Publication Date:
2016-11-29
Description:
Amplification of USP13 drives ovarian cancer metabolism Nature Communications, Published online: 28 November 2016; doi:10.1038/ncomms13525 Cancer cells need to reprogramme their metabolism to allow rapid cell proliferation. Here, the authors show that USP13 is amplified in ovarian cancer and its protein product, a deubiquitinase, drives tumour progression by rewiring the metabolism of cancer cells by stabilising two critical metabolic enzymes.
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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