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  • 1
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    A Prospective Phase II Study on Tandem Autografting-Nonmyeloablative Allografting for Newly Diagnosed Myeloma: Final Results of the Gruppo Italiano Trapianto Midollo Osseo. (2007)
    American Society of Hematology
    Details
    Publication Date: 2007-11-16
    Description: The development of nonmyeloablative conditionings has recently reduced the transplant-related mortality (TRM) and extended the eligible age for transplantation up to 65–70 years. From January 2000 to June 2005, 106 newly diagnosed patients younger than 65 years were enrolled in a prospective phase II study at 15 Italian Centers. Fifty-eight were also previously described in a comparison of autografting with allografting based on a genetic randomisation (Bruno et al. N Engl J Med 2007). Here we report on a larger GITMO experience with a longer follow-up. Induction chemotherapy consisted of VAD-based regimens, followed by a cytoreductive autograft with melphalan 200 mg/m2, and by a non-myeloablative 2 Gy TBI-based allograft from an HLA-identical sibling. Graft-vs-host disease (GVHD) prophylaxis included cyclosporin and mycophenolate mofetil. Primary endpoints were overall (OS) and event-free (EFS) survivals. Secondary endpoint was TRM. One-hundred-two (96%) patients, median age 54 (30–65), completed the tandem program whereas 4 withdrew their consent. After a median follow-up of 54 (21–94) months, OS was not reached and median EFS was 35 (31–56) months post-transplant. Incidences of acute grade II-IV GHVD and extensive chronic GVHD were 40% and 50% respectively. Fourteen (13%) patients died from TRM, 14 (13%) from disease progression, 2 from lung cancer (2%) and 1 from lymphoma (1%). Overall response, defined as complete (CR) and partial remission, was 91% (93/102), with 53 patients achieving CR. Overall 39/102 patients relapsed, however only 8/53 of those who reached CR post-transplant. By multivariate-analysis disease response prior to allografting was significantly associated with longer OS (HR 0.27, CI 0.09–0.80, p
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
    Topics: Biology , Medicine
    Published by American Society of Hematology
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  • 2
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    Background seismicity in the Central Apennines of Italy: The Abruzzo region case study (2007)
    Elsevier
    Details
    Publication Date: 2007-11-01
    Print ISSN: 0040-1951
    Electronic ISSN: 1879-3266
    Topics: Geosciences , Physics
    Published by Elsevier
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  • 3
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    Acute graft-versus-host disease: grade and outcome in patients with chronic myelogenous leukemia. Working Party Chronic Leukemia of the European Group for Blood and Marrow Transplantation (1995)
    American Society of Hematology
    Details
    Publication Date: 1995-07-15
    Description: Acute graft-versus-host disease (aGVHD) has been classified according to the Seattle criteria as grades 0, I, II, III, and IV for 20 years. The predictive value of such detailed grading is a matter of debate; publications usually report GVHD as present or absent or as absent, moderate, or severe. The Working Party Chronic Leukemia of the European Group for Bone Marrow Transplantation analyzed data of 1,294 patients transplanted from an allogeneic donor for chronic myelogenous leukemia (CML) in first chronic phase and tested the predictive value of aGVHD grading for the following end-points: day 100 mortality (D100M), transplant-related mortality (TRM), relapse incidence (RI), leukemia- free survival (LFS), and survival (SURV). aGVHD was absent in 462 patients (35.7%), grade I occurred in 335 (25.8%), grade II in 264 (20.5%), grade III in 110 (8.5%), and grade IV in 123 patients (9.5%). A total of 297 patients (23%) died within 100 days, 495 patients (38%) died of any TRM, and 100 patients (8%) died of relapse. D100M according to grades 0, I, II, III, and IV was 17%, 13%, 19%, 38%, and 70%, respectively, with significant difference between 0-II versus III-IV. TRM was 28%, 27%, 43%, 68%, and 92%, respectively, with a distinct separation between 0-I versus II-IV. RI showed a continuous decrease of 37%, 30%, 23%, 18%, and 8%, respectively, with increasing aGVHD. LFS was 45%, 51%, 44%, 26%, and 7%, respectively, and was best for patients with grade I aGVHD. This finding was also reflected in a better overall survival (60%, 64%, 53%, 30%, and 8%, respectively). The better LFS for grade I aGVHD patients compared with patients with grade 0 or II aGVHD was confirmed (P = .05) in a multivariate analysis. These data document the value of the present 5-point grading of aGVHD, ie, different outcome is observed depending on endpoint analyzed. Restricting information about aGVHD to presence or absence is not warranted.
