Publication Date:
1987-03-06
Description:
Ribonuclease mitochondrial RNA processing, a site-specific endoribonuclease involved in primer RNA metabolism in mammalian mitochondria, requires an RNA component for its activity. On the basis of copurification and selective inactivation with complementary oligonucleotides, a 135-nucleotide RNA species, not encoded in the mitochondrial genome, is identified as the RNA moiety of the endoribonuclease. This finding implies transport of a nucleus-encoded RNA, essential for organelle DNA replication, to the mitochondrial matrix.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chang, D D -- Clayton, D A -- GM-33088-16/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1987 Mar 6;235(4793):1178-84.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2434997" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Base Sequence
;
Cell Nucleus/*physiology
;
Chemical Phenomena
;
Chemistry
;
Drug Resistance
;
Endonucleases/isolation & purification/metabolism
;
Enzyme Activation/drug effects
;
*Genetic Code
;
Humans
;
Mammals/*genetics/metabolism
;
Micrococcal Nuclease/pharmacology
;
Mitochondria/*metabolism
;
Oligonucleotides/pharmacology
;
Organoids/physiology
;
RNA/*biosynthesis/genetics/isolation & purification/physiology
;
Ribonucleases/metabolism
;
Subcellular Fractions/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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