Publication Date:
2016-05-12
Description:
Article SHANK3 mutations have been linked to autism spectrum disorders, although the underlying mechanisms remain unclear. Here, the authors generate a complete knockout Shank3 mouse model, identifying ASD-like behaviours associated with impaired mGluR5-Homer scaffolding and abnormal brain connectivity. Nature Communications doi: 10.1038/ncomms11459 Authors: Xiaoming Wang, Alexandra L. Bey, Brittany M. Katz, Alexandra Badea, Namsoo Kim, Lisa K. David, Lara J. Duffney, Sunil Kumar, Stephen D. Mague, Samuel W. Hulbert, Nisha Dutta, Volodya Hayrapetyan, Chunxiu Yu, Erin Gaidis, Shengli Zhao, Jin-Dong Ding, Qiong Xu, Leeyup Chung, Ramona M. Rodriguiz, Fan Wang, Richard J. Weinberg, William C. Wetsel, Kafui Dzirasa, Henry Yin, Yong-hui Jiang
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
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Natural Sciences in General
,
Physics
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