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
    Topics: Biology , Medicine
    Published by American Society of Hematology
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  • 4
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    Seismic Monitoring in Northeastern Italy: A Ten-year Experience (2005)
    Seismological Society of America
    Details
    Publication Date: 2005-07-01
    Print ISSN: 0895-0695
    Electronic ISSN: 1938-2057
    Topics: Geosciences
    Published by Seismological Society of America
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  • 5
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    OGS improvements in the year 2011 in running the Northeastern Italy Seismic Network (2013)
    Copernicus
    Details
    Publication Date: 2013-04-30
    Description: The Centro di Ricerche Sismologiche (CRS, Seismological Research Center) of the Istituto Nazionale di Oceanografia e di Geofisica Sperimentale - OGS (Italian National Institute for Oceanography and Experimental Geophysics) in Udine (Italy) after the strong earthquake of magnitude Mw = 6.4 occurred in 1976 in the Italian Friuli-Venezia Giulia region, started to operate the Northeastern Italy Seismic Network: it currently consists of 12 very sensitive broad band and 21 simpler short period seismic stations, all telemetered to and acquired in real time at the OGS-CRS data centre in Udine. Real time data exchange agreements in place with other Italian, Slovenian, Austrian and Swiss seismological institutes lead to a total number of 93 seismic stations acquired in real time, which makes the OGS the reference institute for seismic monitoring of Northeastern Italy, as shown in Fig. 1 (Bragato et al., 2011; Saraò et al., 2010). Since 2002 OGS-CRS is using the Antelope software suite as the main tool for collecting, analyzing, archiving and exchanging seismic data, initially in the framework of the EU Interreg IIIA project "Trans-national seismological networks in the South-Eastern Alps" (Bragato et al., 2010; Pesaresi et al., 2008). SeisComP is also used as a real time data exchange server tool. In order to improve the seismological monitoring of the Northeastern Italy area, at OGS-CRS we tuned existing programs and created ad hoc ones like: a customized web server named PickServer to manually relocate earthquakes, a script for automatic moment tensor determination, scripts for web publishing of earthquake parametric data, waveforms, state of health parameters and shaking maps, noise characterization by means of automatic spectra analysis, and last but not least scripts for email/SMS/fax alerting. A new OGS-CRS real time seismological website (http://rts.crs.inogs.it/) has also been operative since several years.
    Print ISSN: 1680-7340
    Electronic ISSN: 1680-7359
    Topics: Geosciences
    Published by Copernicus on behalf of European Geosciences Union.
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  • 6
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    Mainshocks and aftershocks of the 2002 molise seismic sequence, southern Italy (2007)
    Springer
    Details
    Publication Date: 2017-04-04
    Description: In October and November 2002, the Molise region (southern Italy) was struck by two moderate magnitude earth- quakeswithin 24 hours followed by an onemonth long aftershocks sequence. Soon after the ?rstmainshock (October 31st, 10.32 UTC, Mw 5.7), we deployed a temporary network of 35 three-component seismic stations. At the time of occurrence of the second main event (November 1st, 15.08 UTC, Mw 5.7) the eight local stations already installed allowed us to well constrain the hypocentral parameters. We present the location of the two mainshocks and 1929 aftershocks with 2 〈 ML 〈 4.2. Earthquake distribution reveals a E-trending 15 km long fault system composed by two main segments ruptured by the two mainshocks. Aftershocks de?ne two sub-vertical dextral strike-slip fault segments in agreementwith themainshock fault plane solutions. P- and T -axes retrieved from170 aftershocks focal mechanisms show a coherent kinematics: with a sub-horizontal NW and NE-trending P and T -axes, respectively. Fora small percentage of focal mechanisms (~10%) a rotation of T axes is observed, resulting in thrust solutions. The Apenninic active normal fault belt is located about 80 km westward of the 2002 epicentral area and signi?cant seismicity occurs only 20-50 km to the east, in the Gargano promontory. Seismic hazard was thought to be small for this region because neither historical earthquake are reported in the Italian seismic catalogue or active faults were previously identi?ed. In this context, the 2002 seismic sequence highlights the existence of trans-pressional active tectonics in between the extensional Apenninic belt and the Apulian foreland.
    Description: Published
    Description: 487-494
    Description: 1.1. TTC - Monitoraggio sismico del territorio nazionale
    Description: JCR Journal
    Description: reserved
    Keywords: Molise seismic sequence ; strike slip fault system ; 04. Solid Earth::04.07. Tectonophysics::04.07.07. Tectonics
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 7
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    Background seismicity in the Central Apennines of Italy: The Abruzzo region case study (2007)
    Elsevier
    Details
    Publication Date: 2017-04-04
    Description: We investigate background seismic activity of the Abruzzo region, a 5000 km2 area located within the Central Apennines of Italy, where in the past 600 years at least 5 large earthquakes (I=XI – X) have occurred. Between April 2003 and September 2004, a dense temporary seismic network composed of 30 digital three-component seismic stations recorded 850 earthquakes with 0.9〈ML〈3.7. We present earthquake locations and focal mechanisms obtained by standard procedures and an optimized velocity model computed with a search technique based on genetic algorithms. The seismicity occurs at a low and constant rate of ~2.6 e-04 events/day*km2 and is sparsely distributed within the first 15 km of the crust. Minor increases in the seismicity rate are related to the occurrence of small and localised seismic sequences that occur at the tip of major active normal faults along secondary structures. We observe that during the 16 months of study period, the Fucino fault system responsible for the 1915 Fucino earthquake (MS=7.0), and the major normal faults of the area, did not produce significant seismic activity. Fault plane solutions evaluated using P-wave polarity data show the predominance of normal faulting mechanisms (~55%) with NE-trending direction of extension coherent with the regional stress field active in this sector of the Apennines. Around 27% of the focal solutions have pure strike-slip mechanisms and the rest shows transtensional faulting mechanisms that mainly characterise the kinematics of the secondary structures activated by the small sequences. We hypothesize that the largest known NW-trending normal faults are presently locked and we propose that in the case of activation, the secondary structures located at their tips may act as transfer faults accommodating a minor part of the extensional deformation with strike-slip motion.
