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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Biochemistry 5 (1966), S. 467-477 
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of medicinal chemistry 38 (1995), S. 4125-4130 
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 57 (2001), S. 1071-1078 
    ISSN: 1399-0047
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: Leech anti-platelet protein (LAPP) from the leech Haementeria officinalis is a collagen-binding protein that inhibits the collagen-mediated adhesion of blood platelets. The crystal structure of recombinant LAPP has been determined using single isomorphous replacement with anomalous scattering combined with solvent flattening and threefold molecular averaging. The model of LAPP has been refined to 2.2 Å resolution (R factor 21.5%; free R factor 24.0%). LAPP contains an 89-residue C-terminal domain consisting of a central six-stranded antiparallel β-sheet flanked on one side by an α-helix and on the other side by two extended loops with little secondary structure. A 36-residue N-terminal region is not visible in the electron-density map. This region is rich in glycine and lacks hydrophobic residues. It probably does not have a compact globular fold, but instead has an extended conformation and is flexible. The crystal packing suggests that LAPP may form tightly interacting dimers. The fold of the C-terminal domain of LAPP closely resembles that of the N-domain of hepatocyte growth factor (HGF), which classifies LAPP as a PAN domain. However, no significant sequence homology exists between LAPP and other PAN domains. Common structural features between LAPP and the HGF N-domain include two disulfide bonds that link the α-helix to the central region of the protein and five residues with a conserved hydrophobic nature that are located in the core of the domain. These conserved structural features may be an important determinant of the PAN-domain type of fold.
    Type of Medium: Electronic Resource
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  • 4
    Publication Date: 2022-05-25
    Description: Author Posting. © American Geophysical Union, 2015. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research: Oceans 120 (2015): 608–633, doi:10.1002/2014JC010254.
    Description: The coastal waters of the northern portion of the California Current System experience a seasonal decline in oxygen concentrations and hypoxia over the summer upwelling season that results in negative impacts on habitat for many organisms. Using a regional model extending from 43°N to 50°N, with an oxygen component developed in this study, drivers of seasonal and regional oxygen variability are identified. The model includes two pools of detritus, which was an essential addition in order to achieve good agreement with the observations. The model was validated using an extensive array of hydrographic and moored observations. The model captures the observed seasonal decline as well as spatial trends in bottom oxygen. Spatially, three regions of high respiration are identified as locations where hypoxia develops each modeled year. Two of the regions are previously identified recirculation regions. The third region is off of the Washington coast. Sediment oxygen demand causes the region on the Washington coast to be susceptible to hypoxia and is correlated to the broad area of shallow shelf (〈60 m) in the region. Respiration and circulation-driven divergence contribute similar (60, 40%, respectively) amounts to the integrated oxygen budget on the Washington coast while respiration dominates the Oregon coast. Divergence, or circulation, contributes to the oxygen dynamics on the shelf in two ways: first, through the generation of retention features, and second, by determining variability.
    Description: This work was supported by a postdoctoral fellowship to Samantha Siedlecki from JISAO and the Program on Climate Change at the University of Washington, and grants from the Coastal Ocean Program of the National Oceanic and Atmospheric Administration (NOAA) (NA09NOS4780180) and the National Science Foundation (NSF) (OCE0942675) as part of the Pacific Northwest Toxins (PNWTOX) project.
    Description: 2015-08-05
    Keywords: Hypoxia ; Oxygen ; Respiration ; Upwelling
    Repository Name: Woods Hole Open Access Server
    Type: Article
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  • 5
    Publication Date: 2022-05-25
    Description: Author Posting. © American Geophysical Union, 2014. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research: Oceans 119 (2014): 6269–6285, doi:10.1002/2014JC010153.
    Description: The shallow depth of the inner continental shelf allows for rapid adjustment of the ocean to air-sea exchange of heat and momentum compared with offshore locations. Observations during 2001–2013 are used to evaluate the contributions of air-sea heat flux and oceanic advection to interannual variability of inner-shelf temperature in the Middle Atlantic Bight. Wintertime processes are important for interpreting regional interannual variability at nearshore locations since winter anomalies account for 69–77% of the variance of the annual anomalies and are correlated over broad along-shelf scales, from New England to North Carolina. At the Martha's Vineyard Coastal Observatory on the 12 m isobath, a heat budget is used to test the hypothesis that interannual differences in winter temperatures are due solely to air-sea heat flux. Bimonthly averages of air-sea heat flux are correlated with temporal changes in temperature, but overestimate the observed wintertime cooling. Velocity and satellite-derived temperature data show that interannual variability in wintertime surface cooling is partially compensated for by alongshore advection of warmer water from the west at this particular location. It is also shown that surface heat flux is a strong function of air-sea temperature difference. Because of this coupling between ocean and air temperatures in shallow water, along-shelf advection can significantly modify the surface heat flux at seasonal and interannual time scales. While along-shelf advection at relatively small (∼100 km) scales can be an important component of the heat budget over the inner shelf, interannual temperature variability is still largely determined by adjustment to large-scale air-temperature anomalies.
