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  • 1
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    Human brain structural and functional connectivity [Neuroscience] (2013)
    National Academy of Sciences
    Details
    Publication Date: 2013-04-10
    Description: Magnetic resonance imaging enables the noninvasive mapping of both anatomical white matter connectivity and dynamic patterns of neural activity in the human brain. We examine the relationship between the structural properties of white matter streamlines (structural connectivity) and the functional properties of correlations in neural activity (functional connectivity) within 84...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 2
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    Voltage-gated potassium channel KCNV2 (Kv8.2) contributes to epilepsy susceptibility [Neuroscience] (2011)
    National Academy of Sciences
    Details
    Publication Date: 2011-03-30
    Description: Mutations in voltage-gated ion channels are responsible for several types of epilepsy. Genetic epilepsies often exhibit variable severity in individuals with the same mutation, which may be due to variation in genetic modifiers. The Scn2aQ54 transgenic mouse model has a sodium channel mutation and exhibits epilepsy with strain-dependent severity. We previously mapped modifier loci that influence Scn2aQ54 phenotype severity and identified Kcnv2, encoding the voltage-gated potassium channel subunit Kv8.2, as a candidate modifier. In this study, we demonstrate a threefold increase in hippocampal Kcnv2 expression associated with more severe epilepsy. In vivo exacerbation of the phenotype by Kcnv2 transgenes supports its identification as an epilepsy modifier. The contribution of KCNV2 to human epilepsy susceptibility is supported by identification of two nonsynonymous variants in epilepsy patients that alter function of Kv2.1/Kv8.2 heterotetrameric potassium channels. Our results demonstrate that altered potassium subunit function influences epilepsy susceptibility and implicate Kcnv2 as an epilepsy gene.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 3
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    Craton formation: Internal structure inherited from closing of the early oceans (2014)
    Geological Society of America (GSA)
    Details
    Publication Date: 2014-01-24
    Description: The closure of ancient oceans created a dynamic setting suitable for craton formation via the thickening of continental material over a mantle downwelling. This process subjected the thickening lithosphere to extensive deformation, forming internal structure that can be preserved over the lifetime of the craton. Recent seismic imaging of cratonic lithosphere has led to observations of anomalous features colloquially known as midlithospheric discontinuities. These discontinuities are attributed to a range of sources, including the lithosphere-asthenosphere boundary, melt accumulation, and phase transitions. However, the internal structure imaged within these cratons might be reflective of their formation. In particular, the orientation and nature of the variable depths of the midlithospheric discontinuities suggest a more complicated origin such as that which could be introduced during the formation and thickening phase of cratonic lithosphere. Here, we present geodynamic models demonstrating the internal structures produced during the formation of cratonic lithosphere as well as new seismological observations of midlithospheric discontinuities in the West African craton, together with reassessment of midlithospheric discontinuities observed in the North American, South African, Fennoscandia, and Australian cratons. We suggest that the midlithospheric discontinuities observed in these cratons could be remnants of deformation structures produced during the formation of the cratons after ancient oceans closed.
    Print ISSN: 1941-8264
    Electronic ISSN: 1947-4253
    Topics: Geosciences
    Published by Geological Society of America (GSA)
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  • 4
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    Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-05-07
    Description: In the adult central nervous system, the vasculature of the neurogenic niche regulates neural stem cell behavior by providing circulating and secreted factors. Age-related decline of neurogenesis and cognitive function is associated with reduced blood flow and decreased numbers of neural stem cells. Therefore, restoring the functionality of the niche should counteract some of the negative effects of aging. We show that factors found in young blood induce vascular remodeling, culminating in increased neurogenesis and improved olfactory discrimination in aging mice. Further, we show that GDF11 alone can improve the cerebral vasculature and enhance neurogenesis. The identification of factors that slow the age-dependent deterioration of the neurogenic niche in mice may constitute the basis for new methods of treating age-related neurodegenerative and neurovascular diseases.