ISSN:
1573-9171
Keywords:
archaebacterial C40-diol
;
(R)-5-acetoxy-4-methylpentanoic acid as a chiral building block
;
convergent synthesis
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Effective convergent syntheses of archaebacterial C40-diol [(3R,7R,11S,15S,18S,22S, 26R,30R)-octamethyldotriacontane-1,32-diol] and its (3S,7S,11R,15R,18R,22R,26S,30S)-enantiomer have been accomplished using (R)-5-acetoxy-4-methylpentanoic acid as the only chiral building block. Both synthetic schemes include consecutive construction of mono- and diterpene fragments of the target molecules followed by dimerization using the Kolbe reaction or the oxidative self-condensation of the corresponding Grignard reagent.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00702017
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