Publication Date:
2015-10-29
Description:
Article The leukotriene receptor antagonist montelukast is an anti-asthmatic drug. Here, the authors show that montelukast reduces neuroinflammation, promotes hippocampal neurogenesis and restores learning and memory in old rats suffering from ageing-associated cognitive dysfunction. Nature Communications doi: 10.1038/ncomms9466 Authors: Julia Marschallinger, Iris Schäffner, Barbara Klein, Renate Gelfert, Francisco J. Rivera, Sebastian Illes, Lukas Grassner, Maximilian Janssen, Peter Rotheneichner, Claudia Schmuckermair, Roland Coras, Marta Boccazzi, Mansoor Chishty, Florian B. Lagler, Marija Renic, Hans-Christian Bauer, Nicolas Singewald, Ingmar Blümcke, Ulrich Bogdahn, Sebastien Couillard-Despres, D. Chichung Lie, Maria P. Abbracchio, Ludwig Aigner
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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