    Description: T. Connolly was supported by the Postdoctoral Scholar Program at the Woods Hole Oceanographic Institution, with funding provided by the United States Geological Survey. S. Lentz was funded by Ocean Sciences Division of the National Science Foundation, grants OCE-0548961 (SWWIM) and OCE-1332646 (ISLE).
    Description: 2015-03-17
    Keywords: Temperature ; Coastal ; Nearshore ; Inner shelf ; Heat budget ; Interannual
    Repository Name: Woods Hole Open Access Server
    Type: Article
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  • 6
    Publication Date: 2022-10-26
    Description: Author Posting. © American Geophysical Union, 2019. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research-Oceans 53(3), (2019): 1639-1649, doi:10.1029/2018JC014454.
    Description: Circulation patterns over the inner continental shelf can be spatially complex and highly variable in time. However, few studies have examined alongshore variability over short scales of kilometers or less. To observe inner‐shelf bottom temperatures with high (5‐m) horizontal resolution, a fiber‐optic distributed temperature sensing system was deployed along a 5‐km‐long portion of the 15‐m isobath within a larger‐scale mooring array south of Martha's Vineyard, MA. Over the span of 4 months, variability at a range of scales was observed along the cable over time periods of less than a day. Notably, rapid cooling events propagated down the cable away from a tidal mixing front, showing that propagating fronts on the inner shelf can be generated locally near shallow bathymetric features in addition to remote offshore locations. Propagation velocities of observed fronts were influenced by background tidal currents in the alongshore component and show a weak correlation with theoretical gravity current speeds in the cross‐shore component. These events provide a source of cold, dense water into the inner shelf. However, differences in the magnitude and frequency of cooling events at sites separated by a few kilometers in the alongshore direction suggest that the characteristics of small‐scale variability can vary dramatically and can result in differential fluxes of water, heat, and other tracers. Thus, under stratified conditions, prolonged subsurface observations with high spatial and temporal resolution are needed to characterize the implications of three‐dimensional circulation patterns on exchange, especially in regions where the coastline and isobaths are not straight.
    Description: Deployment of the DTS system was made possible by the Center for Transformative Environmental Monitoring Programs (CTEMPS), with input, assistance, and software provided by John Selker, Scott Tyler, Paul Wetzel, Mark Hausner, and Scott Kobs. The authors thank Hugh Popenoe, Jared Schwartz, and Brian Guest for their technical expertise and effort with setup, deployment, and recovery of the DTS system, as well as the captains and crew of the R/V Discovery and R/V Tioga. Janet Fredericks assisted with integrating the DTS measurements with Martha's Vineyard Coastal Observatory infrastructure. Steve Lentz was instrumental in the design and deployment of the ISLE mooring array. Craig Marquette provided invaluable expertise and effort in the deployment of the ISLE mooring array. The authors thank Greg Gerbi for providing velocity data at site H and Malcolm Scully for providing velocity and near‐bottom temperature data at site E. Kenneth Brink and two anonymous reviewers provided valuable comments on the manuscript. DTS measurements were supported by the Woods Hole Oceanographic Institution. The ISLE project is supported by NSF (OCE‐83264600). T. Connolly acknowledges support from NSF (OCE‐1433716) and a WHOI postdoctoral scholarship funded by the U.S. Geological Survey and the WHOI Coastal Ocean Institute. DTS data are available on Zenodo (Connolly & Kirincich, 2018, https://doi.org/10.5281/zenodo.1136113). ISLE mooring data are available on the WHOI Open Access Data Server (Kirincich & Lentz, 2017b, https://doi.org/10.1575/1912/8740).
    Description: 2019-06-28
    Keywords: Inner shelf ; Alongshore variability ; Fronts ; Distributed temperature sensing
    Repository Name: Woods Hole Open Access Server
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  • 7
    Publication Date: 2022-05-26
    Description: Author Posting. © American Meteorological Society, 2014. This article is posted here by permission of American Meteorological Society for personal use, not for redistribution. The definitive version was published in Journal of Physical Oceanography 44 (2014): 319–342, doi:10.1175/JPO-D-13-095.1.
    Description: The California Undercurrent (CUC), a poleward-flowing feature over the continental slope, is a key transport pathway along the west coast of North America and an important component of regional upwelling dynamics. This study examines the poleward undercurrent and alongshore pressure gradients in the northern California Current System (CCS), where local wind stress forcing is relatively weak. The dynamics of the undercurrent are compared in the primitive equation Navy Coastal Ocean Model and a linear coastal trapped wave model. Both models are validated using hydrographic data and current-meter observations in the core of the undercurrent in the northern CCS. In the linear model, variability in the predominantly equatorward wind stress along the U.S. West Coast produces episodic reversals to poleward flow over the northern CCS slope during summer. However, reproducing the persistence of the undercurrent during late summer requires additional incoming energy from sea level variability applied south of the region of the strongest wind forcing. The relative importance of the barotropic and baroclinic components of the modeled alongshore pressure gradient changes with latitude. In contrast to the southern and central portions of the CCS, the baroclinic component of the alongshore pressure gradient provides the primary poleward force at CUC depths over the northern CCS slope. At time scales from weeks to months, the alongshore pressure gradient force is primarily balanced by the Coriolis force associated with onshore flow.
