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  • 1
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 135 (1935), S. 820-821 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] IT seems quite certain that it is not possible to explain all the effects of cosmic rays by means of a single corpuscular component. On the other hand, the results of the direct measurements of the energy of the rays, by their curvature in a magnetic field, are difficult to reconcile with the ...
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  • 2
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 133 (1934), S. 138-139 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] LES etudes de la variation du rayonnement cosmique suivant la latitude (Clay, Compton et collaborateurs, Hoerlin) ont ete effectuees jusqu'à presents avec la methode des chambres d'ionisation ; ces mesures ont montré l'existence d'un minimum de i'ionisation par rayons cosmiques dans les régions ...
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  • 3
    ISSN: 1572-8358
    Keywords: Ventricular fibrillation ; Cardiac Modelling ; Reentries ; Cellular Automata Models ; Ischemia ; Electrophysiology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The present work is aimed at investigating the effects of myocardial infarction and ischemia on induction of ventricular fibrillation. Electrophysiologic effects of global and local ischemia (variation of the dispersion of refractory periods as well as conduction velocity) on initiation of reentry mechanisms was studied by means of computer simulations based on a cellular automata model of propagation of activation wave through a ventricular surface element. A local area of ischemia where effects of the dispersion of refractory periods are investigated is then simulated. This is made using a Gaussian distribution characterized by its mean and standard deviation. These simulations show that ischemia is capable of initiating reentry phenomena which propagate through the whole ventricle; they are responsible for ventricular fibrillation which causes sudden cardiac death, even when ischemia only involves limited parts of the myocardium. Statistical study of the probability of reentries as a function of both of the size of ischemic zones and the rate of dispersion of refractory periods shows that the latter parameter is of primary importance in triggering cardiac reentries.
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Acta biotheoretica 41 (1993), S. 23-33 
    ISSN: 1572-8358
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract We study the case of two sibling species ofHippolais(Aves). Very little differences can be observed in the morphology of both species. The breeding area of these species are complementary. Roughly, one species breeds North and East of Europe (Hippolais icterina) while the other breeds South and West of Europe (Hippolais polyglotta). There exitst a narrow zone of sympatry passing through Burgundy. Since several years, it has been observed that this area of sympatry was moving in the North-East direction at a European scale. This means that progressivelyH. icterina is declining and is replaced byH. polyglotta. Some assumptions can be made in order to explain this evolution, for instance competition or predation. Series of observations concerning the diets of nestlings of both species have been realized. These observations show some differences in the diet compositions. The breeding success of the two species has been studied. Numerical simulations of a competition model taking into account the observed differences between the food types eaten by the two species are presented. These simulations do not explain the regression ofH. icterina. Then, we present numerical simulations of a predation model with one predator attacking the nestlings of both species. These simulations show that with time one of the two preys must extinct. Predation rather than competition seems to be the right explanation.
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Acta biotheoretica 43 (1995), S. 27-39 
    ISSN: 1572-8358
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The complexity and the variability of parameters occurring in ecological dynamical systems imply a large number of equations. Different methods, more or less successful, have been described to reduce this number of equations. For instance, in the paper of Auger and Roussarie (1993), the authors describe how to obtain a reduction by considering different time-scales. They consider a system which can be sub-divided into sub-systems such that the strengths of the intra-sub-systems interactions are much larger than those of the inter-sub-systems interactions. Using the Central Manifold Theorem, they obtain on the slow-manifold, a perturbation of the external dynamics by the internal dynamics. In our paper, we apply the method of Auger and Roussarie to Lotka-Volterra's classical model. Then we bring to light two interesting consequences of this method. On the one hand, this method allows to remove one of the most important objection of the Lotka-Volterra's model. The dynamics obtained on the slow-manifold are a perturbation of the external dynamics, i.e. of the well-known center, and even if the external dynamics is degenerate, the perturbation cancels this degeneration. On the other hand, we can see that a variation, even a slight variation in some cases, of individual behaviour can modify global dynamics on the slow-manifold. We obtain Hopf-bifurcations on the central manifold by varying the intra-sub-systems parameters, so that it implies that a given stable focus becomes unstable and reciprocally. We briefly exhibit how the Perturbation Theory allows to describe the dynamics on the slow-manifold.
