ISSN:
1420-9071
Keywords:
Rat liver
;
liver, rat
;
heme metabolism
;
cytochrome
;
cyclophosphamide
;
δ-aminolaevulinate synthase
;
heme oxygenase
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary Im male rats hepatic cytochromes b5 and P-450 were reduced at different times after treatment with cyclophosphamide (CP) (200 mg/kg i.p. for 3 days). In contrast, microsomal heme did not change until 48 h after the last dose of CP, leading to accumulation of heme in a ‘non-cytochromal’ form. Parallel to the above changes the heme metabolism showed derangement: δ-aminolaevulinate synthase, the rate-limiting enzyme in heme synthesis, was depressed and heme oxygenase, the enzyme which catalyzes the oxidative degradation of heme, was increased.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01951905
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