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123747/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123747/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Katsimpardi, Lida -- Litterman, Nadia K -- Schein, Pamela A -- Miller, Christine M -- Loffredo, Francesco S -- Wojtkiewicz, Gregory R -- Chen, John W -- Lee, Richard T -- Wagers, Amy J -- Rubin, Lee L -- 1DP2 OD004345/OD/NIH HHS/ -- 1R01 AG033053/AG/NIA NIH HHS/ -- 1R01 AG040019/AG/NIA NIH HHS/ -- 5U01 HL100402/HL/NHLBI NIH HHS/ -- DP2 OD004345/OD/NIH HHS/ -- R01 AG032977/AG/NIA NIH HHS/ -- R01 AG033053/AG/NIA NIH HHS/ -- R01 AG040019/AG/NIA NIH HHS/ -- R01 NS070835/NS/NINDS NIH HHS/ -- R01 NS072167/NS/NINDS NIH HHS/ -- R01NS070835/NS/NINDS NIH HHS/ -- R01NS072167/NS/NINDS NIH HHS/ -- U01 HL100402/HL/NHLBI NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2014 May 9;344(6184):630-4. doi: 10.1126/science.1251141. Epub 2014 May 5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24797482" target="_blank"〉PubMed〈/a〉
    Keywords: Aging/*drug effects ; Animals ; Bone Morphogenetic Proteins/*administration & dosage/blood/physiology ; Brain/blood supply/*drug effects ; Cerebrovascular Circulation/*drug effects ; Cognition/drug effects ; Endothelium, Vascular/cytology/drug effects ; Growth Differentiation Factors/*administration & dosage/blood/physiology ; Male ; Mice ; Mice, Inbred C57BL ; Neural Stem Cells/cytology/*drug effects ; Neurogenesis/*drug effects ; Olfactory Bulb/cytology/drug effects ; Parabiosis ; Recombinant Proteins/administration & dosage ; *Rejuvenation
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Rescue of neurodegeneration in the Fig4 null mouse by a catalytically inactive FIG4 transgene (2016)
    Oxford University Press
    Details
    Publication Date: 2016-01-09
    Description: The lipid phosphatase FIG4 is a subunit of the protein complex that regulates biosynthesis of the signaling lipid PI(3,5)P 2 . Mutations of FIG4 result in juvenile lethality and spongiform neurodegeneration in the mouse, and are responsible for the human disorders Charcot–Marie–Tooth disease, Yunis–Varon syndrome and polymicrogyria with seizures. We previously demonstrated that conditional expression of a wild-type FIG4 transgene in neurons is sufficient to rescue most of the abnormalities of Fig4 null mice, including juvenile lethality and extensive neurodegeneration. To evaluate the contribution of the phosphatase activity to the in vivo function of Fig4 , we introduced the mutation p.Cys486Ser into the Sac phosphatase active-site motif CX 5 RT. Transfection of the Fig4 Cys486Ser cDNA into cultured Fig4 –/– fibroblasts was effective in preventing vacuolization. The neuronal expression of an NSE- Fig4 Cys486Ser transgene in vivo prevented the neonatal neurodegeneration and juvenile lethality seen in Fig4 null mice. These observations demonstrate that the catalytically inactive FIG4 protein provides significant function, possibly by stabilization of the PI(3,5)P 2 biosynthetic complex and/or localization of the complex to endolysosomal vesicles. Despite this partial rescue, later in life the NSE- Fig4 Cys486Ser transgenic mice display significant abnormalities that include hydrocephalus, defective myelination and reduced lifespan. The late onset phenotype of the NSE- Fig4 Cys486Ser transgenic mice demonstrates that the phosphatase activity of FIG4 has an essential role in vivo .
    Print ISSN: 0964-6906
    Electronic ISSN: 1460-2083
    Topics: Biology , Medicine
    Published by Oxford University Press
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  • 6
    Electronic Resource
    Electronic Resource
    Selective laser photoionization for mass spectrometry (1982)
    s.l. : American Chemical Society
    Analytical chemistry 54 (1982), S. 2377-2378 
    Details
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac00250a054
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Continuous wave lasers for resonance ionization mass spectrometry (1983)
    s.l. : American Chemical Society
    Analytical chemistry 55 (1983), S. 1606-1608 
    Details
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac00260a038
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  • 8
    Electronic Resource
    Electronic Resource
    Resonance ionization mass spectrometry of uranium with intracavity laser ionization (1984)
    s.l. : American Chemical Society
    Analytical chemistry 56 (1984), S. 827-828 
    Details
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac00268a058
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  • 9
    Electronic Resource
    Electronic Resource
    Multiple photon processes in tantalum resonance ionization mass spectrometry (1985)
    s.l. : American Chemical Society
    Analytical chemistry 57 (1985), S. 1144-1147 
    Details
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac00283a033
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  • 10
    Electronic Resource
    Electronic Resource
    Pulsed laser desorption for resonance ionization mass spectrometry (1985)
    s.l. : American Chemical Society
    Analytical chemistry 57 (1985), S. 2441-2444 
    Details
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac00290a004
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