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  • 1
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 81 (2002), S. 73-75 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: First-principles total-energy calculations suggest that interstitial hydrogen impurity forms a shallow donor in SnO2, CdO, and ZnO, but a deep donor in MgO. We generalize this result to other oxides by recognizing that there exist a "hydrogen pinning level" at about 3.0±0.4 eV below vacuum. Materials such as Ag2O, HgO, CuO, PbO, PtO, IrO2, RuO2, PbO2, TiO2, WO3, Bi2O3, Cr2O3, Fe2O3, Sb2O3, Nb2O5, Ta2O5, FeTiO3, and PbTiO3, whose conduction band minimum (CBM) lie below this level (i.e., electron affinity〉3.0±0.4 eV) will become conductive once hydrogen is incorporated into the lattice, without reducing the host. Conversely, materials such as BaO, NiO, SrO, HfO2, and Al2O3, whose CBM lie above this level (i.e., electron affinity〈3.0±0.4 eV) will remain nonconductive since hydrogen forms a deep impurity. © 2002 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 2
    Publication Date: 2010-04-03
    Description: Despite our rapidly growing knowledge about the human genome, we do not know all of the genes required for some of the most basic functions of life. To start to fill this gap we developed a high-throughput phenotypic screening platform combining potent gene silencing by RNA interference, time-lapse microscopy and computational image processing. We carried out a genome-wide phenotypic profiling of each of the approximately 21,000 human protein-coding genes by two-day live imaging of fluorescently labelled chromosomes. Phenotypes were scored quantitatively by computational image processing, which allowed us to identify hundreds of human genes involved in diverse biological functions including cell division, migration and survival. As part of the Mitocheck consortium, this study provides an in-depth analysis of cell division phenotypes and makes the entire high-content data set available as a resource to the community.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108885/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108885/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Neumann, Beate -- Walter, Thomas -- Heriche, Jean-Karim -- Bulkescher, Jutta -- Erfle, Holger -- Conrad, Christian -- Rogers, Phill -- Poser, Ina -- Held, Michael -- Liebel, Urban -- Cetin, Cihan -- Sieckmann, Frank -- Pau, Gregoire -- Kabbe, Rolf -- Wunsche, Annelie -- Satagopam, Venkata -- Schmitz, Michael H A -- Chapuis, Catherine -- Gerlich, Daniel W -- Schneider, Reinhard -- Eils, Roland -- Huber, Wolfgang -- Peters, Jan-Michael -- Hyman, Anthony A -- Durbin, Richard -- Pepperkok, Rainer -- Ellenberg, Jan -- 077192/Wellcome Trust/United Kingdom -- Wellcome Trust/United Kingdom -- England -- Nature. 2010 Apr 1;464(7289):721-7. doi: 10.1038/nature08869.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉MitoCheck Project Group, European Molecular Biology Laboratory (EMBL), Meyerhofstrasse 1, D-69117 Heidelberg, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20360735" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Division/*genetics ; Cell Movement/genetics ; Cell Survival/genetics ; Color ; Gene Knockdown Techniques ; Genes/genetics ; Genome, Human/*genetics ; HeLa Cells ; Humans ; Kinetics ; Mice ; Microscopy, Fluorescence/*methods ; Mitosis/genetics ; *Phenotype ; RNA Interference ; Reproducibility of Results ; Spindle Apparatus/genetics/metabolism ; Time Factors
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 3
    Publication Date: 2016-05-26
    Description: Noise generation mechanisms for a perfectly expanded supersonic Mach number M=1.8 turbulent jet impinging on a 45° inclined plate are investigated for a Reynolds number of 1.6 × 106 employing a large-eddy simulation. Excellent comparisons with experimental acoustic far-field measurements and pressure measurements on the impingement plate are obtained. Two local maxima are identified in the far-field overall sound pressure levels in the 75° and 120° observer directions, which are associated with different noise generation mechanisms. The peak frequencies in the spectra with Strouhal numbers of St D 0:2 for 75° and St = 0.5 for 120° match the experimental measurements. The jet-impingement region generates pressure waves that propagate predominantly in the 120° observer direction. The noise generation in this region is attributed to vortex stretching and tearing during shear-layer impingement, and shock oscillations that are induced by the motion of downstream convected vortical flow structures. The second peak in the overall sound pressure distribution at 75° is associated with noise sources located in the wall jet. The noise generation in the wall jet is associated with supersonically convecting large-scale coherent flow structures that also interact with tail shocks in the wall jet causing large localized pressure fluctuations. Strongly coherent flow structures are identified by applying proper orthogonal decomposition (POD) to the unsteady flow field. The frequency characteristics of the most energetic POD modes are distinctly different based on which energy norm is chosen. The most energetic entropy-based POD modes contain a peak frequency of approximately St = 0.4-0.6, while the most energetic turbulent kinetic-energy-based POD modes appear to be dominated by lower-frequency content. The causality method, based on Lighthill's acoustic analogy, is used to link the acoustic noise signature to the relevant physical mechanisms in the source region. A differentiation is made between the application of normalized and non-normalized cross-correlation functions for noise source identification and characterization. © Cambridge University Press 2016.
