Publication Date:
1998-06-26
Description:
Transgenic plants expressing Bacillus thuringiensis (Bt) toxins are currently being deployed for insect control. In response to concerns about Bt resistance, we investigated a toxin secreted by a different bacterium Photorhabdus luminescens, which lives in the gut of entomophagous nematodes. In insects infected by the nematode, the bacteria are released into the insect hemocoel; the insect dies and the nematodes and bacteria replicate in the cadaver. The toxin consists of a series of four native complexes encoded by toxin complex loci tca, tcb, tcc, and tcd. Both tca and tcd encode complexes with high oral toxicity to Manduca sexta and therefore they represent potential alternatives to Bt for transgenic deployment.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bowen, D -- Rocheleau, T A -- Blackburn, M -- Andreev, O -- Golubeva, E -- Bhartia, R -- ffrench-Constant, R H -- New York, N.Y. -- Science. 1998 Jun 26;280(5372):2129-32.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Entomology, University of Wisconsin-Madison, Madison, WI 53706 USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9641921" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Animals
;
Bacterial Proteins/chemistry/genetics/isolation & purification/*toxicity
;
Cloning, Molecular
;
Endotoxins/chemistry/genetics/isolation & purification/*toxicity
;
*Enterobacteriaceae/chemistry/genetics
;
Gene Deletion
;
*Insecticides
;
Manduca
;
Molecular Sequence Data
;
Open Reading Frames
;
Pest Control, Biological
;
Sequence Homology, Amino Acid
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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