Publication Date:
1997-04-11
Description:
Activation of CD4(+) T lymphocytes from human immunodeficiency virus-type 1 (HIV-1)-infected donors with immobilized antibodies to CD3 and CD28 induces a virus-resistant state. This effect is specific for macrophage-tropic HIV-1. Transcripts encoding CXCR4/Fusin, the fusion cofactor used by T cell line-tropic isolates, were abundant in CD3/CD28-stimulated cells, but transcripts encoding CCR5, the fusion cofactor used by macrophage-tropic viruses, were not detectable. Thus, CD3/CD28 costimulation induces an HIV-1-resistant phenotype similar to that seen in some highly exposed and HIV-uninfected individuals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carroll, R G -- Riley, J L -- Levine, B L -- Feng, Y -- Kaushal, S -- Ritchey, D W -- Bernstein, W -- Weislow, O S -- Brown, C R -- Berger, E A -- June, C H -- St Louis, D C -- New York, N.Y. -- Science. 1997 Apr 11;276(5310):273-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, MD 20850, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9092480" target="_blank"〉PubMed〈/a〉
Keywords:
Antibodies, Monoclonal/immunology
;
Antigens, CD28/*immunology
;
Antigens, CD3/immunology
;
CD4-Positive T-Lymphocytes/*immunology/metabolism/*virology
;
Cells, Cultured
;
Gene Expression Regulation
;
HIV-1/*physiology
;
Humans
;
Interleukin-2/immunology
;
*Lymphocyte Activation
;
Membrane Fusion
;
Membrane Proteins/*genetics
;
Muromonab-CD3/immunology
;
Phytohemagglutinins/pharmacology
;
RNA, Messenger/genetics/metabolism
;
Receptors, CCR5
;
Receptors, CXCR4
;
Receptors, Cytokine/genetics
;
Receptors, HIV/*genetics
;
Up-Regulation
;
Virus Replication
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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