Publication Date:
2006-02-14
Description:
Mice experiencing repeated aggression develop a long-lasting aversion to social contact, which can be normalized by chronic, but not acute, administration of antidepressant. Using viral-mediated, mesolimbic dopamine pathway-specific knockdown of brain-derived neurotrophic factor (BDNF), we showed that BDNF is required for the development of this experience-dependent social aversion. Gene profiling in the nucleus accumbens indicates that local knockdown of BDNF obliterates most of the effects of repeated aggression on gene expression within this circuit, with similar effects being produced by chronic treatment with antidepressant. These results establish an essential role for BDNF in mediating long-term neural and behavioral plasticity in response to aversive social experiences.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Berton, Olivier -- McClung, Colleen A -- Dileone, Ralph J -- Krishnan, Vaishnav -- Renthal, William -- Russo, Scott J -- Graham, Danielle -- Tsankova, Nadia M -- Bolanos, Carlos A -- Rios, Maribel -- Monteggia, Lisa M -- Self, David W -- Nestler, Eric J -- New York, N.Y. -- Science. 2006 Feb 10;311(5762):864-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9070, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16469931" target="_blank"〉PubMed〈/a〉
Keywords:
Aggression
;
Animals
;
Antidepressive Agents/pharmacology
;
Brain-Derived Neurotrophic Factor/genetics/*physiology
;
Depression/physiopathology
;
Dominance-Subordination
;
Dopamine/*physiology
;
Fluoxetine/pharmacology
;
Gene Expression Profiling
;
Gene Expression Regulation/drug effects
;
Imipramine/pharmacology
;
Limbic System/*physiology
;
Male
;
Mice
;
Mice, Inbred C57BL
;
Neurons/physiology
;
Nucleus Accumbens/*physiology
;
Oligonucleotide Array Sequence Analysis
;
Proto-Oncogene Proteins c-fos/biosynthesis
;
*Social Behavior
;
Social Isolation
;
*Stress, Psychological
;
Ventral Tegmental Area/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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