Publication Date:
2014-04-26
Description:
Tissue-resident macrophages are heterogeneous as a consequence of anatomical niche-specific functions. Many populations self-renew independently of bone marrow in the adult, but the molecular mechanisms of this are poorly understood. We determined a transcriptional profile for the major self-renewing population of peritoneal macrophages in mice. These cells specifically expressed the transcription factor Gata6. Selective deficiency of Gata6 in myeloid cells caused substantial alterations in the transcriptome of peritoneal macrophages. Gata6 deficiency also resulted in dysregulated peritoneal macrophage proliferative renewal during homeostasis and in response to inflammation, which was associated with delays in the resolution of inflammation. Our investigations reveal that the tissue macrophage phenotype is under discrete tissue-selective transcriptional control and that this is fundamentally linked to the regulation of their proliferation renewal.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4185421/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4185421/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rosas, Marcela -- Davies, Luke C -- Giles, Peter J -- Liao, Chia-Te -- Kharfan, Bashar -- Stone, Timothy C -- O'Donnell, Valerie B -- Fraser, Donald J -- Jones, Simon A -- Taylor, Philip R -- 094143/Wellcome Trust/United Kingdom -- G0601617/Medical Research Council/United Kingdom -- MR/J002151/1/Medical Research Council/United Kingdom -- MR/K02003X/1/Medical Research Council/United Kingdom -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2014 May 9;344(6184):645-8. doi: 10.1126/science.1251414. Epub 2014 Apr 24.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cardiff Institute of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24762537" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
*Cell Proliferation
;
GATA6 Transcription Factor/genetics/*physiology
;
Inflammation/immunology
;
Macrophages, Peritoneal/*immunology
;
Mice
;
Mice, Knockout
;
Myeloid Cells/immunology
;
Phenotype
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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