    Print ISSN: 0022-1120
    Electronic ISSN: 1469-7645
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
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  • 4
    Publication Date: 2016-08-01
    Print ISSN: 1270-9638
    Electronic ISSN: 1626-3219
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Published by Elsevier
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  • 5
    Publication Date: 2015-12-01
    Print ISSN: 0169-4332
    Electronic ISSN: 1873-5584
    Topics: Physics
    Published by Elsevier
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  • 6
    Publication Date: 2008-06-01
    Print ISSN: 0045-7930
    Electronic ISSN: 1879-0747
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Technology
    Published by Elsevier
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  • 7
    Publication Date: 2015-11-01
    Print ISSN: 0045-7930
    Electronic ISSN: 1879-0747
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Technology
    Published by Elsevier
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  • 8
    Publication Date: 2013-08-29
    Description: This paper reviews recent progress made in incompressible Navier-Stokes simulation procedures and their application to problems of engineering interest. Discussions are focused on the methods designed for complex geometry applications in three dimensions, and thus are limited to primitive variable formulation. A summary of efforts in flow solver development is given followed by numerical studies of a few example problems of current interest. Both steady and unsteady solution algorithms and their salient features are discussed. Solvers discussed here are based on a structured-grid approach using either a finite -difference or a finite-volume frame work. As a grand-challenge application of these solvers, an unsteady turbopump flow simulation procedure has been developed which utilizes high performance computing platforms. In the paper, the progress toward the complete simulation capability of the turbo-pump for a liquid rocket engine is reported. The Space Shuttle Main Engine (SSME) turbo-pump is used as a test case for evaluation of two parallel computing algorithms that have been implemented in the INS3D code. The relative motion of the grid systems for the rotorstator interaction was obtained using overact grid techniques. Unsteady computations for the SSME turbo-pump, which contains 114 zones with 34.5 million grid points, are carried out on SCSI Origin 3000 systems at NASA Ames Research Center. The same procedure has been extended to the development of NASA-DeBakey Ventricular Assist Device (VAD) that is based on an axial blood pump. Computational, and clinical analysis of this device are presented.
    Keywords: Fluid Mechanics and Thermodynamics
    Format: application/pdf
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  • 9
    Publication Date: 2018-06-06
    Description: High fidelity computations were carried out to analyze the orbiter LH2 feedline flowliner. Computations were performed on the Columbia platform which is a 10,240-processor supercluster consisting of 20 Altix nodes with 512 processor each. Various computational models were used to characterize the unsteady flow features in the turbopump, including the orbiter Low-Pressure-Fuel-Turbopump (LPFTP) inducer, the orbiter manifold and a test article used to represent the manifold. Unsteady flow originating from the orbiter LPFTP inducer is one of the major contributors to the high frequency cyclic loading that results in high cycle fatigue damage to the gimbal flowliners just upstream of the LPFTP. The flow fields for the orbiter manifold and representative test article are computed and analyzed for similarities and differences. The incompressible Navier-Stokes flow solver INS3D, based on the artificial compressibility method, was used to compute the flow of liquid hydrogen in each test article.
    Keywords: Fluid Mechanics and Thermodynamics
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  • 10
    Publication Date: 2019-08-03
    Description: Outline - Introduction: X-57 CFD task overview; Motivation. Part I, Computational simulations without propulsion: Establishing CFD (Computational Fluid Dynamics) Best Practices - Grid generation - Mesh refinement study - Numerical methods - Wind tunnel validation study; Power-Off Aerodynamic Database Results. Part II, Computational simulations with propulsion: Cruise Power-On Database; High-Lift Power-On Database. Summary.
    Keywords: Aircraft Propulsion and Power
    Type: ARC-E-DAA-TN69863 , NASA Advanced Supercomputing Advanced Modeling & Simulation (AMS) Seminar Series; Jun 13, 2019; Moffett Field, CA; United States
    Format: application/pdf
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