Publication Date:
2001-04-09
Description:
The Drosophila melanogaster gene chico encodes an insulin receptor substrate that functions in an insulin/insulin-like growth factor (IGF) signaling pathway. In the nematode Caenorhabditis elegans, insulin/IGF signaling regulates adult longevity. We found that mutation of chico extends fruit fly median life-span by up to 48% in homozygotes and 36% in heterozygotes. Extension of life-span was not a result of impaired oogenesis in chico females, nor was it consistently correlated with increased stress resistance. The dwarf phenotype of chico homozygotes was also unnecessary for extension of life-span. The role of insulin/IGF signaling in regulating animal aging is therefore evolutionarily conserved.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Clancy, D J -- Gems, D -- Harshman, L G -- Oldham, S -- Stocker, H -- Hafen, E -- Leevers, S J -- Partridge, L -- New York, N.Y. -- Science. 2001 Apr 6;292(5514):104-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11292874" target="_blank"〉PubMed〈/a〉
Keywords:
Aging/*physiology
;
Alleles
;
Animals
;
Body Constitution
;
Carrier Proteins/genetics/metabolism
;
Crosses, Genetic
;
*Drosophila Proteins
;
Drosophila melanogaster/genetics/*physiology
;
Female
;
Fertility
;
Genes, Insect
;
Heterozygote
;
Hot Temperature
;
Insect Proteins/*genetics/*metabolism
;
Insulin/metabolism
;
Insulin Receptor Substrate Proteins
;
*Intracellular Signaling Peptides and Proteins
;
Longevity/*physiology
;
Male
;
Mutation
;
Oxidative Stress
;
Protein-Tyrosine Kinases/genetics/metabolism
;
*Receptor Protein-Tyrosine Kinases
;
Receptor, Insulin/*metabolism
;
Reproduction
;
Signal Transduction
;
Somatomedins/metabolism
;
Starvation
;
Superoxide Dismutase
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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