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  • 1
    Electronic Resource
    Electronic Resource
    Sterols of Soil Amoebas and Ochromonas danica: Phylogenetic Approach (1966)
    Oxford, UK : Blackwell Publishing Ltd
    The @journal of eukaryotic microbiology 13 (1966), S. 0 
    Details
    ISSN: 1550-7408
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: SYNOPSIS. Sterols of Ochromonas danica, Mayorella palestinensis, Acanthamoeba sp. and Hartmannella rhysodes were examined by thin-layer and gas-liquid chromatography. The sterol patterns of O. danica and the amoebas were strikingly similar. Two of the sterols present in both groups, were identified as ergosterol and stigmasterol. This similarity is construed as evidence that “soil” amoebas evolved from phytoflagellates having sterol patterns similar to that of O. danica. An explanation is suggested for the role of ergosterol in phytoflagellates, as originally an ultra-violet-protective agent, then a membrane component.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1550-7408.1966.tb01945.x
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of Kinetin on Glucose Metabolism of Chicken Embryo Fibroblasts (1960)
    [s.l.] : Nature Publishing Group
    Nature 185 (1960), S. 388-389 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In the course of a study of the effect of various hormones on cultures of chick embryo fibroblasts3'4, it was observed that graded amounts of kinetin within the range of 12-24 pigm./ml. produced a roughly linear increase of total glucose consumption and lactic acid production (Fig. 1). The ratio ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/185388b0
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  • 3
    Electronic Resource
    Electronic Resource
    An ordered arrangement of chromosomes in the somatic nucleus of common wheat, Triticum aestivum L. (1982)
    Springer
    Chromosoma 86 (1982), S. 1-16 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Spatial relationships between chromosomes of the same genome, both homologous and non-homologous, were studied in root-tip cells of common wheat, Triticum aestivum (2n = 6x = 42). Mean distance between members of all the 21 homologous pairs (seven in each of the three genomes) and of 45 out of the 63 possible non-homologous combinations of two (21 in each genome) were determined. To minimize disruption of nuclear chromosomal arrangement, the cells were pretreated with cold temperature either in tap water or in a physiological medium (White solution) and distances between cytologically marked chromosomes were measured at metaphase. Comparison of distances for homologues with those for non-homologues indicated clearly that, within each genome, the homologous chromosomes were significantly closer to one another than were the non-homologues. Distances between homologues were similar in all three genomes, as were distances between non-homologues. The data are consistent with the hypothesis that the chromosomes of each genome of common wheat are arranged in the somatic nucleus in a highly specific ordered pattern. In this hypothetical arrangement, homologous chromosomes are closely associated, while the nonhomologues occupy definite positions with respect to one another. The universality of the phenomenon and its cellular mechanism and biological significance are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00330726
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  • 4
    Electronic Resource
    Electronic Resource
    An ordered arrangement of chromosomes in the somatic nucleus of common wheat Triticum aestivum L. (1982)
    Springer
    Chromosoma 86 (1982), S. 17-26 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Spatial relationships between chromosomes of different genomes, both homoeologues (genetically related) and non-homoeologues, were studied in root-tip cells of common wheat, Triticum aestivum L. (2n = 6x = 42) by measuring the distance between cytologically marked chromosomes in cold arrested metaphases. No significant differences were found between the means distances of the different homoeologues. Comparisons of distances between homoeologues with those between their corresponding homologues showed clearly that, in every homoeologous group, the homologous chromosomes were always closer to one another than the homoeologues. Such a pattern of homologous association and relative homoeologous separation in premeiotic cells is believed to facilitate the exclusive pairing of homologues which characterizes the meiosis of common wheat. — No significant differences were found for distances of homoeologues compared with distances of non-homoeologues of different genomes. On the other hand, mean distance between chromosomes of different genomes was significantly greater than that between non-homologues of the same genome. This difference, of course, was much greater if distances between homologues were included in the comparison. Hence, the chromosomes of different genomes are relatively separated from one another. This implies that the three wheat genomes are not intermixed but, rather, tend to occupy different areas of the somatic nucleus. The significance of these intergenomic spatial relationships, their genetic control and cellular mechanism is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00330727
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  • 5
    Electronic Resource
    Electronic Resource
    Increased spindle resistance to antimicrotubule agents in women of high risk for meiotic nondisjunction (1986)
    Springer
    Human genetics 〈Berlin〉 73 (1986), S. 199-204 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Spindle sensitivity of phytohemagglutinin (PHA)-stimulated lymphocytes to three antimicrotubule drugs was compared in two groups of women who differ in their predisposition to meiotic aneuploidy: young women of low-risk age (ranging from 22 to 34 years) and middle-aged women of high-risk age (ranging from 40 to 52 years). Numerical sensitivity values for the antimicrotubule drugs, colchicine, podophyllotoxin, and vinblastine were obtained for each woman by recording the percentage of fully arrested metaphases out of the total metaphase cell population, i.e., cells exhibiting short, thick, and condensed chromosomes with sister chromatids clearly separated at their distal parts. Sensitivity increased linearly with increasing drug concentrations and was highly correlated with youth: its rate was significantly higher for women of the low-risk group. In addition, dividing lymphocytes of young mothers (26–33 years old) of Down syndrome children revealed significantly lower sensitivity to colchicine and podophyllotoxin than those of all young women of the low-risk group and similar sensitivity to that of the middle-aged women, i.e., the high-risk age group. The data are consistent with the theory that factors involved in meiotic nondisjunction may be concurrently operating in somatic cells. These factors presumably shift the equilibrium between tubulin and microtubules towards microtubules stabilization and thereby affect some of their functions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00401227
