ALBERT

Description: Detailed mapping of bathymetry and three-dimensional water velocities using a boat-mounted single-beam sonar and acoustic Doppler current profiler (ADCP) was carried out in the vicinity of two submerged wing dikes located in the Lower Missouri River near Columbia, Missouri. During high spring flows the wing dikes become submerged, creating a unique combination of vertical flow separation and overtopping (plunging) flow conditions, causing large-scale three-dimensional turbulent flow structures to form. On three different days and for a range of discharges, sampling transects at 5 and 20 m spacing were completed, covering the area adjacent to and upstream and downstream from two different wing dikes. The objectives of this research are to evaluate whether an ADCP can identify and measure large-scale flow features such as recirculating flow and vortex shedding that develop in the vicinity of a submerged wing dike; and whether or not moving-boat (single-transect) data are sufficient for resolving complex three-dimensional flow fields. Results indicate that spatial averaging from multiple nearby single transects may be more representative of an inherently complex (temporally and spatially variable) three-dimensional flow field than repeated single transects. Results also indicate a correspondence between the location of calculated vortex cores (resolved from the interpolated three-dimensional flow field) and the nearby scour holes, providing new insight into the connections between vertically oriented coherent structures and local scour, with the unique perspective of flow and morphology in a large river.

Description: Subduction and exhumation of ultrahigh-pressure (UHP) metamorphic terranes are typically envisaged as short-lived processes associated with the transition from oceanic subduction to continent-continent collision. Norway’s Western Gneiss Region, by comparison, is a giant, late-orogenic UHP terrane that underwent protracted residence at UHP conditions during the Scandian phase of the Caledonian orogeny followed by relatively slow exhumation. Here, we use two-dimensional numerical thermal-mechanical models to explore the tectonics of orogens of this type and the associated controls on the size of their UHP terranes and the duration of UHP metamorphism. The models have four tectonic phases designed to capture the main stages of the Caledonian evolution: oceanic subduction and microcontinent accretion; continental margin subduction; plate quiescence; and postorogenic extension during plate divergence. Contrasting styles of exhumation are explored by varying the strength of the margin crust and investigating melt-induced weakening. The tectonic and metamorphic evolution of the Western Gneiss Region is consistent with a model in which continental margin crust was subducted beneath a thick orogenic wedge where it underwent metamorphism at (U)HP conditions for at least 15 million years (Myr) as subduction ended. The buoyant Baltican crust must have been especially strong in order to have stayed coupled to the underlying lithosphere during this phase, perhaps reflecting its refractory composition and/or a lack of fluids. Subsequent exhumation of the Western Gneiss Region can be explained by orogen-scale extension resulting from minor (~100 km) plate divergence, with removal of the orogenic wedge by combined top-to-the-hinterland transport, normal faulting, and erosion. We conclude that large, long-duration UHP terranes are fundamentally different from transient smaller ones. The latter are often explained by the paradigm of buoyant exhumation. This paradigm is incomplete, but both types can be explained by control of the system by the exhumation number (ratio of buoyancy force to basal traction). By implication, the existence of this type of large UHP terrane is a consequence of the high strength of the subducted crust.

Description: (Ultra)high-pressure [(U)HP] rocks form and exhume from deep within subduction channels, but subsequent horizontal transport in the shallower orogenic crust makes it difficult to reconstruct their tectonic histories. We use a conceptual framework and numerical models to show that buoyant exhumation from within a subduction conduit formed during one-sided subduction may lead to emplacement of (U)HP rocks into either the lower plate (prowedge) or upper plate (retrowedge) of an orogen, depending on whether the upper plate crust deforms or acts as a backstop during exhumation. Both modes may operate at different positions or different times within an orogen, leading to emplacement of (U)HP rocks into both plates without changing subduction geometry. We propose that retrotransport during exhumation may explain some (U)HP rocks (e.g., Liverpool Land) situated in the upper plate of the Greenland-Norwegian Caledonides.

