Publication Date:
2015-06-13
Description:
Jan et al. (Research Articles, 7 November 2014, p. 716) propose that ribosomes translating secretome messenger RNAs (mRNAs) traffic from the cytosol to the endoplasmic reticulum (ER) upon emergence of the signal peptide and return to the cytosol after termination. An accounting of controls demonstrates that mRNAs initiate translation on ER-bound ribosomes and that ribosomes are retained on the ER through many cycles of translation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Reid, David W -- Nicchitta, Christopher V -- GM101533/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2015 Jun 12;348(6240):1217. doi: 10.1126/science.aaa7257. Epub 2015 Jun 11.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Program in Cardiovascular and Metabolic Disorders, Duke-NUS Graduate Medical School, Singapore 169857, Singapore. ; Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA. christopher.nicchitta@duke.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26068841" target="_blank"〉PubMed〈/a〉
Keywords:
Cells/*metabolism
;
Endoplasmic Reticulum/*metabolism
;
Humans
;
Mitochondria/*metabolism
;
*Protein Biosynthesis
;
Ribosomes/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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