    Description: This work was supported by grants to B. Hickey from the Coastal Ocean Program of the National Oceanic and Atmospheric Administration (NOAA) (NA17OP2789 and NA09NOS4780180) and the National Science Foundation (NSF) (OCE0234587 and OCE0942675) as part of the Ecology of Harmful Algal Blooms Pacific Northwest (ECOHAB PNW) and Pacific Northwest Toxin (PNWTOX) projects. I. Shulman was supported by the Naval Research Laboratory.
    Description: 2014-07-01
    Keywords: Geographic location/entity ; Continental shelf/slope ; Circulation/ Dynamics ; Baroclinic flows ; Coastal flows ; Models and modeling ; Model evaluation/performance ; Variability ; Intraseasonal variability ; Seasonal variability
    Repository Name: Woods Hole Open Access Server
    Type: Article
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  • 8
    Publication Date: 2022-05-26
    Description: Author Posting. © American Geophysical Union, 2014. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research: Oceans 119 (2014): 953-975, doi:10.1002/2013JC009452.
    Description: A numerical model of the northern California Current System along the coasts of Washington and British Columbia is used to quantify the impact of submarine canyons on upwelling from the continental slope onto the shelf. Comparisons with an extensive set of observations show that the model adequately represents the seasonal development of near-bottom density, as well as along-shelf currents that are critical in governing shelf-slope exchange. Additional model runs with simplified coastlines and bathymetry are used to isolate the effects of submarine canyons. Near submarine canyons, equatorward flow over the outer shelf is correlated with dense water at canyon heads and subsequent formation of closed cyclonic eddies, which are both associated with cross-shelf ageostrophic forces. Lagrangian particles tracked from the slope to midshelf show that canyons are associated with upwelling from depths of ∼140–260 m. Source depths for upwelling are shallower than 150 m at locations away from canyons and in a model run with bathymetry that is uniform in the along-shelf direction. Water upwelled through canyons is more likely to be found near the bottom over the shelf. Onshore fluxes of relatively saline water through submarine canyons are large enough to increase volume-averaged salinity over the shelf by 0.1–0.2 psu during the early part of the upwelling season. The nitrate input from the slope to the Washington shelf associated with canyons is estimated to be 30–60% of that upwelled to the euphotic zone by local wind-driven upwelling.
    Description: This work was part of T. Connolly’s graduate research at University of Washington and was supported by grants from the Coastal Ocean Program of the National Oceanic and Atmospheric Administration (NOAA) (NA17OP2789, NA09NOS4780180) and the National Science Foundation (NSF) (OCE0234587, OCE0942675) as part of the ECOHAB PNW and PNWTOX projects.
    Description: 2014-08-12
    Keywords: Submarine canyon ; California Current ; Coastal upwelling ; Shelf-slope exchange ; Numerical model ; Particle tracking
    Repository Name: Woods Hole Open Access Server
    Type: Article
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  • 9
    Publication Date: 2020-07-30
    Description: There is a strong policy move in Britain to improve forest resilience to climate change by increasing stand structural and species diversity. Although currently little used in Britain, the technique of underplanting allows regeneration and diversification of stands while avoiding some of the disadvantages of clearfelling. Two experiments were examined: (1) the growth and survival of five underplanted conifer species of differing shade tolerance in a shelterwood and (2) compared performance of underplanted and open-grown Douglas-fir seedlings on restocking sites. Underplanted Sitka spruce, Norway spruce, noble fir, European silver fir and Douglas-fir were all able to survive and grow. However increased exposure following overstorey removal resulted in some damage and ‘socketing’, especially to taller seedlings, particularly Douglas-fir. This may be linked to poor root development when growing under an overstorey. Microclimate conditions on some underplanted sites were more sheltered from extreme climatic conditions, and in some cases this improved survival of Douglas-fir seedlings. However, seedling growth rates were reduced compared with those on open sites probably due to lower light levels. Underplanting may help to improve establishment success of some species, particularly in exposed areas. However, the shelter benefits of underplanting must be carefully balanced against the trade-off with lower light, and underplanting is likely to be more successful where low canopy density is maintained.
    Print ISSN: 0015-752X
    Electronic ISSN: 1464-3626
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
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  • 10
    Publication Date: 1985-04-01
    Print ISSN: 0968-0004
    Electronic ISSN: 1362-4326
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Published by Cell Press
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