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  • 1
    Electronic Resource
    Electronic Resource
    Elimination of Macrophages Infiltrating into the Central Nervous System Suppresses Experimental Allergic Encephalomyelitis in Lewis Rats (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 594 (1990), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1990.tb40527.x
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  • 2
    Electronic Resource
    Electronic Resource
    Low-dose Cyclosporin A Induces Relapsing Experimental Allergic Encephalomyelitis in the Lewis Rat (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 540 (1988), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1988.tb27168.x
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  • 3
    Electronic Resource
    Electronic Resource
    The ontogenetic development of the follicular dendritic cell (1984)
    Springer
    Cell & tissue research 236 (1984), S. 203-206 
    Details
    ISSN: 1432-0878
    Keywords: Follicular dendritic cell ; Ontogeny ; Immunecomplex trapping ; Spleen (rat) ; Reticulum cell
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary After intravenous injection of horseradish peroxidase (HRP)-anti-HRP complexes in 21-day-old rats, complex trapping occurs on reticulum cells, forming the stroma of primary follicles of spleens. After intravenous injection of the same complexes in young adult rats (48 days old), trapping occurs on characteristic follicular dendritic cells (FDCs) located in well-developed germinal centers. These results strongly suggest that the follicular dendritic cell originates from a reticulum cell.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00216532
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  • 4
    Electronic Resource
    Electronic Resource
    Glycosyl receptors in macrophage subpopulations of rat spleen and lymph node (1990)
    Springer
    Cell & tissue research 262 (1990), S. 35-40 
    Details
    ISSN: 1432-0878
    Keywords: Spleen ; Lymph node ; Macrophage subpopulations ; Neoglycoproteins ; Glycosyl receptor ; Immunohistochemistry ; Rat (Wistar)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary We have developed an immunohistochemical method for the in vivo and in vitro detection of glycosyl receptors in rat spleen and lymph nodes by using neoglycoproteins. The receptor in both organs recognized mannose coupled to bovine serum albumin (mannose-BSA), fuscose-BSA, N-acetylglucosamine-BSA and to a lesser extent glucose-BSA, but not galactose-BSA or N-acetylgalactosamine-BSA. In vitro neoglycoprotein-receptor binding was Ca2+ dependent and could be inhibited by mannan but not by mannose. Simultaneous staining with the monoclonal antibodies ED1, ED2 or ED3 revealed that only ED1-and ED3-positive macrophages were involved in the binding of neoglycoproteins. In the spleen, the marginal-zone macrophages and a subpopulation of the marginal metallophils possess glycosylbinding receptors. In the lymph nodes, the medullary sinus macrophages and a subpopulation of the outercortex macrophages are able to bind neoglycoproteins.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00327742
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  • 5
    Electronic Resource
    Electronic Resource
    The role of macrophage subpopulations in autoimmune disease of the central nervous system (1996)
    Springer
    Journal of molecular histology 28 (1996), S. 83-97 
    Details
    ISSN: 1573-6865
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary In this review the role of various subpopulations of macrophages in the pathogenesis of experimental autoimmune encephalomyetitis is discussed. Immunohistochemistry with macrophage markers shows that in this disease different populations of macrophages (i.e. perivascular cells, microglia and infiltrating blood-borne macrophages) are present in the central nervous system. These subpopulations partially overlap in some functional activity while other activities seem to be restricted to a distinct subpopulation, indicating that these subpopulations have different roles in the pathogenesis of encephalomyelitis. The studies discussed in this review reveal that immunocytochemical and morphological studies, combined with new techniques such asin situ nick translation and experimental approaches like the use of bone marrow chimeras and macrophage depletion techniques, give valuable information about the types and functions of cells involved in central nervous system inflammation. The review is divided in three parts. In the first part the experimental autoimmune encephalomyelitis model is introduced. The second part gives an overview of the origin, morphology and functions of the various subpopulations. In the third part the role of these subpopulations is discussed in relation to the various stages (i.e. preclinical, clinical and recovery) of the experimental disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02331413
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  • 6
    Electronic Resource
    Electronic Resource
    Ontogenetic development of T- and B-lymphocytes and non-lymphoid cells in the white pulp of the rat spleen (1983)
    Springer
    Cell & tissue research 229 (1983), S. 351-363 
    Details
    ISSN: 1432-0878
