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  • 1
    Electronic Resource
    Electronic Resource
    A neural network model to determine the plate width set-up value in a hot plate mill (2000)
    Springer
    Journal of intelligent manufacturing 11 (2000), S. 547-557 
    Details
    ISSN: 1572-8145
    Keywords: Hot strip mill ; edger roll ; width spread ; neural network estimator
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract Performance of the process reducing the slab width in hot plate mill called edging is critical to produce rolled products with a desired dimension, which otherwise increase the yield loss caused by trimming. This process, therefore, requires a stringent width control performance. In this paper, an edger set-up model generating the desired slab width required for the control is proposed based upon the neural network approach. This neural network model accounts for variation of the dimension of incoming slabs to predict the preset value of the width as accurately as possible. A series of simulations were conducted to evaluate the performance of the neural network estimator for a variety of operating conditions needed for producing rolled products of various dimensions. The results show that the proposed model can estimate the preset value of the slab width with good accuracy, thereby enhancing the dimensional accuracy of rolled products. The estimation performance is discussed in detail for various process operation conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026552406200
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    Paper (German National Licenses)
    Fulltext
  • 2
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    Ferroelectricity Driven by Yd0-ness with Rehybridization inYMnO3 (2007)
    American Physical Society
    Details
    Publication Date: 2007-05-21
    Print ISSN: 0031-9007
    Electronic ISSN: 1079-7114
    Topics: Physics
    Published by American Physical Society
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  • 3
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    MEMCover: integrated analysis of mutual exclusivity and functional network reveals dysregulated pathways across multiple cancer types (2015)
    Oxford University Press
    Details
    Publication Date: 2015-06-14
    Description: Motivation: The data gathered by the Pan-Cancer initiative has created an unprecedented opportunity for illuminating common features across different cancer types. However, separating tissue-specific features from across cancer signatures has proven to be challenging. One of the often-observed properties of the mutational landscape of cancer is the mutual exclusivity of cancer driving mutations. Even though studies based on individual cancer types suggested that mutually exclusive pairs often share the same functional pathway, the relationship between across cancer mutual exclusivity and functional connectivity has not been previously investigated. Results: We introduce a classification of mutual exclusivity into three basic classes: within tissue type exclusivity, across tissue type exclusivity and between tissue type exclusivity. We then combined across-cancer mutual exclusivity with interactions data to uncover pan-cancer dysregulated pathways. Our new method, Mutual Exclusivity Module Cover (MEMCover) not only identified previously known Pan-Cancer dysregulated subnetworks but also novel subnetworks whose across cancer role has not been appreciated well before. In addition, we demonstrate the existence of mutual exclusivity hubs, putatively corresponding to cancer drivers with strong growth advantages. Finally, we show that while mutually exclusive pairs within or across cancer types are predominantly functionally interacting, the pairs in between cancer mutual exclusivity class are more often disconnected in functional networks. Contact: przytyck@ncbi.nlm.nih.gov Supplementary information: Supplementary data are available at Bioinformatics online.
    Print ISSN: 1367-4803
    Electronic ISSN: 1460-2059
    Topics: Biology , Computer Science , Medicine
    Published by Oxford University Press
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  • 4
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    Dissecting cancer heterogeneity with a probabilistic genotype-phenotype model (2013)
    Oxford University Press
    Details
    Publication Date: 2013-09-26
    Description: One of the obstacles hindering a better understanding of cancer is its heterogeneity. However, computational approaches to model cancer heterogeneity have lagged behind. To bridge this gap, we have developed a new probabilistic approach that models individual cancer cases as mixtures of subtypes. Our approach can be seen as a meta-model that summarizes the results of a large number of alternative models. It does not assume predefined subtypes nor does it assume that such subtypes have to be sharply defined. Instead given a measure of phenotypic similarity between patients and a list of potential explanatory features, such as mutations, copy number variation, microRNA levels, etc., it explains phenotypic similarities with the help of these features. We applied our approach to Glioblastoma Multiforme (GBM). The resulting model Prob_GBM, not only correctly inferred known relationships but also identified new properties underlining phenotypic similarities. The proposed probabilistic framework can be applied to model relations between similarity of gene expression and a broad spectrum of potential genetic causes.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
    Published by Oxford University Press
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  • 5
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    Van Allen Probes Observations of Electromagnetic Ion Cyclotron Waves Triggered by Enhanced Solar Wind Dynamic Pressure (2016)
    Wiley
    Details
    Publication Date: 2016-10-01