Description: Cancer-associated genetic alterations induce expression of tumour antigens that can activate CD8(+) cytotoxic T cells (CTLs), but the microenvironment of established tumours promotes immune tolerance through poorly understood mechanisms. Recently developed therapeutics that overcome tolerogenic mechanisms activate tumour-directed CTLs and are effective in some human cancers. Immune mechanisms also affect treatment outcome, and certain chemotherapeutic drugs stimulate cancer-specific immune responses by inducing immunogenic cell death and other effector mechanisms. Our previous studies revealed that B cells recruited by the chemokine CXCL13 into prostate cancer tumours promote the progression of castrate-resistant prostate cancer by producing lymphotoxin, which activates an IkappaB kinase alpha (IKKalpha)-BMI1 module in prostate cancer stem cells. Because castrate-resistant prostate cancer is refractory to most therapies, we examined B cell involvement in the acquisition of chemotherapy resistance. Here we focus on oxaliplatin, an immunogenic chemotherapeutic agent that is effective in aggressive prostate cancer. We show that mouse B cells modulate the response to low-dose oxaliplatin, which promotes tumour-directed CTL activation by inducing immunogenic cell death. Three different mouse prostate cancer models were refractory to oxaliplatin unless genetically or pharmacologically depleted of B cells. The crucial immunosuppressive B cells are plasmocytes that express IgA, interleukin (IL)-10 and programmed death ligand 1 (PD-L1), the appearance of which depends on TGFbeta receptor signalling. Elimination of these cells, which also infiltrate human-therapy-resistant prostate cancer, allows CTL-dependent eradication of oxaliplatin-treated tumours.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501632/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501632/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shalapour, Shabnam -- Font-Burgada, Joan -- Di Caro, Giuseppe -- Zhong, Zhenyu -- Sanchez-Lopez, Elsa -- Dhar, Debanjan -- Willimsky, Gerald -- Ammirante, Massimo -- Strasner, Amy -- Hansel, Donna E -- Jamieson, Christina -- Kane, Christopher J -- Klatte, Tobias -- Birner, Peter -- Kenner, Lukas -- Karin, Michael -- AI043477/AI/NIAID NIH HHS/ -- CA127923/CA/NCI NIH HHS/ -- R01 AI043477/AI/NIAID NIH HHS/ -- R01 CA127923/CA/NCI NIH HHS/ -- England -- Nature. 2015 May 7;521(7550):94-8. doi: 10.1038/nature14395. Epub 2015 Apr 29.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉1] Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California San Diego (UCSD), 9500 Gilman Drive, San Diego, California 92093, USA [2] Department of Pathology, School of Medicine, University of California San Diego, 9500 Gilman Drive, San Diego, California 92093, USA. ; Institute of Immunology, Charite Campus Buch, 13125 Berlin, Germany. ; Department of Pathology, School of Medicine, University of California San Diego, 9500 Gilman Drive, San Diego, California 92093, USA. ; Department of Surgery, Urology Division, University of California San Diego, 3855 Health Sciences Drive, San Diego, California 92093, USA. ; Department of Urology, Medical University of Vienna, 1090 Vienna, Austria. ; Department of Pathology, Medical University of Vienna, 1090 Vienna, Austria. ; 1] Department of Pathology, Medical University of Vienna, 1090 Vienna, Austria [2] Clinical Institute of Pathology, Ludwig Boltzmann Institute for Cancer Research, Medical University of Vienna, Unit of Pathology of Laboratory Animals (UPLA), University of Veterinary Medicine Vienna, 1210 Vienna, Austria.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25924065" target="_blank"〉PubMed〈/a〉

Description: A new insect juvenile hormone was isolated from developing embryos of the tobacco hornworm moth, Manduca sexta. The new hormone was found with juvenile hormone I and is a 1-carbon homolog of this substance. The assigned structure is methyl (2E,6E,10-cis)-10,11-epoxy-3,7-diethyl-11-methyl-2,6-tridecadienoate, which constitutes a trishomosesquiterpenoid skeleton. This is the first chemical idetification of any juvenile hormone from insect eggs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bergot, B J -- Jamieson, G C -- Ratcliff, M A -- Schooley, D A -- New York, N.Y. -- Science. 1980 Oct 17;210(4467):336-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17796052" target="_blank"〉PubMed〈/a〉