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Acta biotheoretica 43 (1995), S. 465-476 
    ISSN: 1572-8358
    Keywords: Approximate aggregation of variables ; population dynamics ; perturbations ; time scales ; eigenvalues and eigenvectors analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Aggregation of variables allows to approximate a large scale dynamical system (the micro-system) involving many variables into a reduced system (the macro-system) described by a few number of global variables. Approximate aggregation can be performed when different time scales are involved in the dynamics of the micro-system. Perturbation methods enable to approximate the large micro-system by a macro-system going on at a slow time scale. Aggregation has been performed for systems of ordinary differential equations in which time is a continuous variable. In this contribution, we extend aggregation methods to time-discrete models of population dynamics. Time discrete micro-models with two time scales are presented. We use perturbation methods to obtain a slow macro-model. The asymptotic behaviours of the micro and macro-systems are characterized by the main eigenvalues and the associated eigenvectors. We compare the asymptotic behaviours of both systems which are shown to be similar to a certain order.
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Acta biotheoretica 41 (1993), S. 13-22 
    ISSN: 1572-8358
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract We study the influence of the individual behaviour of animals on predator-prey models. Populations of preys and predators are divided into sub-populations corresponding to different activity classes. The animals are assumed to do many activities all day long such as searching for food of different types. The preys are more vulnerable when doing some activities during which they are very exposed to predators attacks rather than for others during which they are hidden. We study activity sequences of the animals and also the effect of a change in the average individual behaviour of the animals on Lotka-Volterra prey-predator interactions. Numerical simulations are realized for the whole sets of equations (governing the subpopulations) and are compared to the simulations of the reduced sets of equation (governing the populations). We look for the validity of the method with respect to a scaling factor which measures the differences between the two time scales associated to the fast-varying variables and to the slow-time varying global variables. It is shown that when the two time scales differ of about two orders of magnitude, the approximation is satisfying.
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Acta biotheoretica 44 (1996), S. 301-316 
    ISSN: 1572-8358
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The aim of this work is to present aggregation methods of hierarchically organized systems allowing one to replace the initial micro-system by a macro-system described by a few global variables. We also study the relations between the fast micro-dynamics and the slow macro-dynamics which can produce global properties. Emergence corresponds to a bottom-up coupling that is the result effected by a micro-level at a macro-level. As an example, we present prey-predator models with different time scales in an heterogeneous environment. A fast time scale is associated to the migration process on spatial patches and a slow time scale is associated to growth and interactions between the populations. Preys must go on spatial patches where resources are located and where predators can attack them. The efficiency of the predators to catch preys is patch dependent. Perturbation methods allow us to aggregate the initial system of differential equations for the patch sub-populations into a macro-system of two differential equations governing the total population densities. We study the case of density independent and density dependent migrations. In the latter case, we show that different functional responses can emerge in the macro prey-predator model as a result of the coupling between the slow and fast systems.
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  • 9
    ISSN: 1572-8358
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract We assume the existence of a specific G1 protein which is an initiator of DNA replication. This initiator is supposed to be synthesized according to Michaelis-Menten kinetics. In order to start DNA replication, it is assumed that this G1 specific protein must be produced in a required amount. Intra-cellular growth inhibitors and extra-cellular growth factors control the production of the initiator. This model allows to calculate the average G1 phase time as a function of the various chemical concentrations of nutrients, enzymes, growth inhibitors and growth factors. This model is compared to cell kinetics experiments on a leukemic cell line responding to Interleukin 3 deprivation. The curves giving the experimental average G1 phase times with respect to Interleukin-3 concentrations are fitted by the mathematical model with a quite good agreement.
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  • 10
    ISSN: 1572-8358
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Limitations of antiarrhythmic drugs on cardiac sudden death prevention appeared since the early 80's. The "Cardiac Arrhythmia Suppression Trial"(CAST) showed more recently that mortality was significantly higher inpatients treated with some particular antiarrhythmic drugs than in non-treated patients. In this field, our group recently demonstrated that a bolus of a Class 1B antiarrhythmic drug was able to trigger a ventricular fibrillation due to transient blocks induction. The aim of the present work was to systematically study, by use of the van Capelle and Durrer (VCD) model which allows to simulate ventricular activation wave propagation, the link between arrhythmogenic effects and the ability of transient blocks to possibly degenerate in severe arrhythmias. A fragment of the ventricular wall is represented by an array of 16384elements electrically coupled. Effects of induction of one or several transient blocks, as the effects of their size and duration on possible induction of reentries have been studied. Results obtained show that various combinations between these different parameters may trigger reentries, ventricular tachycardia and/or more complex patterns assimilable to ventricular fibrillation. These results clearly evidence the fact that possible induction of transient blocks may directly be related to risk factor associated to arrhythmogenic effects of antiarrhythmic drugs.
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