    Description: Magnetospheric compression due to impact of enhanced solar wind dynamic pressure P dyn has long been considered as one of the generation mechanisms of electromagnetic ion cyclotron (EMIC) waves. With the Van Allen Probe-A observations, we identify three EMIC wave events that are triggered by P dyn enhancements under prolonged northward IMF quiet time preconditions. They are in contrast to one another in a few aspects. Event 1 occurs in the middle of continuously increasing P dyn while Van Allen Probe-A is located outside the plasmapause at post-midnight and near the equator (magnetic latitude (MLAT) ~ -3 o ). Event 2 occurs by a sharp P dyn pulse impact while Van Allen Probe-A is located inside the plasmapause in the dawn sector and rather away from the equator (MLAT ~ 12 o ). Event 3 is characterized by amplification of a pre-existing EMIC wave by a sharp P dyn pulse impact while Van Allen Probe-A is located outside the plasmapause at noon and rather away from the equator (MLAT ~ -15 o ). These three events represent various situations where EMIC waves can be triggered by P dyn increases. Several common features are also found among the three events. (i) The strongest wave is found just above the He + gyrofrequency. (ii) The waves are nearly linearly polarized with a rather oblique propagation direction (~28 o to ~39 o on average). (iii) The proton fluxes increase in immediate response to the P dyn impact, most significantly in tens of keV energy, corresponding to the proton resonant energy. (iv) The temperature anisotropy with T ⊥  〉 T || is seen in the resonant energy for all the events, although its increase by the P dyn impact is not necessarily always significant. The last two points (iii) and (iv) may imply that, in addition to the temperature anisotropy, the increase of the resonant protons must have played a critical role in triggering the EMIC waves by the enhanced P dyn impact.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 6
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    Spatial Dependence of Electromagnetic Ion Cyclotron Waves Triggered by Solar Wind Dynamic Pressure Enhancements (2017)
    Wiley
    Details
    Publication Date: 2017-05-13
    Description: In this paper, using the multi-satellite (the Van Allen Probes and two GOES satellites) observations in the inner magnetosphere, we examine two EMIC wave events that are triggered by P dyn enhancements under prolonged northward IMF quiet time preconditions. For both events, the impact of enhanced P dyn causes EMIC waves at multiple points. However, we find a strong spatial dependence that EMIC waves due to enhanced P dyn impact can occur at multiple points (likely globally but not necessarily everywhere) but with different wave properties. For Event 1, three satellites situated at a nearly same dawn side zone but at slightly different L shells see occurrence of EMIC waves but in different frequencies relative to local ion gyrofrequencies and with different polarizations. These waves are found inside or at the outer edge of the plasmasphere. Another satellite near noon observes no dramatic EMIC wave despite the strongest magnetic compression there. For Event 2, the four satellites are situated at widely separated MLT zones when they see occurrence of EMIC waves. They are again found at different frequencies relative to local ion gyrofrequencies with different polarizations, and all outside the plasmasphere. We propose two possible explanations that (i) if triggered by enhanced P dyn impact, details of ion cyclotron instability growth can be sensitive to local plasma conditions related to background proton distributions, and (ii) there can be pre-existing waves with a specific spatial distribution, which determines occurrence and specific properties of EMIC waves depending on satellite's relative position after an enhanced P dyn arrives.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 7
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    Unique insight into GI absorption [Applied Biological Sciences] (2013)
    National Academy of Sciences
    Details
    Publication Date: 2013-08-21
    Description: Polymeric microspheres (MSs) have received attention for their potential to improve the delivery of drugs with poor oral bioavailability. Although MSs can be absorbed into the absorptive epithelium of the small intestine, little is known about the physiologic mechanisms that are responsible for their cellular trafficking. In these experiments, nonbiodegradable...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 8
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    Dosage-Dependent Expression Variation Suppressed on the Drosophila Male X Chromosome (2018)
    Genetics Society of America (GSA)
    Details
    Publication Date: 2018-02-09
    Description: DNA copy number variation is associated with many high phenotypic heterogeneity disorders. We systematically examined the impact of Drosophila melanogaster deletions on gene expression profiles to ask whether increased expression variability owing to reduced gene dose might underlie this phenotypic heterogeneity. Indeed, we found that one-dose genes have higher gene expression variability relative to two-dose genes. We then asked whether this increase in variability could be explained by intrinsic noise within cells due to stochastic biochemical events, or whether expression variability is due to extrinsic noise arising from more complex interactions. Our modeling showed that intrinsic gene expression noise averages at the organism level and thus cannot explain increased variation in one-dose gene expression. Interestingly, expression variability was related to the magnitude of expression compensation, suggesting that regulation, induced by gene dose reduction, is noisy. In a remarkable exception to this rule, the single X chromosome of males showed reduced expression variability, even compared with two-dose genes. Analysis of sex-transformed flies indicates that X expression variability is independent of the male differentiation program. Instead, we uncovered a correlation between occupancy of the chromatin-modifying protein encoded by males absent on the first ( mof ) and expression variability, linking noise suppression to the specialized X chromosome dosage compensation system. MOF occupancy on autosomes in both sexes also lowered transcriptional noise. Our results demonstrate that gene dose reduction can lead to heterogeneous responses, which are often noisy. This has implications for understanding gene network regulatory interactions and phenotypic heterogeneity. Additionally, chromatin modification appears to play a role in dampening transcriptional noise.
    Electronic ISSN: 2160-1836
    Topics: Biology
    Published by Genetics Society of America (GSA)
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  • 9
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    Shoot Organogenesis from Immature Zygotic Embryo Cultures of Ginkgo biloba (2003)
    Springer
    Details
    Publication Date: 2003-09-01
    Print ISSN: 0006-3134
    Electronic ISSN: 1573-8264
    Topics: Biology
    Published by Springer
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  • 10
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    Plant Regeneration from Immature Embryo Cultures of Vigna unguiculata (2003)
    Springer
    Details
    Publication Date: 2003-09-01
    Print ISSN: 0006-3134
    Electronic ISSN: 1573-8264
    Topics: Biology
    Published by Springer
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