Publication Date:
2005-12-17
Description:
Electrical synapses are common between inhibitory neurons in the mammalian thalamus and neocortex. Synaptic modulation, which allows flexibility of communication between neurons, has been studied extensively at chemical synapses, but modulation of electrical synapses in the mammalian brain has barely been examined. We found that the activation of metabotropic glutamate receptors, via endogenous neurotransmitter or by agonist, causes long-term reduction of electrical synapse strength between the inhibitory neurons of the rat thalamic reticular nucleus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Landisman, Carole E -- Connors, Barry W -- NS050434/NS/NINDS NIH HHS/ -- NS25983/NS/NINDS NIH HHS/ -- NS40528/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2005 Dec 16;310(5755):1809-13.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neuroscience, Division of Biology and Medicine, Brown University, Providence, RI 02912, USA. Carole_Landisman@hms.harvard.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16357260" target="_blank"〉PubMed〈/a〉
Keywords:
Action Potentials
;
Animals
;
Cycloleucine/analogs & derivatives/pharmacology
;
Electric Conductivity
;
Electric Stimulation
;
Excitatory Postsynaptic Potentials
;
Gap Junctions/*physiology
;
Glycine/analogs & derivatives/pharmacology
;
In Vitro Techniques
;
Intralaminar Thalamic Nuclei/cytology/*physiology
;
Membrane Potentials
;
Neocortex/physiology
;
Neurons/*physiology
;
Neurotransmitter Agents/pharmacology
;
Patch-Clamp Techniques
;
Rats
;
Rats, Sprague-Dawley
;
Receptors, Metabotropic Glutamate/agonists/antagonists & inhibitors/*physiology
;
Synapses/physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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