    Keywords: Rat spleen ; Ontogeny ; Immunoperoxidase technique ; T- and B-lymphocytes ; Non-lymphoid cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The location and temporal appearance of the different classes of lymphocytes were investigated in the developing white pulp of the rat spleen. Additionally, indications were sought for the involvement of non-lymphoid cells in the localization of lymphocytes. The lymphocytes were demonstrated by their surface determinants (W3/13, IgM, IgG, IgA, Ia) in a two-step immunoperoxidase method; the non-lymphoid cells were characterized by immuno-enzyme-histochemical techniques. The results showed that 1) already at birth strongly Ia-positive cells are present in the T-cell area; 2) the marginal zone develops as a distinct compartment, independent of the PALS and follicles; 3) follicles are recognizable at day 14, the capacity to trap immune complexes on follicular dendritic cells occurring one week later. A possible relation between the development of the follicles and the differentiation of the follicular dendritic cell is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00214978
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  • 7
    Electronic Resource
    Electronic Resource
    Localization of horseradish peroxidase (HRP)-anti-HRP complexes in cryostat sections: Influence of endotoxin on trapping of immune complexes in the spleen of the rat (1983)
    Springer
    Cell & tissue research 232 (1983), S. 1-7 
    Details
    ISSN: 1432-0878
    Keywords: Immune complex trapping ; Spleen rat ; Endotoxin ; Follicle ; Follicular dendritic cell
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Cryostat sections of the rat spleen were incubated with a medium containing horseradish peroxidase (HRP)-anti-HRP complexes. After this incubation HRP-anti-HRP complexes were demonstrated in the follicle centres in the splenic white pulp. The localization pattern of the HRP-anti-HRP complexes after incubation (“in-vitro trapping”) was compared with the localization pattern of 125I BSA-anti-BSA complexes after intravenous injection (“in-vivo trapping”). Furthermore, the influence of endotoxin on the “in-vitro trapping” was studied. The “in-vitro trapping” was representative of the second, retaining phase of the “in-vivo trapping”. Evidence is presented that endotoxin inhibits trapping of immune complexes by a direct effect on the follicular dendritic cell.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00222369
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  • 8
    Electronic Resource
    Electronic Resource
    Regeneration of splenic tissue after autologous subcutaneous implantation: Homing of T- and B- and Ia-positive cells in the white pulp of the rat spleen (1983)
    Springer
    Cell & tissue research 229 (1983), S. 97-107 
    Details
    ISSN: 1432-0878
    Keywords: Splenic implants ; Immunoperoxidase technique ; Lymphocyte homing ; Interdigitating cells ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The localization of T-and B lymphocytes and interdigitating cells (IDC) was investigated during the regeneration process of splenic implants. For this purpose a two-step immunoperoxidase technique was used to visualize T-cell antigen, immunoglobulins and Ia-antigen on cryostat sections. The specific localization of the repopulating lymphocytes occurred simultaneously with the development of non-lymphoid elements characteristic for the different compartments of the white pulp, i.e., the periarteriolar lymphocyte sheaths (PALS) and follicles. The marginal zone (MZ) developed after the PALS and primary follicles, but before germinal center reactions were found. During ontogeny, however, the development of a broad MZ precedes the formation of follicles. This difference in sequence of events is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00217883
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  • 9
    Electronic Resource
    Electronic Resource
    Ontogenetic aspects of immune-complex trapping in the spleen and popliteal lymph nodes of the rat (1982)
    Springer
    Cell & tissue research 223 (1982), S. 545-552 
    Details
    ISSN: 1432-0878
    Keywords: Immune complex trapping ; Ontogeny ; Follicular dendritic cell ; Immunoperoxidase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary An ontogenetic approach was used to obtain information about the relation between structure and function of lymphoid tissues. In particular the development of the capacity to trap immune complexes was studied in relation to the development of the lymphoid compartments. For this purpose isologous horseradish (HRP)-anti-HRP complexes were injected into neonatal rats, and their fate was studied in the spleen and popliteal lymph nodes. Immune-complex trapping occurred as soon as primary follicles could be recognized; without follicles no trapping was observed. Several explanations for this simultaneous development of trapping capacity and follicular structure are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00218475
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  • 10
    Electronic Resource
    Electronic Resource
    Regeneration of splenic tissue after autologous subcutaneous implantation: Development of non-lymphoid cells in the white pulp of the rat spleen (1982)
    Springer
    Cell & tissue research 222 (1982), S. 69-79 
    Details
    ISSN: 1432-0878
    Keywords: Splenic implants ; Non-lymphoid cells ; Trapping ; Enzyme histochemistry ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Regeneration of splenic tissue after autologous subcutaneous implantation provides a useful model for studying the development of splenic tissue. The development of the various non-lymphoid cells of the white pulp in the rat is described. It appears that regeneration of the implants is initiated by ingrowing vessels and a newly formed reticulum, which forms the microenvironment for the homing lymphocytes. Marginal metallophils are found at their characteristic location at the inner border of the marginal sinus five weeks after implantation. Trapping of antigen-antibody complexes reappears when the first primary follicles can be recognized.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00218289
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