    Description: Published
    Description: 80-92
    Description: 3.1. Fisica dei terremoti
    Description: JCR Journal
    Description: reserved
    Keywords: background seismicity ; 04. Solid Earth::04.06. Seismology::04.06.01. Earthquake faults: properties and evolution
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 8
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    ACQUIRING SEISMIC DATA IN THE NORTH-EAST OF ITALY: THE OGS-CRS EXPERIENCE IN USING THE ANTELOPE SOFTWARE SUITE (2007)
    Details
    Publication Date: 2017-04-04
    Description: NO
    Description: Published
    Description: ecees 2006
    Description: open
    Keywords: NON ; 04. Solid Earth::04.06. Seismology::04.06.06. Surveys, measurements, and monitoring
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: Conference paper
    Format: 5294318 bytes
    Format: application/pdf
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  • 9
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    Data mining from Antelope at OGS-CRS (Udine, Italy) (2010)
    CTBTO
    Details
    Publication Date: 2017-04-04
    Description: Since 2002 the Seismological Research Centre (Centro di Ricerche Sismologiche, CRS, http://www.crs.inogs.it) of the National Institute for Oceanography and Experimental Geophysics (OGS) in Trieste (Italy) is involved in the EU INTERREG IIIA project “Trans-national seismological networks in the South-Eastern Alps” together with other four Institutions: Zentralanstalt für Meteorologie und Geodynamik (ZAMG) in Vienna (Austria), the Earth Science Department of the Trieste University in Trieste (Italy) and the Agencija Republike Slovenije Za Okolje (ARSO) in Ljubljana (Slovenia). The commercial Antelope software suite from BRTT has been chosen as the common basis for real time data exchange, rapid location of earthquakes and alerting. Antelope is a powerful software suite that easily allows sharing data in real time among neighbouring institutions. However it must be tuned to each seismological data centre needs in order to extract the specific information required. At OGS-CRS we adapted existing programs and created new ones like: a customized interface to manually relocate earthquakes, a script for automatic moment tensor determination, scripts for web publishing of earthquake locations, waveforms, state of health parameters and shaking maps, plus scripts for email/SMS/fax alerting.
    Description: Published
    Description: Vienna, Austria
    Description: 5.2. TTC - Banche dati di sismologia strumentale
    Description: open
    Keywords: data mining ; Antelope ; 05. General::05.02. Data dissemination::05.02.02. Seismological data
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: Conference paper
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  • 10
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    Acquiring, archiving, analyzing and exchanging seismic data in real time at the Seismological Research Center of the OGS in Italy (2012)
    Istituto Nazionale di Geofisica e Vulcanologia
    Details
    Publication Date: 2017-04-04
    Description: After the 1976 Friuli earthquake (Ms = 6.5) in north-eastern Italy that caused about 1,000 casualties and widespread destruction in the Friuli area, the Italian government established the Centro di Ricerche Sismologiche (CRS). This is now a department of the Istituto Nazionale di Oceanografia e di Geofisica Sperimentale (OGS), and it is specifically devoted to the monitoring of the seismicity of north-eastern Italy. Since its inception, the North-East Italy Seismic Network has grown enormously. Currently, it consists of 14 broad-band and 20 short-period seismic stations, all of which are telemetered to and acquired in real time at the OGS-CRS data center in Udine. Data exchange agreements in place with other Italian, Slovenian, Austrian and Swiss seismological institutes lead to a total number of 94 seismic stations acquired in real time, which confirms that the OGS is the reference institute for seismic monitoring of north-eastern Italy. Since 2002, CRS has been using the Antelope software suite as the main tool for collecting, analyzing, archiving and exchanging seismic data. SeisComP is also used as a real-time data exchange server tool. A customized web accessible server is used to manually relocate earthquakes, and automatic procedures have been set-up for moment-tensor determination, shaking-map computation, web publishing of earthquake parametric data, waveform drumplots, state-of-health parameters, and quality checks of the station by spectra analysis. Scripts for email/SMS/fax alerting to public institutions have also been customized. Recently, a real-time seismology website was designed and set-up (http://rts.crs.inogs.it/).
    Description: Istituto Nazionale di Geofisica e Vulcanologia
    Description: Published
    Description: 67-75
    Description: 1.1. TTC - Monitoraggio sismico del territorio nazionale
    Description: JCR Journal
    Description: open
    Keywords: Seismological Research Center ; OGS ; acquiring seismic data ; archiving seismic data ; analyzing seismic data ; exchanging seismic data ; real time ; 04. Solid Earth::04.06. Seismology::04.06.06. Surveys, measurements, and monitoring
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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