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  • 6
    Electronic Resource
    Electronic Resource
    Arrangement of chromosomes in the interphase nucleus of plants (1980)
    Springer
    Human genetics 〈Berlin〉 55 (1980), S. 281-295 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Chromosomal arrangement in the interphase nucleus has two main aspects: (1) arrangement of chromosomes with respect to nuclear polarity and to other nuclear components, and (2) arrangement of chromosomes with respect to one another. The latter aspect consists of two main types of spatial relationships; (a) relationships between different members of one chromosomal set, (b) relationships between different chromosomal sets. Data concerning various aspects of chromosomal arrangement in the interphase nucleus are presented and discussed and the genetic control as well as subcellular mechanisms which are involvled in nuclear organization, are elucidated. Evidence is presented indicating that, in common wheat, the gene system that determines the specific pattern of chromosomal arrangement in the nucleus is operating via the microtubular elements of the spindle system. The significance of ordered arrangement of chromosomes in the nucleus for the regularity of genetic activity and chromosomal behavior, is pointed out.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00290206
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  • 7
    Electronic Resource
    Electronic Resource
    Asynchronous replication of p53 and 21q22 loci in chronic lymphocytic leukemia (1997)
    Springer
    Human genetics 〈Berlin〉 101 (1997), S. 219-222 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract In this study, in order to evaluate the replication pattern and the cell cycle dynamics of normal and malignant cells from patients with chronic lymphocytic leukemia, we applied the FISH technique with the p53 gene. Asynchrony was determined by the presence of one single and one set of double dots in the same cell. The rate of asynchronous replication was significantly higher in malignant cells than in normal cells (a mean of 28 vs 13, respectively, P = 0.023). There were proportionately more cells with two single dots among the normal cells (P = 0.0047). These results probably reflect the changes in gene replication and cell cycle progression that occur in malignant cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004390050619
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  • 8
    Electronic Resource
    Electronic Resource
    Differences between cystic fibrosis and normal cells in the degree of satellite association (1985)
    Springer
    Human genetics 〈Berlin〉 71 (1985), S. 294-300 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The degree of satellite association was found to be significantly higher in phytohemagglutinin (PHA)-stimulated lymphocytes from cystic fibrosis (CF) patients than from those of control individuals. PHA-stimulated lymphocytes from obligatory heterozygotes for the CF mutant allele showed an intermediate degree of satellite association. The degree of satellite association was estimated by the frequency of cells exhibiting associations, by the number of associations per cell, and by the number of chromosomes in an association. The differences in the degree of satellite association were dependent on the concentration of colchicine used for cell arrest. These findings may assist in developing a diagnostic method for the early identification of heterozygotes for the CF allele and for prenatal detection of CF homozygous fetuses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00388454
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  • 9
    Electronic Resource
    Electronic Resource
    Increased spindle resistance to antimicrotubule agents in cells prone to chromosomal nondisjunction (1989)
    Springer
    Human genetics 〈Berlin〉 83 (1989), S. 165-170 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The cytological behavior of the spindle apparatus was studied in cells prone to nondisjunction (ND), i.e., PHA-stimulated lymphocytes derived from children suffering from different types of neoplasia. These cells, which exhibited a high frequency of nonspecific aneuploidy, revealed an increased resistance of the spindle fibers to colchicine, podophyllotoxin, and cold, wich was several times that of lymphocytes derived from healthy children. The results are in accord with previous findings showing a high resistance of spindle microtubules to the antimicrotubular agents colchicine, podopyllotoxin, vinblastine, and cold in PHA-stimulated lymphocytes derived from individuals prone to meiotic ND. It is therefore assumed that high resistance of the spindle apparatus to antimicrotubule agents characterizes cells at high risk for aneuploidy, and possibly, the overstabilized spindle fibers are responsible for failure of chromosomal disjunction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00286711
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  • 10
    Electronic Resource
    Electronic Resource
    Somatic association of homoeologous chromosomes in Triticum aestivum (1972)
    Springer
    Chromosoma 37 (1972), S. 209-222 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The distributions of distances between members of homoeologous pairs was studied in common wheat in root-tip cells and meiocytes. In the majority of the pairs the mean distances were found to be significantly shorter than that calculated for two randomly distributed chromosomes. It could be concluded that homoeologues are loosely associated in somatic cells and more markedly so in meiocytes. However, this association is less intimate than that established previously for homologues. The tests were made in material which carries the association suppressor gene in two doses and the present findings support the assumption that in this dosage the suppressor gene has a smaller effect on homologues than on homoeologues.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00284940
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