ISSN:
0030-4921
Keywords:
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Configurations and preferred conformations of a number of hexahydro[1,3]thiazolo[3,2-a]pyridines have been assigned on the basis of their 1H and 13C NMR spectra. The conformational preferences of these compounds have been interpreted in terms of the minimization of dipolar type interactions, arising from 1,3 arrangements of the heteroatoms, which are increased by the electron donor induction effect of the alkyl groups. The stereochemistry of the salts of these bases is very different from that of the free compounds. For the gem-disubstituted compound, an explanation in terms of the ‘gem-dimethyl effect’ and a slight deformation at the nitrogen atom is proposed.
Additional Material:
1 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/mrc.1270170206
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