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  • 1
    Monograph available for loan
    Monograph available for loan
    Inside Science : a preliminary investigation of the case of global warming (1996)
    Hamburg : Max-Planck-Institut für Meteorologie
    Associated volumes
    Details Availability
    Call number: ZSP-686-195
    In: Report
    Type of Medium: Monograph available for loan
    Pages: 58 S. : graph. Darst. : 29 cm
    ISSN: 0937-1060
    Series Statement: Report / Max-Planck-Institut für Meteorologie 195
    Branch Library: GFZ Library
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  • 2
    Electronic Resource
    Electronic Resource
    SIGNALING COMPLEXES:Biophysical Constraints on Intracellular Communication (1998)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Biophysics and Biomolecular Structure 27 (1998), S. 59-75 
    Details
    ISSN: 1056-8700
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Physics
    Notes: Abstract This review surveys the kinds of protein complex that participate in cell communication and identifies, where possible, general principles by which they form and act. It also advances the notion that biophysical constraints imposed by macromolecular crowding and diffusion have had a controlling influence on the evolution of cell signaling pathways. Complexes associated with the bacterial aspartate receptor, with eucaryotic tyrosine kinase receptors, with T-cell receptors, and with focal contacts are examined together with proteins that serve as adaptors, anchors, and scaffolds for signaling complexes. The importance of diffusion in controlling the numbers and locations of signaling complexes is discussed, as is the special role played by membranes in signaling pathways.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.biophys.27.1.59
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  • 3
    Electronic Resource
    Electronic Resource
    CONFORMATIONAL SPREAD: The Propagation of Allosteric States in Large Multiprotein Complexes (2004)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Biophysics and Biomolecular Structure 33 (2004), S. 53-73 
    Details
    ISSN: 1056-8700
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Physics
    Notes: The phenomenon of allostery is conventionally described for small symmetrical oligomeric proteins such as hemoglobin. Here we review experimental evidence from a variety of systems-including bacterial chemotaxis receptors, muscle ryanodine receptors, and actin filaments-showing that conformational changes can also propagate through extended lattices of protein molecules. We explore the statistical mechanics of idealized linear and two-dimensional arrays of allosteric proteins and show that, as in the analogous Ising models, arrays of closely packed units can show large-scale integrated behavior. We also discuss proteins that undergo conformational changes driven by the hydrolysis of ATP and give examples in which these changes propagate through linear chains of molecules. We suggest that conformational spread could provide the basis of a solid-state "circuitry" in a living cell, able to integrate biochemical and biophysical events over hundreds of protein molecules.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.biophys.33.110502.132703
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  • 4
    Electronic Resource
    Electronic Resource
    Cytochalasin action (1979)
    [s.l.] : Nature Publishing Group
    Nature 282 (1979), S. 671-671 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] CERTAIN chemicals have come to stand for particular areas of biological research. Think of fluorescein isothiocyanate; 2-deoxyglucose; bis-acrylamide; a-bung-arotoxin, anti-mouse immunoglobulin. Substances such as these are hitched so firmly to a line of research that you could almost use their ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/282671a0
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  • 5
    Electronic Resource
    Electronic Resource
    Stops and starts in microtubules (1979)
    [s.l.] : Nature Publishing Group
    Nature 280 (1979), S. 537-537 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE conventional wisdom that micro-tubules run the entire length of nerve axons and dendrites probably comes from a paper by Weiss and Mayr (Acta Neuropath, supp V, 198; 1971). On page 200 these authors conclude that "each tubule is a single unitary entity, extending in uninterrupted and undivided ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/280537a0
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  • 6
    Electronic Resource
    Electronic Resource
    Membrane movements and microfilaments (1978)
    [s.l.] : Nature Publishing Group
    Nature 273 (1978), S. 265-266 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] IN recent years this subject has acquired the flavour of renaissance cosmology. There is the same abundance of speculative models and the same readiness to argue endlessly cyclicallyabout a limited number of facts. There is, in addition, something of the early astronomers in the personality of the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/273265a0
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  • 7
    Electronic Resource
    Electronic Resource
    Gel motility (1977)
    [s.l.] : Nature Publishing Group
    Nature 270 (1977), S. 560-561 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] LIKE the electron, the cell shows a different face according to how it is treated; at least, that is the conclusion to be drawn from recent papers on cell movement. Even the intuitive picture of the inside of the cell seems to depend on the techniques used. To the biochemist for example, who ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/270560a0
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  • 8
    Electronic Resource
    Electronic Resource
    Protein molecules as computational elements in living cells (1995)
    [s.l.] : Nature Publishing Group
    Nature 376 (1995), S. 307-312 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Many proteins in living cells appear to have as their primary function the transfer and processing of information, rather than the chemical transformation of metabolic intermediates or the building of cellular structures. Such proteins are functionally linked through allosteric or other ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/376307a0
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  • 9
    Electronic Resource
    Electronic Resource
    The weeds in Fibonacci's garden (1998)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 394 (1998), S. 436-437 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] ... This is an engaging, eclectic and strangely disturbing book. At one level it offers a pop-science account of biological patterns — wide-ranging, easy to read and very accessible, even for non-specialists. But beneath this, a subtext repeats insistently, page after page, like the beating ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/28781
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  • 10
    Electronic Resource
    Electronic Resource
    Reasoning for results (2001)
    [s.l.] : Nature Publishing Group
    Nature 412 (2001), S. 863-863 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] ...Let's start on safe ground. We all agree, surely, that theory — the formulation of hypotheses — is important in biology. Techniques are essential, as is the careful collection of quantitative data. But without ideas to give them shape and meaning, those endless successions of base ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/35091132
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