ∼0.3 mV/m near Tethys to ∼0.1 mV/m beyond Dione. The source of such an electric field remains a puzzle, but whatever the source, it appears to be a dominant factor in the circulation of plasma in Saturn's inner magnetosphere. For L 〈 4, the observations are not fully consistent with such a global convection field, and other explanations for A-ring absorption asymmetries are needed.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 10
    Publication Date: 2011-05-27
    Description: Saturn's magnetosphere has been studied extensively by the Cassini spacecraft during the last 6 years. We present mission-averaged energetic proton and electron measurements obtained by the MIMI/LEMMS instrument onboard Cassini in an energy range from several 10 keV to several 10 MeV separated by equatorial pitch angle. We discuss the resulting radial profiles and energy spectra. The measured intensities are converted to phase space densities. The distribution of energetic particles is governed by a large variety of processes. For instance, moons absorb energetic particles, creating macrosignatures or microsignatures. We have found that the moon Rhea is partly responsible for a change in gradient of electron phase space densities. We show that, in contrast to larger distances, the particle distribution for L 〈 8 is not driven by radial diffusion alone. There, the particle profiles are significantly modified due to Saturn's Neutral Torus, plasma environment, E ring, injection events, and cosmic ray albedo neutron decay. Large parts of our analysis are focused near L = 7. There, protons are lost within the Neutral Torus and not the E ring. For electrons, we find that these two losses are of comparable rate but have discovered that neither process is the dominant driver of loss. We point out that intensity measured by a energy channel, such as in a particle instrument, can actually increase in the region of ring and torus instead of decrease. The importance of injection events is shown to be at least of similar importance as radial diffusion.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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