Publication Date:
2014-09-12
Description:
Article Subtilase SUB1, a proteolytic enzyme required for the exit of malarial parasites from host cells, represents a promising target for anti-malarial drugs. Here, Giganti et al. report the structure of Plasmodium SUB1 and identify an essential domain involved in calcium-dependent activation of the enzyme. Nature Communications doi: 10.1038/ncomms5833 Authors: David Giganti, Anthony Bouillon, Lina Tawk, Fabienne Robert, Mariano Martinez, Elodie Crublet, Patrick Weber, Christine Girard-Blanc, Stéphane Petres, Ahmed Haouz, Jean-François Hernandez, Odile Mercereau-Puijalon, Pedro M. Alzari, Jean-Christophe Barale
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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